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Francesca Mazzei

Vertex Pharmaceuticals

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Publication

Featured researches published by Francesca Mazzei.

Bioorganic & Medicinal Chemistry Letters | 2009

The discovery of the potent aurora inhibitor MK-0457 (VX-680).

David Bebbington; Hayley Binch; Jean-Damien Charrier; Simon Everitt; Damien Fraysse; Julian Golec; David Kay; Ronald Knegtel; Chau Mak; Francesca Mazzei; Andrew Miller; Michael Mortimore; Michael O’Donnell; Sanjay Patel; Francoise Pierard; Joanne Pinder; John Pollard; Sharn Ramaya; Daniel Robinson; Alistair Rutherford; John Studley; James Westcott

The identification of a novel series of Aurora kinase inhibitors and exploitation of their SAR is described. Replacement of the initial quinazoline core with a pyrimidine scaffold and modification of substituents led to a series of very potent inhibitors of cellular proliferation. MK-0457 (VX-680) has been assessed in Phase II clinical trials in patients with treatment-refractory chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) containing the T315I mutation.

Archive | 2003

Processes for preparing substituted pyrimidines

Jean-Damien Charrier; Francesca Mazzei; David Kay; Andrew Miller

Archive | 2005

Azaindoles useful as inhibitors of protein kinases

Francoise Pierard; Juan-Miguel Jimenez; Ronald Kengtel; Guy Brenchley; Michael Mortimore; Francesca Mazzei

Archive | 2003

PROCESSES FOR PREPARING SUBSTITUTED PYRIMIDINES AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE

Jean-Damien Charrier; Francesca Mazzei; David Kay; Andrew Miller

Archive | 2009

Substituted pyrimidines useful as protein kinase inhibitors

Jean-Damien Charrier; Francesca Mazzei; David Kay; Andrew Miller

Archive | 2004

Pyrazolopyrrole derivatives as protein kinase inhibitors

Hayley Binch; Simon Everitt; Francesca Mazzei; Daniel Robinson

Archive | 2014

Substituted pyrimidine as inhibitor of protein kinase and method for preparing pyrimidine derivative

Jean-Damien Charrier; チャーリアー ジーン−デミーン; Francesca Mazzei; マッゼイ フランチェスカ; David Kay; ケイ デービッド; Andrew Miller; ミラー アンドリュー

Archive | 2010

Method for preparing substituted pyrimidine as inhibitors of protein kinase and production method of pyrimidine derivative

Jean-Damien Charrier; David Kay; Francesca Mazzei; Andrew Miller; ミラー アンドリュー; チャーリアー ジーン−デミーン; ケイ デービッド; マッゼイ フランチェスカ

Archive | 2008

Azalndoles useful as inhibitors of protein kinases

Francise Pierard; Juan-Miguel Jimenez; Ronald Knegtal; Guy Brenchley; Michael Mortimore; Francesca Mazzei

Archive | 2006

Inhibitoren der histondeacetylase Inhibitors of histone deacetylase

David Festus Charles Moffat; Sanjay Ratilal Patel; Francesca Mazzei; Andrew James Belfield; Meurs Sandra Van

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Collaboration

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Andrew Miller

Vertex Pharmaceuticals

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David Kay

Vertex Pharmaceuticals

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Jean-Damien Charrier

Vertex Pharmaceuticals

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Francoise Pierard

Vertex Pharmaceuticals

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Guy Brenchley

Vertex Pharmaceuticals

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Juan-Miguel Jimenez

Vertex Pharmaceuticals

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Michael Mortimore

Loughborough University

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Daniel Robinson

Vertex Pharmaceuticals

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Hayley Binch

Vertex Pharmaceuticals

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Simon Everitt

Vertex Pharmaceuticals

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