Mamiko Nishiuchi

Review of laser-driven ion sources and their applications

For many years, laser-driven ion acceleration, mainly proton acceleration, has been proposed and a number of proof-of-principle experiments have been carried out with lasers whose pulse duration was in the nanosecond range. In the 1990s, ion acceleration in a relativistic plasma was demonstrated with ultra-short pulse lasers based on the chirped pulse amplification technique which can provide not only picosecond or femtosecond laser pulse duration, but simultaneously ultra-high peak power of terawatt to petawatt levels. Starting from the year 2000, several groups demonstrated low transverse emittance, tens of MeV proton beams with a conversion efficiency of up to several percent. The laser-accelerated particle beams have a duration of the order of a few picoseconds at the source, an ultra-high peak current and a broad energy spectrum, which make them suitable for many, including several unique, applications. This paper reviews, firstly, the historical background including the early laser-matter interaction studies on energetic ion acceleration relevant to inertial confinement fusion. Secondly, we describe several implemented and proposed mechanisms of proton and/or ion acceleration driven by ultra-short high-intensity lasers. We pay special attention to relatively simple models of several acceleration regimes. The models connect the laser, plasma and proton/ion beam parameters, predicting important features, such as energy spectral shape, optimum conditions and scalings under these conditions for maximum ion energy, conversion efficiency, etc. The models also suggest possible ways to manipulate the proton/ion beams by tailoring the target and irradiation conditions. Thirdly, we review experimental results on proton/ion acceleration, starting with the description of driving lasers. We list experimental results and show general trends of parameter dependences and compare them with the theoretical predictions and simulations. The fourth topic includes a review of scientific, industrial and medical applications of laser-driven proton or ion sources, some of which have already been established, while the others are yet to be demonstrated. In most applications, the laser-driven ion sources are complementary to the conventional accelerators, exhibiting significantly different properties. Finally, we summarize the paper.

Discovery of Non-Thermal X-Rays from the Northwest Shell of the New SNR RX J1713.7–3946: The Second SN 1006?

We report ASCA results of a featureless X-ray spectrum from RX J1713.7−3946, a new shell-like SNR discovered with the ROSAT all sky survey. The northwest part of RX J1713.7−3946 was in the field of the ASCA Galactic Plane Survey Project and was found to exhibit a shell-like structure. The spectrum, however shows neither line emission nor any signature of a thermal origin. Instead, a power-law model with a photon index of 2.4-2.5 gives reasonable fit to the spectrum, suggesting a non-thermal origin. Together with the similarity to SN1006, we propose that RX J1713.7−3946 is the second example, after SN1006, of a synchrotron X-ray radiation from a shell of SNRs. Since the synchrotron X-rays suggest existence of extremely high energy charged particles in the SNR shell, our discovery should have strong impact on the origin of the cosmic X-rays.

Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8–2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

Proton acceleration to 40 MeV using a high intensity, high contrast optical parametric chirped-pulse amplification/Ti:sapphire hybrid laser system.

Using a high-contrast (10(10):1) and high-intensity (10(21) W/cm(2)) laser pulse with the duration of 40 fs from an optical parametric chirped-pulse amplification/Ti:sapphire laser, a 40 MeV proton bunch is obtained, which is a record for laser pulse with energy less than 10 J. The efficiency for generation of protons with kinetic energy above 15 MeV is 0.1%.

Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1×107 Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20±0.11 using protons with a linear energy transfer of 17.1 keV/μm.

Nature of the Soft Spectral Component in the X-Ray Pulsars SMC X-1 and LMC X-4

We present here the results of an investigation of the pulse-averaged and pulse-phase-resolved energy spectra of two high-luminosity accretion-powered X-ray pulsars SMC X-1 and LMC X-4 made with ASCA. The phase-averaged energy spectra definitely show the presence of a soft excess in both sources. If the soft excess is modeled as a separate blackbody- or thermal-bremsstrahlung-type component, pulse-phase-resolved spectroscopy of SMC X-1 shows that the soft component also has a pulsating nature. The same may be true for LMC X-4, although a very small pulse fraction limits the statistical significance. The pulsating soft component is found to have a nearly sinusoidal profile, dissimilar to the complex profile seen at higher energies, which can be an effect of smearing. Due to the very high luminosity of these sources, the size of the emission zone required for the soft component is large (radius ~300-400 km). We show that the pulsating nature of the soft component is difficult to explain if a thermal origin is assumed for it. We further investigate with alternate models, such as an inversely broken power law or two different power-law components, and find that these models can also be used to explain the excess at low energy. A soft power-law component may be a common feature of accreting X-ray pulsars, which is difficult to detect because most high-mass X-ray binary pulsars are in the Galactic plane and experience large interstellar absorption. In LMC X-4, we have also measured two additional mideclipse times, which confirm the known orbital decay.

Real-Time Optimization of Proton Production by Intense Short-Pulse Laser with Time-of-Flight Measurement

A scheme of the real-time optimization of proton production by an intense short-pulse laser interacting with a foil target was developed using a time-of-flight measurement with a plastic scintillator. Owing to special treatments, the detection of protons using a scintillation counter has become possible under heavy backgrounds such as laser light itself, laser-generated hard X-ray, self-emission light, and electrons from the laser-produced plasma. With such a real-time measurement of protons, the energy spectrum of protons could be obtained shot by shot, and the experimental conditions for optimal proton production could be determined very efficiently.

A Study of the Populations of X-Ray Sources in the Small Magellanic Cloud with ASCA

The Advanced Satellite for Cosmology and Astrophysics (ASCA) has made multiple observations of the Small Magellanic Cloud (SMC). X-ray mosaic images in the soft (0.7-2.0 keV) and hard (2.0-7.0 keV) bands are separately constructed, and the latter provides the first hard X-ray view of the SMC. We extract 39 sources from the two-band images with a criterion of S/N > 5 and conduct timing and spectral analyses for all of these sources. Coherent pulsations are detected from 12 X-ray sources, five of which are new discoveries. Most of the 12 X-ray pulsars are found to exhibit long-term flux variabilities; hence they are likely to be X-ray binary pulsars (XBPs). On the other hand, we classify four supernova remnants (SNRs) as thermal SNRs, because their spectra exhibit emission lines from highly ionized atoms. We find that XBPs and thermal SNRs in the SMC can be clearly separated by their hardness ratio (the ratio of the count rate between the hard and soft bands). Using this empirical grouping, we find many XBP candidates in the SMC, although no pulsations have yet been detected from these sources. Possible implications on the star formation history and evolution of the SMC are presented by a comparison of the source populations in the SMC and our Galaxy.

Focusing and spectral enhancement of a repetition-rated, laser-driven, divergent multi-MeV proton beam using permanent quadrupole magnets

A pair of conventional permanent magnet quadrupoles is used to focus a 2.4 MeV laser-driven proton beam at a 1 Hz repetition rate. The magnetic field strengths are 55 and 60 T/m for the first and second quadrupoles, respectively. The proton beam is focused to a spot with a size of less than ∼3×8 mm2 at a distance of 650 mm from the source. This result is in good agreement with the Monte Carlo particle trajectory simulation.

Efficient production of a collimated MeV proton beam from a polyimide target driven by an intense femtosecond laser pulse

High-flux energetic protons whose maximum energies are up to 4MeV are generated by an intense femtosecond titanium:sapphire laser pulse interacting with 7.5, 12.5, and 25μm thick polyimide tape targets. Laser pulse with an energy of 1.7J and with a duration of 34fs is focused with an f/3.4 parabolic mirror giving an intensity of 3×1019Wcm−2. The main pulse to amplified spontaneous emission (ASE) intensity contrast ratio is 2.5×107. The conversion efficiency from the laser energy into the proton kinetic energies is achieved to be ∼3%, which is comparable to or even higher than those achieved in the previous works; using nanometer-thick targets, in combination with the short-pulse lasers that have almost the same pulse width and the intensity but different main pulse to ASE intensity contrast of ∼1010 [Neely et al., Appl. Phys. Lett. 89, 021502 (2006)], in which the authors claim that the main mechanism is target normal sheath acceleration; or using the 7.5μm thick polyimide target, in combination with the ...