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Frederic Marc Maurice Doublet

Tibotec

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Publication

Featured researches published by Frederic Marc Maurice Doublet.

Journal of Medicinal Chemistry | 2008

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121)

Jean-François Bonfanti; Christophe Meyer; Frederic Marc Maurice Doublet; Jérôme Michel Claude Fortin; Philippe Muller; Laurence Queguiner; Tom Gevers; Peggy Janssens; Heidi Szel; Rudy Edmond Willebrords; Philip Timmerman; Koen Wuyts; Pieter Van Remoortere; Frans Eduard Janssens; Piet Wigerinck; Koen Andries

A preceding paper (Bonfanti et al. J. Med Chem. 2007, 50, 4572-4584) reported the optimization of the pharmacokinetic profile of substituted benzimidazoles by reducing their tissue retention. However, the modifications that were necessary to achieve this goal also led to a significant drop in anti-RSV activity. This paper describes a molecular modeling study followed by a lead optimization program that led to the recovery of the initial potent antiviral activity and the selection of TMC353121 as a clinical candidate.

Journal of Medicinal Chemistry | 2007

Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship

Jean-François Bonfanti; Frederic Marc Maurice Doublet; Jérôme Michel Claude Fortin; Jean Fernand Armand Lacrampe; Jérôme Emile Georges Guillemont; Philippe Muller; Laurence Queguiner; Eric Arnoult; Tom Gevers; Peggy Janssens; Heidi Szel; Rudy Edmond Willebrords; Philip Timmerman; Koen Wuyts; Frans Eduard Janssens; Cois Sommen; Piet Wigerinck; Koen Andries

Archive | 2006

BENZODIAZEPINES AS HCV INHIBITORS

Jean-François Bonfanti; Frederic Marc Maurice Doublet; Origène Nyanguile; Pierre Jean-Marie Bernard Raboisson; Anne-Sophie Helene Marie Rebstock; Carlo Willy Maurice Boutton

Archive | 2004

Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication

Jean-François Bonfanti; Koenraad Jozef Lodewijk Andries; Jér{hacek over }me Michel Claude Fortin; Philippe Muller; Frederic Marc Maurice Doublet; Christophe Meyer; Rudy Edmond Willebrords; Tom Valerius Josepha Gevers; Philip Maria Martha Bern Timmerman

Archive | 2008

Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication

Jean-François Bonfanti; Koenraad Jozef Lodewijk Andries; Jérôme Michel Claude Fortin; Phillippe Muller; Frederic Marc Maurice Doublet; Christophe Meyer; Rudy Edmond Willebrords; Tom Valerius Josepha Gevers; Philip Maria Martha Bern Timmerman

Archive | 2008

10-sulfonyl-dibenzodiazepinones useful as hepatitis c virus inhibitors

Pierre Jean-Marie Bernard Raboisson; Sandrine Marie Helene Vendeville; Jean-François Bonfanti; Gowan David Craig Mc; Koen Vandyck; Frederic Marc Maurice Doublet; Lili Hu; Origène Nyanguile

Archive | 2004

5- Or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication

Jean-François Bonfanti; Koenraad Jozef Lodewijk Andries; Jérôme Michel Claude Fortin; Philippe Muller; Frederic Marc Maurice Doublet; Christophe Meyer; Rudy Edmond Willebrords; Tom Valverius Josepha Gevers; Philip Maria Martha Bern Timmerman

Archive | 2006

1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs

Jean-François Bonfanti; Philippe Muller; Jérôme Michel Claude Fortin; Frederic Marc Maurice Doublet

Archive | 2006

1- ( 2-amino-3- (substituted alkyl)-3h-benzimidazoiylmethyl) -3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus

Jean-François Bonfanti; Philippe Muller; Jérôme Michel Claude Fortin; Frederic Marc Maurice Doublet

Archive | 2017

derivados de pirimidina para o tratamento de doenças bacterianas

Frederic Marc Maurice Doublet; Jean François Bonfanti; Jérôme Michel Claude Fortin; Nacer Lounis; Philippe Muller

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Collaboration

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Jérôme Michel Claude Fortin

Janssen Pharmaceutica

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Jean-François Bonfanti

Tibotec

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Rudy Edmond Willebrords

Johnson

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Koenraad Jozef Lodewijk Marcel Andries

Janssen Pharmaceutica

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Philippe Muller

Johnson

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Christophe Meyer

Johnson

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Koenraad Jozef Lodewijk Andries

Tibotec

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Philip Maria Martha Bern Timmerman

Tibotec

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Rudy Edmond Willebrords

Johnson

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Pierre Jean-Marie Bernard Raboisson

Centre national de la recherche scientifique

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