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Helmut Link

Hoffmann-La Roche

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Publication

Featured researches published by Helmut Link.

Chimia | 2003

From the DNA gyrase inhibitor Cyclothialidine to a new class of antibacterial agents

Erwin Goetschi; Peter Angehrn; Hans Gmuender; Paul Hebeisen; Dirk Kostrewa; Helmut Link; Thomas Luebbers; Raffaello Masciadri; Peter Reindl; Fabienne Ricklin; Frank-Peter Theil

Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtuallyneat enzyme inhibitor.

Journal of Medicinal Chemistry | 2004

New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine

Peter Angehrn; Stefan Buchmann; Christoph Funk; Erwin Goetschi; Hans Gmuender; Paul Hebeisen; Dirk Kostrewa; Helmut Link; Thomas Luebbers; Raffaello Masciadri; Joergen Nielsen; Peter Reindl; Fabienne Ricklin; § and Anne Schmitt-Hoffmann; Frank-Peter Theil

Helvetica Chimica Acta | 1977

Synthese und Reaktionen 8‐gliedriger Heterocyclen aus 3‐Dimethylamino‐2,2‐dimethyl‐2H‐azirin und Saccharin bzw. Phthalimid

Stanislav Chaloupka; Piero Vittorelli; Heinz Heimgartner; Hans Schmid; Helmut Link; Karl Bernauer; Willi E. Oberhänsli

Helvetica Chimica Acta | 1976

Herstellung und Reaktionen der valenzpolaromeren Verbindung (4,4-Dimethyl-2-thiazolin-5-dimethyliminium)-2-thiolat ⇌ (1-Dimethylthiocarbamoyl-1-methyl-äthyl)-isothiocyanat aus 3-Dimethyl-amino-2,2-dimethyl-2H-azirin und Schwefelkohlenstoff

Stanislav Chaloupka; Heinz Heimgartner; Hans Schmid; Helmut Link; Peter Schönholzer; Karl Bernauer

Archive | 1988

3-Heterocyclylthiomethyl cephalosporins

Andre Furlenmeier; Erwin Götschi; Paul Hebeisen; Werner Hofheinz; Helmut Link

Helvetica Chimica Acta | 1972

Über die Synthese der Pilocarpus-Alkaloide Isopilosin und Pilocarpin, sowie die absolute Konfiguration des (+)-Isopilosins

Helmut Link; Karl Bernauer

Archive | 1995

Mono or bicyclic DNA gyrase inhibitors.

Jürgen Geiwiz; Erwin Götschi; Paul Hebeisen; Helmut Link; Thomas Lübbers

Archive | 1978

Imidazolidine derivatives, process for their preparation, intermediates for use in this process, pharmaceutical compositions containing them and the use of the active compounds

Karl Bernauer; Helmut Link; Harro Stohler

Helvetica Chimica Acta | 1975

Die Struktur einer stabilen dipolaren Verbindung aus 2,2-Dimethyl-3-dimethylamino-2H-azirin und Benzoylisothiocyanat. Vorläufige Mitteilung†

Ursula Schmid; Heinz Heimgartner; Hans Schmid; Peter Schönholzer; Helmut Link; Karl Bernauer

Helvetica Chimica Acta | 1978

Synthese von 1, 3, 4-Oxadiazolen und 4, 5-Dihydro-1, 2, 4-triazinen aus 3-Dimethylamino-2, 2-dimethyl-2 H-azirin und Carbohydraziden

Helmut Link

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Collaboration

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Karl Bernauer

Hoffmann-La Roche

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Paul Hebeisen

Hoffmann-La Roche

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Heinz Heimgartner

University of Zurich

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Harro Stohler

Hoffmann-La Roche

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Stanislav Chaloupka

University of Zurich

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Hans Schmid

University of Zurich

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Raffaello Masciadri

Hoffmann-La Roche

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Erwin Goetschi

Hoffmann-La Roche

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Renate Mussner

Hoffmann-La Roche

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Wilhelm Klötzer

Hoffmann-La Roche

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