Helen E. Weston | Researchain

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Featured researches published by Helen E. Weston.

Journal of Medicinal Chemistry | 1998

Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides

Paul W Smith; Steven Leslie Sollis; Peter D. Howes; Peter C. Cherry; Ian D. Starkey; Kevin N. Cobley; Helen E. Weston; Jan Scicinski; Andrew Thomas Merritt; Andrew R. Whittington; Paul G. Wyatt; Neil Taylor; Darren V. S. Green; Richard C. Bethell; Safia Madar; Robert J. Fenton; Peter J. Morley; Tony Pateman; Alan Beresford

Journal of Medicinal Chemistry | 2000

Selective plasma hydrolysis of glucocorticoid γ-lactones and cyclic carbonates by the enzyme paraoxonase : An ideal plasma inactivation mechanism

Keith Biggadike; Richard Martyn Angell; Colin M. Burgess; Rosanne M. Farrell; Ashley Paul Hancock; Andy J. Harker; Wendy R. Irving; Chris Ioannou; Panayiotis A. Procopiou; Rupert E. Shaw; Yemisi E. Solanke; Onkar M. P. Singh; Michael A. Snowden; Rob J. Stubbs; Sarah Walton; Helen E. Weston

Journal of Medicinal Chemistry | 2007

Factor Xa Inhibitors: S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-Morpholin-4-Yl-2-Oxoethyl]-2-Oxopyrrolidin-3-Yl}Sulfonamides.

Chuen Chan; Alan David Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Matthew Campbell; Laiq Chaudry; Chun-wa Chung; J. Nicole Hamblin; Lisa Johnstone; Henry A. Kelly; Savvas Kleanthous; Angela Patikis; Champa Patel; Anthony J. Pateman; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Helen E. Weston; Caroline Whitworth; and Robert J. Young; Ping Zhou

Bioorganic & Medicinal Chemistry Letters | 2006

Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs

Robert J. Young; Matthew Campbell; Alan D. Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Chuen Chan; Miriam C. Crowe; Satish Dayal; Hawa Diallo; Henry A. Kelly; N. Paul King; Savvas Kleanthous; Andrew M. Mason; Jackie E. Mordaunt; Champa Patel; Anthony J. Pateman; Stefan Senger; Gita P. Shah; Paul W. Smith; Nigel S. Watson; Helen E. Weston; Ping Zhou

Bioorganic & Medicinal Chemistry Letters | 2006

Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.

Nigel S. Watson; David W. Brown; Matthew Campbell; Chuen Chan; Laiq Chaudry; Rebecca Fenwick; J. Nicole Hamblin; Claudine Haslam; Henry A. Kelly; N. Paul King; Cynthia L. Kurtis; Andrew R. Leach; Gary R. Manchee; Andrew M. Mason; Charlotte Jane Mitchell; Champa Patel; Vipulkumar Kantibhai Patel; Stefan Senger; Gita P. Shah; Helen E. Weston; Caroline Whitworth; Robert J. Young

Bioorganic & Medicinal Chemistry Letters | 2008

Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs.

Robert J. Young; Alan D. Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Matthew Campbell; Chuen Chan; Marie Charbaut; Chun-wa Chung; Henry A. Kelly; N. Paul King; Savvas Kleanthous; Andrew M. Mason; Anthony J. Pateman; Angela Patikis; Ivan Leo Pinto; Derek Pollard; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Helen E. Weston

Bioorganic & Medicinal Chemistry Letters | 2008

Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.

Robert J. Young; Alan D. Borthwick; David W. Brown; Cynthia L. Burns-Kurtis; Matthew Campbell; Chuen Chan; Marie Charbaut; Hawa Diallo; Eric Hortense; Wendy R. Irving; Henry A. Kelly; N. Paul King; Savvas Kleanthous; Andrew M. Mason; Anthony J. Pateman; Angela Patikis; Ivan Leo Pinto; Derek Pollard; Stefan Senger; Gita P. Shah; John R. Toomey; Nigel S. Watson; Helen E. Weston; Ping Zhou

Archive | 2002

Pyrrolidin-2-one derivatives as inhibitors of factor xa

Chuen Glaxosmithkline Chan; Julie Nicole Hamblin; Henry A. Kelly; Nigel Paul King; Andrew McMurtrie GlaxoSmithKline Mason; Vipulkumar Kantibhai Patel; Stefan Senger; Gita P. Shah; Nigel S. Watson; Helen E. Weston; Caroline Whitworth; Robert J. Young

Archive | 2002

Pyrrolidine derivatives as factor Xa inhibitors

Archive | 2008

Sulfonamide derivatives, the preparation process thereof, and pharmaceutical compositions containing the same

Chuen Chan; Julie Nicole Hamblin; Henry A. Kelly; Nigel Paul King; Andrew Mcmurtrie Mason; Vipulkumar Kantibhai Patel; Stefan Senger; Gita P. Shah; Nigel S. Watson; Helen E. Weston; Caroline Whitworth; Robert J. Young

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