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Godwin Kumi

Lexicon Pharmaceuticals

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Publication

Featured researches published by Godwin Kumi.

Bioorganic & Medicinal Chemistry Letters | 2015

Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.

Carolyn Diane Dzierba; Yingzhi Bi; Bireshwar Dasgupta; Richard A. Hartz; Vijay T. Ahuja; Giovanni Cianchetta; Godwin Kumi; Li Dong; Saadat Aleem; Cynthia Anne Fink; Yudith Garcia; Michael Alan Green; Jianxin Han; Soojin Kwon; Ying Qiao; Jiancheng Wang; Yulian Zhang; Ying Liu; Greg Zipp; Zhi Liang; Neil T. Burford; Meredith Ferrante; Robert L. Bertekap; Martin A. Lewis; Angela Cacace; James E. Grace; Alan Wilson; Amr Nouraldeen; Ryan Westphal; David S. Kimball

Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties.

Bioorganic & Medicinal Chemistry Letters | 2015

The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders

Yingzhi Bi; Carolyn Diane Dzierba; Cynthia Anne Fink; Yudith Garcia; Michael Alan Green; Jianxin Han; Soojin Kwon; Godwin Kumi; Zhi Liang; Ying Liu; Ying Qiao; Yulian Zhang; Greg Zipp; Neil T. Burford; Meredith Ferrante; Robert L. Bertekap; Martin A. Lewis; Angela Cacace; Ryan Westphal; David S. Kimball; Joanne J. Bronson; John E. Macor

Modulating GPR88 activity is suggested to have therapeutic utility in the treatment of CNS disorders, such as schizophrenia. This Letter will describe the discovery and SAR development of a class of potent GPR88 agonists.

Archive | 2013

PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

Yingzhi Bi; Kenneth G. Carson; Giovanni Cianchetta; Michael Alan Green; Godwin Kumi; Alan Main; Yulian Zhang; Glenn Gregory Zipp

Archive | 2013

IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

Yingzhi Bi; Kenneth G. Carson; Giovanni Cianchetta; Michael Alan Green; Godwin Kumi; Zhi Liang; Ying Jade Liu; Alan Main; Yulian Zhang; Gregory Glenn Zipp

Archive | 2013

Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof

Yingzhi Bi; Kenneth G. Carson; Giovanni Cianchetta; Michael Alan Green; Godwin Kumi; Zhi Liang; Ying Jade Liu; Alan Main; Yulian Zhang; Glenn Gregory Zipp

Archive | 2016

COMPUESTOS A BASE DE PIRAZOLO[1,5-a]PIRIMIDINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO

Yingzhi Bi; Michael Walter Gardyan; Michael Alan Green; Godwin Kumi; Yulian Zhang

Archive | 2016

COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO

Yingzhi Bi; Michael Walter Gardyan; Michael Alan Green; Godwin Kumi; Yulian Zhang

Archive | 2015

INHIBITORS OF ADAPTER ASSOCIATED KINASE 1, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

Yingzhi Bi; Godwin Kumi

Archive | 2014

COMPUESTOS BASADOS EN PIRAZOLO[1,5-A]PIRIMIDINA, COMPOSICIONES QUE LOS COMPRENDEN Y METODOS QUE LOS UTILIZAN

Yingzhi Bi; Kenneth G. Carson; Giovanni Cianchetta; Michael Alan Green; Godwin Kumi; Alan Main; Yulian Zhang; Glenn Gregory Zipp

Archive | 2014

COMPUESTOS BASADOS EN LA IMIDAZO[1,2-B]PIRIDAZINA, COMPOSICIONES QUE LA COMPRENDEN Y METODOS QUE LOS UTILIZAN

Yingzhi Bi; Kenneth G. Carson; Giovanni Cianchetta; Michael Alan Green; Godwin Kumi; Zhi Liang; Ying Jade Liu; Alan Main; Yulian Zhang; Glenn Gregory Zipp

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Collaboration

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Yingzhi Bi

Bristol-Myers Squibb

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Yulian Zhang

Lexicon Pharmaceuticals

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Michael Alan Green

Lexicon Pharmaceuticals

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Giovanni Cianchetta

Lexicon Pharmaceuticals

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Alan Main

Lexicon Pharmaceuticals

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Kenneth G. Carson

Lexicon Pharmaceuticals

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Zhi Liang

Lexicon Pharmaceuticals

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Glenn Gregory Zipp

Lexicon Pharmaceuticals

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Ying Jade Liu

Lexicon Pharmaceuticals

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Angela Cacace

Bristol-Myers Squibb

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