Etzer Darout
Pfizer
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Publication
Featured researches published by Etzer Darout.
Journal of Medicinal Chemistry | 2011
Kim F. McClure; Etzer Darout; Cristiano R. W. Guimarães; Michael Paul Deninno; Vincent Mascitti; Michael John Munchhof; Ralph P. Robinson; Jeffrey T. Kohrt; Anthony R. Harris; Dianna E. Moore; Bryan Li; Lacey Samp; Bruce Allen Lefker; Kentaro Futatsugi; Daniel Kung; Paul D. Bonin; Peter Cornelius; Ruduan Wang; Eben Salter; Sam Hornby; Amit S. Kalgutkar; Yue Chen
The synthesis and properties of the bridged piperidine (oxaazabicyclo) compounds 8, 9, and 11 are described. A conformational analysis of these structures is compared with the representative GPR119 ligand 1. These results and the differences in agonist pharmacology are used to formulate a conformation-based hypothesis to understand activation of the GPR119 receptor. We also show for these structures that the agonist pharmacology in rat masks the important differences in human pharmacology.
Archive | 2010
Etzer Darout; Cristiano R. W. Guimarães; Vincent Mascitti; Kim F. McClure
Archive | 2015
Etzer Darout; Kim F. McClure; David W. Piotrowski; Brian Raymer
Tetrahedron Letters | 2010
Etzer Darout; Arindrajit Basak
Tetrahedron Letters | 2011
Benjamin D. Stevens; Etzer Darout; Vincent Mascitti; Kim F. McClure
Synthesis | 2013
Stephen W. Wright; Etzer Darout; Benjamin D. Stevens
Phosphodiesterases and Their Inhibitors | 2014
Etzer Darout; Elnaz Menhaji-Klotz; Thomas A. Chappie
Archive | 2014
Etzer Darout; Robert Dullea; Julie Hawkins; Allyn T. Londregan; Paula M. Loria; Bruce Maguire; Kim F. McClure; Donna N. Petersen; David W. Piotrowski
Tetrahedron | 2012
Etzer Darout; Kim F. McClure; Vincent Mascitti
Archive | 2015
Etzer Darout; Kim F. McClure; David W. Piotrowski; Brian Kenneth Raymer
