Gerald A. Eddy
United States Department of the Army
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Featured researches published by Gerald A. Eddy.
Virology | 1980
Robert M. Rice; Barry J. Erlick; Robert R. Rosato; Gerald A. Eddy; Sashi B. Mohanty
Abstract Rift Valley fever virus (RVFV) polypeptides were shown to share similar biochemical properties with members of the family Bunyaviradae. Electrophoretic analysis of RVFV revealed one nonglycosylated and two glycosylated major proteins with molecular weights of 25,000, 56,000, and 65,000, respectively. In addition, a 100,000 MW glycoprotein was found. The 25,000 MW protein was identified as the major nucleocapsid protein. The virion density in CsCl was 1.21 g/ml, while that of the nucleocapsid was 1.29 g/ml. The number and molecular weights of major structural polypeptides of several diverse RVFV isolates were identical. The presence of three RNA segments, large, medium, and small, with molecular weights of 2.7, 1.7, and 0.6 × 10 6 , was demonstrated. The close relationships of RVFV proteins and RNA with reported molecular weights of some members of the Phlebotomus fever (PHL) group viruses were compatible with the serological cross-reactivity among these viruses. These findings support the classification of RVFV with the PHL group viruses in the family Bunyaviradae.
Virology | 1974
Carl E. Pedersen; Stephen C Marker; Gerald A. Eddy
Abstract Comparative discontinuous, disc gel electrophoresis of various strains of six group A arboviruses revealed no apparent differences between the smallest (core) proteins (VP 3) of the strains examined. Observations of the larger (envelope) proteins (VP 1 and VP 2) suggested strain to strain and virus to virus differences in the molecular weights of the virion envelope components.
Advances in Experimental Medicine and Biology | 1993
Yvonne J. Rosenberg; Marie H. Kosco; Mark G. Lewis; Enrique C. Leon; Jack Greenhouse; Kyle E. Bieg; Gerald A. Eddy; Philip M. Zack
By virtue of their extensive meshlike network of dendritic processes expressing C3b, C3d and Fc receptors, follicular dendritic cells (FDC) found in lymphoid follicles are able to trap and retain unprocessed antigen in the form of Ag/Ab complexes (1-4). As such these cells provide the microenvironment for germinal centre reactions in which antigen specific B cells proliferate, differentiate into memory cells and antibody forming cell precursors and undergo class switching and affinity maturation. To date FDCs appear to serve two major functions. Firstly to present immunogen in the form of iccosomes to B cells and secondly as a source of of a costimulatory signal(s) required for B cell proliferation (Tew et. al. and Burton et.al., this volume). Although T cells are also required for germinal centre formation in vivo and for cluster formation and proliferation in vitro, little is known about FDC/T cells interactions. An understanding of these roles is achieved by dissecting the cellular and molecular interactions leading to the spontaneous cluster formation and proliferation observed in in vitro cultures of FDC-enriched lymphoid cells 5,6).
AIDS Research and Human Retroviruses | 1994
Joost Louwagie; Eric Delwart; James I. Mullins; Francine McCutchan; Gerald A. Eddy; Donald S. Burke
Proceedings of the National Academy of Sciences of the United States of America | 1991
Avigdor Shafferman; Peter B. Jahrling; Raoul E. Benveniste; Mark G. Lewis; Terri J. Phipps; Francine Eden-McCutchan; Jerold Sadoff; Gerald A. Eddy; Donald S. Burke
AIDS Research and Human Retroviruses | 1993
Yvonne J. Rosenberg; Philip M. Zack; Brian D. White; Sue F. Papermaster; William R. Elkins; Gerald A. Eddy; Mark G. Lewis
Journal of Virology | 1999
Mark G. Lewis; Jake Yalley-Ogunro; Jack Greenhouse; Terry Brennan; Jennifer Bo Jiang; Thomas C. VanCott; Yichen Lu; Gerald A. Eddy; Deborah L. Birx
AIDS Research and Human Retroviruses | 1994
Yvonne J. Rosenberg; Philip M. Zack; Enrique C. Leon; B.D. White; S.F. Papermaster; E. Hall; Jack Greenhouse; Gerald A. Eddy; Mark G. Lewis
The Journal of Infectious Diseases | 1979
Robert Edelman; Michael S. Ascher; Charles N. Oster; Helen H. Ramsburg; Francis E. Cole; Gerald A. Eddy
American Journal of Tropical Medicine and Hygiene | 1978
Charles G. McLeod; James L. Stookey; John D White; Gerald A. Eddy; George A Fry
Collaboration
Dive into the Gerald A. Eddy's collaboration.
Henry M. Jackson Foundation for the Advancement of Military Medicine
View shared research outputsHenry M. Jackson Foundation for the Advancement of Military Medicine
View shared research outputsHenry M. Jackson Foundation for the Advancement of Military Medicine
View shared research outputsHenry M. Jackson Foundation for the Advancement of Military Medicine
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