Is this you? Create Your Porfile
Avatar

Jérôme Michel Claude Fortin

Janssen Pharmaceutica

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Jérôme Michel Claude Fortin is active.

Explore More

Publication

Featured researches published by Jérôme Michel Claude Fortin.

Journal of Medicinal Chemistry | 2008

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121)

Jean-François Bonfanti; Christophe Meyer; Frederic Marc Maurice Doublet; Jérôme Michel Claude Fortin; Philippe Muller; Laurence Queguiner; Tom Gevers; Peggy Janssens; Heidi Szel; Rudy Edmond Willebrords; Philip Timmerman; Koen Wuyts; Pieter Van Remoortere; Frans Eduard Janssens; Piet Wigerinck; Koen Andries

A preceding paper (Bonfanti et al. J. Med Chem. 2007, 50, 4572-4584) reported the optimization of the pharmacokinetic profile of substituted benzimidazoles by reducing their tissue retention. However, the modifications that were necessary to achieve this goal also led to a significant drop in anti-RSV activity. This paper describes a molecular modeling study followed by a lead optimization program that led to the recovery of the initial potent antiviral activity and the selection of TMC353121 as a clinical candidate.

Journal of Medicinal Chemistry | 2007

Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship

Jean-François Bonfanti; Frederic Marc Maurice Doublet; Jérôme Michel Claude Fortin; Jean Fernand Armand Lacrampe; Jérôme Emile Georges Guillemont; Philippe Muller; Laurence Queguiner; Eric Arnoult; Tom Gevers; Peggy Janssens; Heidi Szel; Rudy Edmond Willebrords; Philip Timmerman; Koen Wuyts; Frans Eduard Janssens; Cois Sommen; Piet Wigerinck; Koen Andries

Journal of Medicinal Chemistry | 2005

Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma.

Eddy Jean Edgard Freyne; Jean Fernand Armand Lacrampe; Frederik Deroose; Gustaaf Maria Boeckx; Marc Willems; Werner Constant Johan Embrechts; Erwin Coesemans; Johan J. Willems; Jérôme Michel Claude Fortin; Yannick Ligney; Lieve Dillen; Willy Cools; J. Goossens; David Corens; and Alex De Groot; Jean Van Wauwe

Archive | 2000

Interleukin-5 inhibiting 6-azauracil derivatives

Jean Fernand Armand Lacrampe; Eddy Jean Edgard Freyne; Frederik Deroose; Jérôme Michel Claude Fortin; Erwin Coesemans

Archive | 2002

Non-steroidal IL-5 inhibitors, processes and intermediates for their preparation and pharmaceutical compositions comprising said inhibitors

Jean Fernand Armand Lacrampe; Eddy Jean Edgard Freyne; Frederik Deroose; Jérôme Michel Claude Fortin; Erwin Coesemans

Archive | 2006

HETEROCYCLYLAMINOALKYL SUBSTITUTED BENZIMIDAZOLES

Jean-François Bonfanti; Philippe Muller; Jérôme Michel Claude Fortin; Frédéric Marc Maurice Doublet

Archive | 2015

MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS

Jean-François Bonfanti; Jérôme Michel Claude Fortin; Philippe Muller; Frédéric Marc Maurice Doublet; Pierre Jean-Marie Bernard Raboisson; Eric Arnoult

Archive | 2012

Purine derivatives for the treatment of viral infections

Jean-François Bonfanti; Frédéric Marc Maurice Doublet; Werner Constant Johan Embrechts; Jérôme Michel Claude Fortin; Gowan David Craig Mc; Philippe Muller; Pierre Jean-Marie Bernard Raboisson

Archive | 2008

6-hydroxy-dibenzodiazepinones useful as hepatitis c virus inhibitors

Pierre Jean-Marie Bernard Raboisson; Gowan David Craig Mc; Koen Vandyck; Sandrine Marie Helene Vendeville; Jean-François Bonfanti; Den Broeck Walter Marcel Mathilde Van; Origène Nyanguile; Katie Ingrid Eduard Amssoms; Lili Hu; Carlo Boutton; Abdellah Tahri; Klara Rombauts; Anne-Sophie Helene Marie Rebstock; Jérôme Michel Claude Fortin; Philippe Muller

Archive | 2006

1- ( 2-amino-3- (substituted alkyl)-3h-benzimidazoiylmethyl) -3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus

Jean-François Bonfanti; Philippe Muller; Jérôme Michel Claude Fortin; Frederic Marc Maurice Doublet

Explore More

Collaboration

Dive into the Jérôme Michel Claude Fortin's collaboration.

Top Co-Authors
Avatar

Jean-François Bonfanti

Tibotec

View shared research outputs
Top Co-Authors
Avatar

Frederic Marc Maurice Doublet

Tibotec

View shared research outputs
Top Co-Authors
Avatar

Rudy Edmond Willebrords

Johnson

View shared research outputs
Top Co-Authors
Avatar

Koenraad Jozef Lodewijk Marcel Andries

Janssen Pharmaceutica

View shared research outputs
Top Co-Authors
Avatar

Philippe Muller

Johnson

View shared research outputs
Top Co-Authors
Avatar

Frederik Deroose

Janssen Pharmaceutica

View shared research outputs
Top Co-Authors
Avatar

Frédéric Marc Maurice Doublet

Janssen Pharmaceutica

View shared research outputs
Top Co-Authors
Avatar

Eric Arnoult

Janssen Pharmaceutica

View shared research outputs
Top Co-Authors
Avatar

Pierre Jean-Marie Bernard Raboisson

Janssen Pharmaceutica

View shared research outputs
Top Co-Authors
Avatar

Werner Constant Johan Embrechts

Janssen Pharmaceutica

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge