Haruo Okabe

ESTIMATION OF SILVER-BINDING NUCLEOLAR ORGANIZER REGIONS (AGNORS) IN LYMPHOPROLIFERATIVE DISORDERS OF GASTROINTESTINAL TRACT

We quantified nucleolar organizer regions demonstrable by silver staining technique (AgNORs) in six cases of reactive lymphoid hyperplasia (RLH), and in 14 low-grade B-cell lymphomas (mucosa-associated lymphoid tissue (MALT) 5, centrocytic 3, centroblastic-centrocytic 6) and 49 high-grade B-cell lymphomas (centroblastic 44, immunoblastic 3, Burkitts one, large cell anaplastic one). The pooled mean AgNOR number in low-grade B-cell lymphomas was significantly higher than that in RLH, and significantly lower than that in high-grade B-cell lymphomas. There was a statistically significant difference between RLH versus centroblastic-centrocytic lymphoma in pooled mean AgNOR number and in RLH versus centrocytic lymphoma but not in RLH versus MALT lymphoma. The AgNOR numbers in the cellular components of RLH were also analyzed. The follicle center centroblasts of RLH exhibited a significantly higher pooled mean AgNOR number than other kinds of lymphoid cells in RLH. Furthermore, AgNOR numbers of gastrointestinal lymphomas were compared with those of cellular elements in RLH. There was a statistically significant increased AgNOR number of centroblastic lymphoma when compared with neoplastic centroblasts in centroblastic-centrocytic lymphoma and follicular centroblasts in RLH. By contrast, there was no significant difference in AgNOR numbers between MALT lymphomas and interfollicular lymphocytes, mantle zone lymphocytes or follicular centrocytes in RLH, respectively. This study demonstrated a similar increase when non-Hodgkins B-cell lymphomas in gastrointestinal tract were compared with histogenetically related cellular elements of RLH. AgNOR counting might be useful adjunct in the classification and grading of lymphoproliferative disorders in gastrointestinal tract.

Advanced osteosarcoma of maxilla for which palliative treatment was usefull. Report of a case.

高度に進展した上顎骨肉腫の1例を経験した。患者は32歳女性で, 7年前に左上顎良性骨芽細胞腫の摘出術を受けていた。初診時, 巨大な腫瘤は左顔面全体に及んでいた。生検の結果は骨肉腫であり, MTX大量療法ならびに放射線療法を行ったところ, 腫瘍は縮小し, 姑息療法として減量手術 (腫瘍切除術) を施行した。術後, 腫瘍は静止的であったが, その後右上肺野, 右脳に転移が認められるようになった。右脳転移巣に対して定位的脳放射線療法を行ったが, 呼吸不全により死の転帰をとった。剖検の結果, 右上肺野の他に, 右脳, 心臓, 舌, その他に転移巣が確認された。

Clinicopathological analysis of the mucoepidermoid carcinoma of minor salivary gland.

小唾液腺に発生した粘表皮癌6症例について病理組織学的に検討した。症例はすべて1次症例で, 発症部位は硬口蓋が3例, 頬粘膜が2例, 下歯肉が1例であった。1991年W.H.O.分類にもとつく組織学的分類では, well differentiated typeが3例, poorly differentiated typeが3例で, poorly differentiated typeの1例に頸部リンパ節転移がみられた。治療は外科療法単独症例が5例, 外科・放射線・化学療法を併用した症例が1例であった。現在のところ全例において再発や転移は認められず, 治療後の経過は良好である。