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Yingzhi Bi

Bristol-Myers Squibb

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Publication

Featured researches published by Yingzhi Bi.

Bioorganic & Medicinal Chemistry Letters | 2001

The discovery of novel, potent and selective PDE5 inhibitors

Yingzhi Bi; Patrick Stoy; Leonard P. Adam; Bin He; John Krupinski; Diane E. Normandin; Ron Pongrac; Laurie Seliger; Andrew Watson; John E. Macor

The design and synthesis of a novel scaffold for potent and selective PDE5 inhibitors are described. Compound 3a was more potent (PDE5 IC50=0.31 nM) and selective (>10,000-fold vs PDE1 and 160-fold selective vs PDE6) PDE5 inhibitor than sildenafil.

Endocrinology | 2007

Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats

Jacek Ostrowski; Joyce E. Kuhns; John A. Lupisella; Mark C. Manfredi; Blake C. Beehler; Stanley R. Krystek; Yingzhi Bi; Chongqing Sun; Ramakrishna Seethala; Rajasree Golla; Paul G. Sleph; Aberra Fura; Yongmi An; Kevin Kish; John S. Sack; Kasim A. Mookhtiar; Gary J. Grover; Lawrence G. Hamann

Archive | 2003

Bicyclic modulators of androgen receptor function

Chongqing Sun; Lawrence G. Hamann; David J. Augeri; Yingzhi Bi; Jeffrey A. Robl; Yanting Huang; Tammy C. Wang; Alexandra Holubec; Ligaya M. Simpkins; James C. Sutton; James J. Li

Archive | 2001

Quinoline Inhibitors of cGMP Phosphodiesterase

Yingzhi Bi; Guixue Yu; David P. Rotella; John E. Macor

Archive | 2004

Monocyclic N-aryl hydantoin modulators of androgen receptor function

Yingzhi Bi; Lawrence G. Hamann; Mark C. Manfredi; Ligaya M. Simpkins

Archive | 2005

Sulfonylpyrrolidine modulators of androgen receptor function and method

Lawrence G. Hamann; Yingzhi Bi; Mark C. Manfredi; Alexandra A. Nirschl; James C. Sutton

Bioorganic & Medicinal Chemistry Letters | 2004

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

Yingzhi Bi; Patrick Stoy; Leonard P. Adam; Bin He; John Krupinski; Diane E. Normandin; Ron Pongrac; Laurie Seliger; Andrew Watson; John E. Macor

Bioorganic & Medicinal Chemistry Letters | 2007

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators.

Lawrence G. Hamann; Mark C. Manfredi; Chongqing Sun; Stanley R. Krystek; Yanting Huang; Yingzhi Bi; David J. Augeri; Tammy C. Wang; Yan Zou; David A. Betebenner; Aberra Fura; Ramakrishna Seethala; Rajasree Golla; Joyce E. Kuhns; John A. Lupisella; Celia D'Arienzo; Laura Custer; Jennifer Price; James M. Johnson; Scott A. Biller; Robert Zahler; Jacek Ostrowski

Bioorganic & Medicinal Chemistry Letters | 2007

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.

Mark C. Manfredi; Yingzhi Bi; Alexandra A. Nirschl; James C. Sutton; Ramakrishna Seethala; Rajasree Golla; Blake C. Beehler; Paul G. Sleph; Gary J. Grover; Jacek Ostrowski; Lawrence G. Hamann

Archive | 2010

Modulators of g protein-coupled receptor 88

Carolyn Diane Dzierba; Richard A. Hartz; Yingzhi Bi; Vijay T. Ahuja; Joanne J. Bronson; Kenneth Carson; Giovanni Cianchetta; Michael Green; David Kimball; S. Roy Kimura; Soojin Kwon; John E. Macor; Yulian Zhang; Greg Zipp

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Collaboration

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Lawrence G. Hamann

Bristol-Myers Squibb

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Yulian Zhang

Lexicon Pharmaceuticals

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Mark C. Manfredi

Bristol-Myers Squibb

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Giovanni Cianchetta

Lexicon Pharmaceuticals

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Godwin Kumi

Lexicon Pharmaceuticals

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Michael Alan Green

Lexicon Pharmaceuticals

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James C. Sutton

Bristol-Myers Squibb

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John E. Macor

Bristol-Myers Squibb

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Alan Main

Lexicon Pharmaceuticals

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Alexandra A. Nirschl

Bristol-Myers Squibb

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