Fupo He
Guangdong University of Technology
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Publication
Featured researches published by Fupo He.
Materials Science and Engineering: C | 2016
Fupo He; Weiwei Ren; Xiumei Tian; Wei Liu; Shanghua Wu; Xiaoming Chen
In a previous study, robust calcium carbonate composite ceramics (CC/PG) were prepared by using phosphate-based glass (PG) as an additive, which showed good cell response. In the present study the in vivo response of porous CC/PG was compared to that of porous biphasic calcium phosphate ceramics (BCP), using a rabbit femoral critical-size grafting model. The materials degradation and bone formation processes were evaluated by general observation, X-ray radiography, micro-computed tomography, and histological examination. The results demonstrated excellent biocompatibility and osteoconductivity, and progressive degradation of CC/PG and BCP. Although the in vitro degradation rate of CC/PG was distinctly faster than that of BCP, at 4week post-implantation, the bone generation and material degradation of CC/PG were less than those of BCP. Nevertheless, at postoperative week 8, the increment of bone formation and material degradation of CC/PG was pronouncedly larger than that of BCP. These results show that CC/PG is a potential resorbable bone graft aside from the traditional synthetic ones.
Biofabrication | 2017
Fupo He; Guowen Qian; Weiwei Ren; Jiyan Li; Peirong Fan; Haishan Shi; Xuetao Shi; Xin Deng; Shanghua Wu; Jiandong Ye
Polymer sphere-based scaffolds, which are prepared by bonding the adjacent spheres via sintering the randomly packed spheres, feature uniform pore structure, full three-dimensional (3D) interconnection, and considerable mechanical strength. However, bioceramic sphere-based scaffolds fabricated by this method have never been reported. Due to high melting temperature of bioceramic, only limited diffusion rate can be achieved when sintering the bioceramic spheres, which is far from enough to form robust bonding between spheres. In the present study, for the first time we fabricated 3D interconnected β-tricalcium phosphate ceramic sphere-based (PG/TCP) scaffolds by introducing phosphate-based glass (PG) as sintering additive and placing uniaxial pressure during the sintering process. The sintering mechanism of PG/TCP scaffolds was unveiled. The PG/TCP scaffolds had hierarchical pore structure, which was composed by interconnected macropores (>200 μm) among spheres, pores (20–120 μm) in the interior of spheres, and micropores (1–3 μm) among the grains. During the sintering process, partial PG reacted with β-TCP, forming β-Ca2P2O7; metal ions from PG substituted to Ca2+ sites of β-TCP. The mechanical properties (compressive strength 2.8–10.6 MPa; compressive modulus 190–620 MPa) and porosity (30%–50%) of scaffolds could be tailored by manipulating the sintering temperatures. The introduction of PG accelerated in vitro degradation of scaffolds, and the PG/TCP scaffolds showed good cytocompatibility. This work may offer a new strategy to prepare bioceramic scaffolds with satisfactory physicochemical properties for application in bone regeneration.
Colloids and Surfaces B: Biointerfaces | 2018
Ye Tian; Teliang Lu; Fupo He; Yubin Xu; Haishan Shi; Xuetao Shi; Fei Zuo; Shanghua Wu; Jiandong Ye
β-tricalcium phosphate (β-TCP) is well known as a resorbable bone repair material due to its inherent excellent biocompatibility and osteoconductivity. However, β-TCP is encountered with osteostimulation-deficiency and poor mechanical strength because of poor sinterability. Herein, we prepared novel β-TCP composite ceramics (TCP/SPGs) by introducing strontium-containing phosphate-based glass (SPG; 45P2O5-32SrO-23Na2O) as sintering additive. The SPG helped to achieve efficient liquid-phase sintering of β-TCP at 1100 °C. The compressive strength of TCP/SPGs with 15 wt.% SPG (TCP/SPG15) was 2.65 times as high as that of plain β-TCP ceramic. The SPG reacted with β-TCP, and the Sr2+ and Na2+ from SPG replaced Ca2+ in the lattice structure of β-TCP, enabling the sustained release of strontium from TCP/SPGs. In vitro cytological test indicated that TCP/SPGs with certain amount of SPG were highly biocompatible, and noticeably promoted osteogenesis, and inhibited osteoclastic activities. Our results suggested that the TCP/SPG15 might be potential high-strength bone grafts used for bone defect repair, especially in the osteoporotic condition.
Materials Science and Engineering: C | 2018
Shenglei Feng; Fupo He; Jiandong Ye
In this study, hierarchically porous calcium phosphate scaffolds (HTCP) with unidirectional pores, transversely interconnected pores, and micropores were fabricated by the combination of extrusion and porogen burnout technique. Gelatin was incorporated into the HTCP scaffolds by vacuum-impregnation of gelatin solution and subsequent freeze-drying. The phase composition, microstructure, physical and cytobiological properties were analyzed. The results showed that the HTCP scaffolds were composed of β-tricalcium phosphate with minor hydroxyapatite. The HTCP scaffolds had unidirectional pores (~400μm), transversely interconnected pores (~130μm) and micropores (~1μm). The incorporation of gelatin significantly increased the compressive strength, toughness, and cell seeding of the HTCP scaffolds. The composite scaffolds showed excellent cytocompatibility. The hierarchically porous calcium phosphate composite scaffolds may have potential application prospects in bone tissue engineering.
Journal of The Mechanical Behavior of Biomedical Materials | 2018
Fupo He; Teliang Lu; Ye Tian; Xue Li; Fei Zuo; Xuetao Shi; Jiandong Ye
β-tricalcium phosphate (β-TCP) bioceramic, which is a prevalent bone graft, is deficient in mechanical strength and mediating the biological functions. In the present study, β-tricalcium phosphate composite bioceramics (TCP/SPNs) were prepared by introducing SrO-P2O5-Na2O based (SPN) sintering additive. With increasing mole ratio of SrO to P2O5, the SPN tended to crystallize. In the liquid-phase sintering process, β-TCP reacted with SPN, producing new compounds. The difference in characteristic of SPN additive affected the compressive strength and cell-biological response of the fabricated TCP/SPNs. By selecting SPN with appropriate formulation, the TCP/SPNs not only could more than double their compressive strength, but also improved the cell viability, promoted osteogenic differentiation and inhibited osteoclastic activities. Taken together, this work establishes a beneficial strategy to improve the overall performance of calcium phosphate bioceramic for application in bone regeneration.
ACS Applied Materials & Interfaces | 2017
Jinhuan Ke; Fupo He; Jiandong Ye
Yttria-stabilized tetragonal zirconia (Y-TZP) has been proposed as a potential dental implant because of its good biocompatibility, excellent mechanical properties, and distinctive aesthetic effect. However, Y-TZP cannot form chemical bonds with bone tissue because of its biological inertness, which affects the reliability and long-term efficacy of Y-TZP implants. In this study, to improve the bioactivity of Y-TZP ceramics while maintaining their good mechanical performance, Y-TZP was modified by grain-boundary activation via the infiltration of a bioactive glass (BG) sol into the surface layers of Y-TZP ceramics under different negative pressures (atmospheric pressure, -0.05 kPa, and -0.1 kPa), followed by gelling and sintering. The in vitro bioactivity, mechanical properties, and cell behavior of the Y-TZP with improved bioactivity were systematically investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive spectrometry (EDS), electron probe microanalysis (EPMA), and Raman spectroscopy. The results of the bioactivity test conducted by immersing Y-TZP in simulated body fluid (SBF) showed that a bonelike apatite layer was produced on the entire surface. The mechanical properties of the modified Y-TZP decreased as the negative pressure in the BG-infiltration process increased relative to those of the Y-TZP blank group. However, the samples infiltrated with the BG sol under -0.05 kPa and atmospheric pressure still retained good mechanical performance. The cell-culture results revealed that the bioactive surface modification of Y-TZP could promote cell adhesion and differentiation. The present work demonstrates that the bioactivity of Y-TZP can be enhanced by grain-boundary activation, and the bioactive Y-TZP is expected to be a potential candidate for use as a dental implant material.
Ceramics International | 2016
Maopeng Zhou; Wei Liu; Haidong Wu; Xuan Song; Yong Chen; Lixia Cheng; Fupo He; Shixi Chen; Shanghua Wu
Ceramics International | 2016
Jingqun Liu; Jiyan Li; Jiandong Ye; Fupo He
Ceramics International | 2016
Fupo He; Yanqiu Yang; Jiandong Ye
Ceramics International | 2017
Shenglei Feng; Fupo He; Jiandong Ye