Garry Procter

Epoxy-silanes in organic synthesis

Abstract Stereoselective reactions involving functionalised β,γ epoxysilanes and epoxide-allylsilanes provide a range of synthetically useful transformations.

Allylsilanes in organic synthesis; convenient preparation of synthetic intermediates by catalytic hydrosilation of acetylenic alcohols

Abstract Synthetically useful vinylslane-alcohols such as (1) can be easily prepared by the catalytic hydrosilation of the appropriate acetylenic alcohols in high yield, and with excellent regioand stereoselectivity, without the need to protect the hydroxyl group.

Stereoselective additions to α,β-epoxy-aldehydes; the formation of “non-chelation controlled” products

Abstract The addition of methyl lithium, methyl magnesium halides, and allylstannanes to the α,β-epoxy-aldehydes (4) and (5) takes place with moderate to high stereoselectivity to give products which correspond to “non-chelation controlled” addition to the aldehyde group.

Stereoselective cycloadditions of chiral acyl-nitroso compounds; synthetically useful reactions of the adducts

Abstract The adducts from the addition of acyl-nitroso compounds to dienes are shown to undergo reactions which are important for their use in synthesis, via cleavage of the NO bond to produce monocyclic systems followed by further functionalisation.

Allylsilanes in organic synthesis; Stereoselective hydroxylactonisation of chiral amide-allylsilanes

Abstract The amide-allylsilanes (1) and (10) undergo stereoselective hydroxylactonisation on treatment with m-CPBA, the major products from (1) and (10) were converted into parasorbic acid (9) and the carpenter bee pheromone (13) respectively.

A Total Synthesis of the Natural Enantiomer of the Gastroprotective Natural Products AI-77-B and Amicoumacin C Hydrochloride

Abstract A total synthesis of the natural enantiomer of AI-77-B and amicoumacin C hydrochloride is described.

On the origin of the diastereoselectivity observed in cycloadditions of chiral acyl-nitroso compounds

Abstract Molecular mechanics calculations support the models advanced to account forthe diastereoselectivity observed in cycloadditions to chiral acyl-nitroso compounds.

Allylsilanes in organic synthesis; An approach to the stereoselective synthesis of units for natural product synthesis

Abstract Allylsilane chemistry been used in the stereoselective syntheses of (13), a system which could serve in the synthesis of several polyketide natural products including tiransamycin.

Studies on the synthesis of solenolide f.; a cr(ii)-mediated cyclization to form the ten-membered ring

Abstract The fused 6–10 bicyclic framework common to the briarein diterpenoids has been constructed using a Cr(II)-mediated cyclization of an aldehyde-vinyl iodide precursor

Allylsilanes in organic synthesis; stereoselective synthesis of trans-alkene peptide isosteres

Abstract Lactones obtained by the diastereoselective dihydroxylation of ester-allylsilanes have been used in the stereocontrolled synthesis of trans-alkene dipeptide isosteres.