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Dive into the research topics where Gerald A. Eddy is active.

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Featured researches published by Gerald A. Eddy.


Virology | 1980

Biochemical characterization of Rift Valley fever virus.

Robert M. Rice; Barry J. Erlick; Robert R. Rosato; Gerald A. Eddy; Sashi B. Mohanty

Abstract Rift Valley fever virus (RVFV) polypeptides were shown to share similar biochemical properties with members of the family Bunyaviradae. Electrophoretic analysis of RVFV revealed one nonglycosylated and two glycosylated major proteins with molecular weights of 25,000, 56,000, and 65,000, respectively. In addition, a 100,000 MW glycoprotein was found. The 25,000 MW protein was identified as the major nucleocapsid protein. The virion density in CsCl was 1.21 g/ml, while that of the nucleocapsid was 1.29 g/ml. The number and molecular weights of major structural polypeptides of several diverse RVFV isolates were identical. The presence of three RNA segments, large, medium, and small, with molecular weights of 2.7, 1.7, and 0.6 × 10 6 , was demonstrated. The close relationships of RVFV proteins and RNA with reported molecular weights of some members of the Phlebotomus fever (PHL) group viruses were compatible with the serological cross-reactivity among these viruses. These findings support the classification of RVFV with the PHL group viruses in the family Bunyaviradae.


Virology | 1974

Comparative electrophoretic studies on the structural proteins of selected group a arboviruses

Carl E. Pedersen; Stephen C Marker; Gerald A. Eddy

Abstract Comparative discontinuous, disc gel electrophoresis of various strains of six group A arboviruses revealed no apparent differences between the smallest (core) proteins (VP 3) of the strains examined. Observations of the larger (envelope) proteins (VP 1 and VP 2) suggested strain to strain and virus to virus differences in the molecular weights of the virion envelope components.


Advances in Experimental Medicine and Biology | 1993

Changes in follicular dendritic cell and CD8+ cell function in macaque lymph nodes following infection with SIV251.

Yvonne J. Rosenberg; Marie H. Kosco; Mark G. Lewis; Enrique C. Leon; Jack Greenhouse; Kyle E. Bieg; Gerald A. Eddy; Philip M. Zack

By virtue of their extensive meshlike network of dendritic processes expressing C3b, C3d and Fc receptors, follicular dendritic cells (FDC) found in lymphoid follicles are able to trap and retain unprocessed antigen in the form of Ag/Ab complexes (1-4). As such these cells provide the microenvironment for germinal centre reactions in which antigen specific B cells proliferate, differentiate into memory cells and antibody forming cell precursors and undergo class switching and affinity maturation. To date FDCs appear to serve two major functions. Firstly to present immunogen in the form of iccosomes to B cells and secondly as a source of of a costimulatory signal(s) required for B cell proliferation (Tew et. al. and Burton et.al., this volume). Although T cells are also required for germinal centre formation in vivo and for cluster formation and proliferation in vitro, little is known about FDC/T cells interactions. An understanding of these roles is achieved by dissecting the cellular and molecular interactions leading to the spontaneous cluster formation and proliferation observed in in vitro cultures of FDC-enriched lymphoid cells 5,6).


AIDS Research and Human Retroviruses | 1994

Genetic Analysis of HIV-1 Isolates from Brazil Reveals Presence of Two Distinct Genetic Subtypes

Joost Louwagie; Eric Delwart; James I. Mullins; Francine McCutchan; Gerald A. Eddy; Donald S. Burke


Proceedings of the National Academy of Sciences of the United States of America | 1991

Protection of macaques with a simian immunodeficiency virus envelope peptide vaccine based on conserved human immunodeficiency virus type 1 sequences.

Avigdor Shafferman; Peter B. Jahrling; Raoul E. Benveniste; Mark G. Lewis; Terri J. Phipps; Francine Eden-McCutchan; Jerold Sadoff; Gerald A. Eddy; Donald S. Burke


AIDS Research and Human Retroviruses | 1993

Decline in the CD4+ Lymphocyte Population in the Blood of SIV-Infected Macaques Is Not Reflected in Lymph Nodes

Yvonne J. Rosenberg; Philip M. Zack; Brian D. White; Sue F. Papermaster; William R. Elkins; Gerald A. Eddy; Mark G. Lewis


Journal of Virology | 1999

Limited Protection from a Pathogenic Chimeric Simian-Human Immunodeficiency Virus Challenge following Immunization with Attenuated Simian Immunodeficiency Virus

Mark G. Lewis; Jake Yalley-Ogunro; Jack Greenhouse; Terry Brennan; Jennifer Bo Jiang; Thomas C. VanCott; Yichen Lu; Gerald A. Eddy; Deborah L. Birx


AIDS Research and Human Retroviruses | 1994

Immunological and Virological Changes Associated with Decline in CD4/CD8 Ratios in Lymphoid Organs of SIV-Infected Macaques

Yvonne J. Rosenberg; Philip M. Zack; Enrique C. Leon; B.D. White; S.F. Papermaster; E. Hall; Jack Greenhouse; Gerald A. Eddy; Mark G. Lewis


The Journal of Infectious Diseases | 1979

Evaluation in Humans of a New, Inactivated Vaccine for Venezuelan Equine Encephalitis Virus (C-84)

Robert Edelman; Michael S. Ascher; Charles N. Oster; Helen H. Ramsburg; Francis E. Cole; Gerald A. Eddy


American Journal of Tropical Medicine and Hygiene | 1978

Pathology of Bolivian Hemorrhagic Fever in the African Green Monkey

Charles G. McLeod; James L. Stookey; John D White; Gerald A. Eddy; George A Fry

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Mark G. Lewis

Southern Research Institute

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Peter B. Jahrling

National Institutes of Health

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Philip M. Zack

Walter Reed Army Institute of Research

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Francine E. McCutchan

Henry M. Jackson Foundation for the Advancement of Military Medicine

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Joost Louwagie

Henry M. Jackson Foundation for the Advancement of Military Medicine

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Raoul E. Benveniste

University of Wisconsin-Madison

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Avigdor Shafferman

Israel Institute for Biological Research

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Aurelio Cafaro

Henry M. Jackson Foundation for the Advancement of Military Medicine

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Beth Ungar

Henry M. Jackson Foundation for the Advancement of Military Medicine

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