Gohu Suzukamo

Structure-activity relationship of optically active 2-(3-pyridyl)thiazolidin-4-ones as a PAF antagonists

Abstract Two sets of optically active 5-substituted-2-(3-pyridyl)thiazolidin-4-ones, highly potent and selective antagonists of platelet activating factor (PAF), displayed apparently different anti-PAF activities between their enantiomers, wherein these activities depend markedly on the absolute configuration of the 2-position in the thiazolidin-4-ones.

A stereoselective synthesis of β,γ-disubstituted allylic alcohols of z-configuration

Abstract Reaction of alkyllithiums 1 with isoprene epoxide 2 gives β,γ-disubstituted allylic alcohols 3 of Z-configuration. The reaction of π-lithiotricyclene as alkyllithium gives α-santalol 5 , which is one of the main constituents in East Indian sandalwood oil.