George F. Huhn

A Large Scale Preparation of the Cognitive Enhancer Linopirdine

Abstract Linopirdine is a pharmacologically potent drug which stimulates central nervous system neurotransmitter release. A facile process used to synthesize linopirdine on a commercial manufacturing scale consisting of seven chemical steps with only a single isolated intermediate is described.

A Practical Preparation of 7-Methoxy-3(2H)-Benzofuranone

Abstract A practical new synthesis suitable for large-scale production of 7-methoxy-3(2H)-benzofuranone by conversion of commercially available 2-hydroxy-3-methoxybenzoic acid to 7-methoxy-3-acetoxybenzofuran followed by hydrolysis is described.

Purification of Nucleoside-5′-diphosphates: A New Ion-Exchange Method

Abstract Inosine- and uridine-5′-diphosphates can be purified by ion-exchange chromatography utilizing a new ion-exchange method where Type 1 ion-exchange resins and the absorbed nucleoside polyphosphates are changed to the basic form by rinsing the column with dilute sodium hydroxide and subsequently eluting with dilute hydrochloric acid and sodium chloride.