Wolfgang Mutzel

Sterile composition comprising a chelate complex for magnetic resonance imaging

A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.

Pharmacology of Nonionic Dimers

Nonionic dimers enable us for the first time to produce highly concentrated, blood isotonic contrast media. If the toxicity of contrast media is dependent on molar quantity, molar concentration, or the motility of small molecules, nonionic dimers could have advantages over the monomeric contrast media. Their higher viscosity is a basic disadvantage. Solutions of the nonionic dimers with an iodine concentration of up to 400 mg/ml often have an osmotic pressure that is lower than that of blood. THe new contrast media are extremely hydrophilic, show no binding to protein, and lead to complement activation only in extremely high concentrations. They do not cause the deformation of the erythrocytes that is known to occur with other contrast media. The LD50 after fast intravenous injection in the rat is higher that with all other known contrast media. In peripheral arteriography, the nonionic dimers are tolerated painlessly by rats, and in carotid angiography they cause as few side effects as metrizamide. The neural tolerance is better than that of metrizamide. In circulatory investigations no drop in blood pressure was found after intravenous injection. Elimination is almost exclusively renal. As with other nonionic contrast media, properties of the dimers that appear to be problematic are formation of supersaturated solutions and nephrotoxicity after extremely high doses.

Effect of structure on biological tolerance. Comparison of triiodobenzene derivatives.

Gries H, Mützel W. Effect of structure on biological tolerance: comparison of triiodobenzene derivatives. Invest Radiol 1988;23 (Suppl 1):S97‐S100. Synthesis of basic structures of contrast media is reviewed. Biological tolerance of ionic and nonionic derivatives of triiodobenzene are related to the degree of withdrawal of electrons from their aromatic systems.

Trihalogenated benzamides — a new class of artificial sweeteners

Zusammenfassung2,4;6-Tribrom-3-carboxylalkylbenzamide und 2,4,6-Tribrom-3-carboxylalkoxybenzamide sind intensiv süß. Die 3-Carboxyethyl-Verbindung gehört mit einem Erkennungsschwellenwert von 1 gmol/l zu den süßesten bekannten Verbindungen. Die Intensität des Süßgeschmacks hängt von der Struktur des Carboxyalkyl- bzw. Carboxyalkoxyrestes ab. Die Ante Toxizität der Verbindungen für Mäuse entspricht in etwa der von Saccharin (Na-Salz) und Natriumcyclamat. Die Verbindungen sind leicht und in guter Ausbeute zugänglich.Summary2,4,6-tribromo-3-carboxyalkyl-benzamides and -carboxyalkoxy-benzamides are intensely sweet. With a recognition threshold value of about 1 gmol/1 the 3-carboxyethyl compound is one of the sweetest compounds known. The intensity of the sweet taste depends upon the nature of the carboxyalkyl/carboxylalkoxy group. In respect to the acute toxicity to mice the compounds are similar to the sodium salt of saccharin and sodium cyclamate. The compounds are easily obtainable in good yield.