Hiromitsu Kiriyama

0.85-PW, 33-fs Ti:sapphire laser

We have successfully produced a laser pulse with a peak power of 0.85 PW for a pulse duration of 33 fs in a four-stage Ti:sapphire amplifier chain based on chirped-pulse amplification. To our knowledge this result represents the highest peak power pulses yet produced in any Ti:sapphire chirped-pulse amplification system.

High temporal and spatial quality petawatt-class Ti:sapphire chirped-pulse amplification laser system

Optical parametric chirped-pulse amplification (OPCPA) operation with low gain by seeding with high-energy, clean pulses is shown to significantly improve the contrast to better than 10(-10) to 10(-11) in a high-intensity Ti:sapphire laser system that is based on chirped-pulse amplification. In addition to the high-contrast broadband, high-energy output from the final amplifier is achieved with a flat-topped spatial profile of filling factor near 77%. This is the result of pump beam spatial profile homogenization with diffractive optical elements. Final pulse energies exceed 30 J, indicating capability for reaching peak powers in excess of 500 TW.

Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8–2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

Proton acceleration to 40 MeV using a high intensity, high contrast optical parametric chirped-pulse amplification/Ti:sapphire hybrid laser system.

Using a high-contrast (10(10):1) and high-intensity (10(21) W/cm(2)) laser pulse with the duration of 40 fs from an optical parametric chirped-pulse amplification/Ti:sapphire laser, a 40 MeV proton bunch is obtained, which is a record for laser pulse with energy less than 10 J. The efficiency for generation of protons with kinetic energy above 15 MeV is 0.1%.

High-contrast, high-intensity laser pulse generation using a nonlinear preamplifier in a Ti:sapphire laser system

We report a high-contrast, high-intensity Ti:sapphire chirped-pulse amplification system that incorporates a nonlinear preamplifier based on optical parametric chirped-pulse amplification (OPCPA). By cooling the Ti:sapphire crystal in the final amplifier down to 77 K, the chirped-pulses are amplified to 2.9 J at a 10 Hz repetition rate without a thermal lensing effect. Pulse compression down to 19 fs duration obtained after amplification indicates a peak power of 80 TW. With the OPCPA, the temporal contrast is significantly improved to better than 7x10(-9) in a few picoseconds interval prior to the main laser pulse.

Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1×107 Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20±0.11 using protons with a linear energy transfer of 17.1 keV/μm.

High-energy, high-contrast, multiterawatt laser pulses by optical parametric chirped-pulse amplification

We describe a compact, reliable, high-power, and high-contrast noncollinear optical parametric chirped-pulse amplifier system. With a broadband Ti:sapphire oscillator and grating-based stretching and compression, the chirped pulses are amplified from 0.1 nJ to 122 mJ in type I beta-barium borate optical parametric chirped-pulse amplifiers with a total gain of over 10(9) at 10 Hz repetition rate. Pulse compression down to 19-fs duration achieved after amplification indicates a peak power of 3.2 TW at an average power of 0.62 W. The prepulse contrast is measured to be less than 10(-8) on picosecond time scales.

Focusing and spectral enhancement of a repetition-rated, laser-driven, divergent multi-MeV proton beam using permanent quadrupole magnets

A pair of conventional permanent magnet quadrupoles is used to focus a 2.4 MeV laser-driven proton beam at a 1 Hz repetition rate. The magnetic field strengths are 55 and 60 T/m for the first and second quadrupoles, respectively. The proton beam is focused to a spot with a size of less than ∼3×8 mm2 at a distance of 650 mm from the source. This result is in good agreement with the Monte Carlo particle trajectory simulation.

Efficient production of a collimated MeV proton beam from a polyimide target driven by an intense femtosecond laser pulse

High-flux energetic protons whose maximum energies are up to 4MeV are generated by an intense femtosecond titanium:sapphire laser pulse interacting with 7.5, 12.5, and 25μm thick polyimide tape targets. Laser pulse with an energy of 1.7J and with a duration of 34fs is focused with an f/3.4 parabolic mirror giving an intensity of 3×1019Wcm−2. The main pulse to amplified spontaneous emission (ASE) intensity contrast ratio is 2.5×107. The conversion efficiency from the laser energy into the proton kinetic energies is achieved to be ∼3%, which is comparable to or even higher than those achieved in the previous works; using nanometer-thick targets, in combination with the short-pulse lasers that have almost the same pulse width and the intensity but different main pulse to ASE intensity contrast of ∼1010 [Neely et al., Appl. Phys. Lett. 89, 021502 (2006)], in which the authors claim that the main mechanism is target normal sheath acceleration; or using the 7.5μm thick polyimide target, in combination with the ...

Temporal contrast enhancement of petawatt-class laser pulses

We demonstrate the temporal contrast enhancement in a petawatt-class Ti:sapphire chirped-pulse amplification (CPA) laser system. An extra saturable absorber, introduced downstream after a low-gain optical parametric chirped-pulse amplification (OPCPA) preamplifier, has improved the temporal contrast in the system to 1.4×10(12) on the subnanosecond time scale at 70 TW power level. We have achieved 28 J of uncompressed broadband output energy with this system, indicating the potential for reaching peak powers near 600 TW.