Gita P. Shah | Researchain

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Featured researches published by Gita P. Shah.

Bioorganic & Medicinal Chemistry Letters | 1993

Synthesis and pharmacological properties of BW315c and other inotropic 2-arylimidazo[1,2-a]pyrazines

Paul Barraclough; James W. Black; David Cambridge; V. Paul Gerskowitch; Heather Giles; Robert C. Glen; Robert A. D. Hull; W. Richard King; Malcolm Stuart Nobbs; Peter Randall; Gita P. Shah; David Stone; Susan J. Vine; Mark V. Whiting

A series of 2-aryl imidazo[1,2-a]pyrazines has been prepared and evaluated for inotropic activity. Sulphoxide 12, BW315C, displayed potent inotropic effects having comparable in vitro and vivo inotropic potencies to those of isomazole. Structure-activity relationships are discussed.

Journal of Medicinal Chemistry | 2007

Factor Xa Inhibitors: S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-Morpholin-4-Yl-2-Oxoethyl]-2-Oxopyrrolidin-3-Yl}Sulfonamides.

Chuen Chan; Alan David Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Matthew Campbell; Laiq Chaudry; Chun-wa Chung; J. Nicole Hamblin; Lisa Johnstone; Henry A. Kelly; Savvas Kleanthous; Angela Patikis; Champa Patel; Anthony J. Pateman; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Helen E. Weston; Caroline Whitworth; and Robert J. Young; Ping Zhou

Bioorganic & Medicinal Chemistry Letters | 2006

Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs

Robert J. Young; Matthew Campbell; Alan D. Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Chuen Chan; Miriam C. Crowe; Satish Dayal; Hawa Diallo; Henry A. Kelly; N. Paul King; Savvas Kleanthous; Andrew M. Mason; Jackie E. Mordaunt; Champa Patel; Anthony J. Pateman; Stefan Senger; Gita P. Shah; Paul W. Smith; Nigel S. Watson; Helen E. Weston; Ping Zhou

Bioorganic & Medicinal Chemistry Letters | 2007

Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa.

Robert J. Young; David W. Brown; Cynthia L. Burns-Kurtis; Chuen Chan; Julia A. Hubbard; Henry A. Kelly; Anthony J. Pateman; Angela Patikis; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Ping Zhou

Bioorganic & Medicinal Chemistry Letters | 2006

Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.

Nigel S. Watson; David W. Brown; Matthew Campbell; Chuen Chan; Laiq Chaudry; Rebecca Fenwick; J. Nicole Hamblin; Claudine Haslam; Henry A. Kelly; N. Paul King; Cynthia L. Kurtis; Andrew R. Leach; Gary R. Manchee; Andrew M. Mason; Charlotte Jane Mitchell; Champa Patel; Vipulkumar Kantibhai Patel; Stefan Senger; Gita P. Shah; Helen E. Weston; Caroline Whitworth; Robert J. Young

Bioorganic & Medicinal Chemistry Letters | 2008

Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs.

Robert J. Young; Alan D. Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Matthew Campbell; Chuen Chan; Marie Charbaut; Chun-wa Chung; Henry A. Kelly; N. Paul King; Savvas Kleanthous; Andrew M. Mason; Anthony J. Pateman; Angela Patikis; Ivan Leo Pinto; Derek Pollard; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Helen E. Weston

Bioorganic & Medicinal Chemistry Letters | 2008

Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.

Robert J. Young; Alan D. Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Matthew Campbell; Chuen Chan; Marie Charbaut; Hawa Diallo; Eric Hortense; Wendy R. Irving; Henry A. Kelly; N. Paul King; Savvas Kleanthous; Andrew M. Mason; Anthony J. Pateman; Angela Patikis; Ivan Leo Pinto; Derek Pollard; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Helen E. Weston; Ping Zhou

Bioorganic & Medicinal Chemistry Letters | 2007

Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.

Stefan Senger; Chuen Chan; Julia A. Hubbard; Gita P. Shah; Nigel S. Watson; Robert J. Young

Archive | 2002

Pyrrolidin-2-one derivatives as inhibitors of factor xa

Chuen Glaxosmithkline Chan; Julie Nicole Hamblin; Henry A. Kelly; Nigel Paul King; Andrew McMurtrie GlaxoSmithKline Mason; Vipulkumar Kantibhai Patel; Stefan Senger; Gita P. Shah; Nigel S. Watson; Helen E. Weston; Caroline Whitworth; Robert J. Young

Archive | 2002