Hideaki Komiya

Estimating Visceral Fat Area by Multifrequency Bioelectrical Impedance

OBJECTIVE We developed a new method of estimating visceral fat area (VFA) using multifrequency bioelectrical impedance (BI). RESEARCH DESIGN AND METHODS We considered abdominal composition as a parallel circuit model composed of VFA and subcutaneous fat area and calculated the impedance of VFA (IPVFA) from this model. The methods were tested against measures of VFA by computed tomography (CT). Multiple regression analysis was performed on 103 participants to estimate VFA. We cross-validated the regression equation against CT-measured VFA in 30 additional participants. RESULTS The regression equation was VFA = 3.57 × sagittal abdominal diameter + 311.97 × waist-to-height ratio + 0.71 × age + 23.93 × sex + 1.57 × IPVFA (250 kHz) − 174.35 (r = 0.904, P < 0.01). We observed a strong correlation by cross-validation (r = 0.905). CONCLUSIONS Our method using BI is a simple and convenient method for accurately estimating VFA.

Association between postprandial remnant-like particle triglyceride (RLP-TG) levels and carotid intima-media thickness (IMT) in Japanese patients with type 2 diabetes: assessment by meal tolerance tests (MTT).

Our study evaluated the relationship between the pathologic changes associated with atherosclerosis, as primarily represented by postprandial remnant-like lipoproteins and carotid intima-media thickness (IMT), in type 2 diabetic patients. Meal tolerance tests (MTT) were performed in 68 patients with type 2 diabetes. The subjects were divided by pre-meal and 2-h postprandial triglyceride (TG) levels into the normotriglyceridemia (NTG) group; the postprandial hypertriglyceridemia (PHTG) group; and the fasting hypertriglyceridemia (FHTG) group. HOMA-R values were significantly higher in the FHTG group than in the NTG group, with the plasma pre-heparin LPL mass and serum adiponectin levels in the FHTG and PHTG groups significantly lower than in the NTG group. One- and two hour postprandial RLP-TG levels were significantly higher in the PHTG group than in the NTG group, while there was no significant difference in postprandial glucose levels between the two groups. The IMT values were significantly higher in both the FHTG and PHTG groups than in the NTG group. Logistics regression analysis of the 1-and 2-h RLP-TG values using IMT as an induced variable showed the odds ratio for high IMT values to be 5.17 (p<0.05) for the 1-h RLP-TG values and 3.01 (p=0.105) for the 2-h RLP-TG values. Our study results suggest that delayed TG metabolism leading to the retention of remnants in type 2 diabetic patients appears to be closely associated with atherosclerosis, and that postprandial hyperlipidemia is an independent risk factor for the early onset of atherosclerosis.

Comparison of the effects of glimepiride and glibenclamide on adipose tissue tumour necrosis factor-alpha mRNA expression and cellularity.

Aim:  The aim of this study was to compare the effects of glimepiride and glibenclamide on tumour necrosis factor (TNF)‐α expression and adipocyte cellularity in spontaneously diabetic, obese rats.