Hiroshi Ihara
Dokkyo Medical University
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Featured researches published by Hiroshi Ihara.
American Journal of Medical Genetics Part A | 2015
Dae Kwang Song; Masayuki Sawada; Shingo Yokota; Kenji Kuroda; Hiroyuki Uenishi; Tetsufumi Kanazawa; Hiroyuki Ogata; Hiroshi Ihara; Toshiro Nagai; Kazutaka Shimoda
Prader–Willi syndrome (PWS) is a neuro‐genetic disorder caused by the absence/loss of expression of one or more paternally expressed genes on chromosome 15 (q11–13). In this study, a comparative analysis of intelligence level and autistic traits was conducted between children with PWS (n = 30; 18 males, 12 females; age = 10.6 ± 2.8 years) and those with Asperger disorder (AD; n = 31; 24 males, 7 females; age = 10.5 ± 3.1 years). The children were compared by age group: lower elementary school age (6–8 years), upper elementary school age (9–12 years), and middle school age (13–15 years). As results, the intelligence levels of children with PWS were significantly lower than those with AD across all age groups. Autistic traits, assessed using the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS), revealed that among elementary school age children, those with PWS had less prominent autistic traits than those with AD, however, among middle school age children, those with PWS and AD showed similar prominence. An analysis of the PARS subscale scores by age group showed that while the profiles of autistic traits for children with PWS differed from those of children with AD at elementary school age, the profiles showed no significant differences between the groups at middle school age. The findings suggest that autistic traits in PWS become gradually more prominent with increasing of age and that these autistic traits differ in their fundamental nature from those observed in AD.
Behavioural Neurology | 2015
Masao Gito; Hiroshi Ihara; Hiroyuki Ogata; Masayuki Sayama; Nobuyuki Murakami; Toshiro Nagai; Tadayuki Ayabe; Yuji Oto; Kazutaka Shimoda
Objectives. This study measured gender differences in Prader-Willi syndrome (PWS) in regard to the severity of behavioral symptoms. Methods. The Food Related Problem Questionnaire (FRPQ), the Aberrant Behavior Checklist Japanese Version, the Childhood Routines Inventory, the Pervasive Developmental Disorders Autism Society Japan Rating Scale, and Japanese ADHD-RS were administered to PWS patients (45 males aged 6 to 58 and 37 females aged 6 to 45). To examine the effects that gender and genotype have on the severity of each symptom, two-way ANOVAs were conducted. Results. Significant interactions were found only in regard to FRPQ scores, such as FRPQ total score (F(1, 78) = 8.43, p < 0.01). The FRPQ of male deletion (DEL) individuals was higher than that of female DEL and male mUPD. The FRPQ of male maternal uniparental disomy (mUPD) was lower than that of female mUPD. Conclusions. In terms of problem behaviors, routines, autistic behaviors, and hyperactivity, no significant differences were found. Food-related behaviors in DEL were more severe in males, although those in mUPD were less severe in males.
American Journal of Medical Genetics Part A | 2018
Yuji Oto; Keiko Matsubara; Tadayuki Ayabe; Masahisa Shiraishi; Nobuyuki Murakami; Hiroshi Ihara; Tomoyo Matsubara; Toshiro Nagai
Deaths among children with Prader–Willi syndrome (PWS) are often related to only mild or moderate upper respiratory tract infections, and many causes of death remain unexplained. Several reports have hypothesized that patients with PWS may experience latent central adrenal insufficiency. However, whether PWS subjects suffer from alteration of the hypothalamus‐pituitary‐adrenal (HPA) axis remains unclear. This study aimed to explore the HPA axis on PWS. We evaluated the HPA axis in 36 PWS patients (24 males, 12 females; age range, 7 months to 12 years; median age 2.0 years; interquartile range [IQR], 1.5–3.4 years) using an insulin tolerance test (ITT) in the morning between 08:00 and 11:00. For comparison, ITT results in 37 age‐matched healthy children evaluated for short stature were used as controls. In PWS patients, basal levels of adrenocorticotropic hormone (ACTH) were 13.5 pg/ml (IQR, 8.3–27.5 pg/ml) and basal levels of cortisol were 18.0 μg/dl (IQR, 14.2–23.7 μg/dl). For all patients, cortisol levels at 60 min after stimulation were within the reference range (>18.1 μg/dl), with a median peak of 41.5 μg/dl (IQR, 32.3–48.6 μg/dl). Among control children, basal level of ACTH and basal and peak levels of cortisol were 10.9 (IQR, 8.5–22.0 pg/ml), 15.6 (IQR, 11.9–21.6 μg/dl), and 27.8 μg/dl (IQR, 23.7–30.5 μg/dl), respectively. Basal and peak levels of cortisol were all within normal ranges, but peak response of cortisol to ITT was delayed in the majority of PWS patients (64%). Although the mechanism remains unclear, this delay may signify the existence of central obstacle in adjustment of the HPA axis.
Behavioural Neurology | 2017
Atsushi Ishii; Hiroshi Ihara; Hiroyuki Ogata; Masayuki Sayama; Masao Gito; Nobuyuki Murakami; Tadayuki Ayabe; Yuji Oto; Asami Takahashi; Toshiro Nagai
The effects of age and genotype were examined, with regard to the severity of aberrant, autistic, and food-related behaviors in Prader-Willi syndrome (PWS), with an emphasis on the contrast between adolescents and young adults. The Aberrant Behavior Checklist Japanese version (ABC-J), the Food Related Problem Questionnaire (FRPQ), and the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) were administered to 65 PWS patients, including 20 adolescents (ages 12 to 17) and 45 young adults (ages 18 to 29). Significant differences (Mann–Whitney U tests) were found in ABC-J (p = 0.004) and PARS (p = 0.021), with lower scores in adolescents than in young adults. While DEL subgroups showed no significant differences between the two age groups in ABC-J (p = 0.063) and PARS (p = 0.134), mUPD subgroups showed a statistically significant difference in terms of ABC-J (p = 0.007). No significant differences were found between adolescents and young adults, in terms of FRPQ (p = 0.163). These results suggest that aberrant and autistic behaviors follow a marked worsening trend from around the age of 18. On the other hand, food-related behaviors give no sign of change at this transitory stage. Young adults with mUPD were found to be significantly more severe than adolescents with mUPD, in terms of aberrant behaviors.
American Journal of Medical Genetics Part A | 2014
Hiroyuki Ogata; Hiroshi Ihara; Nobuyuki Murakami; Masao Gito; Yasuhiro Kido; Toshiro Nagai
Journal of Nursing Education and Practice | 2013
Masao Gito; Hiroshi Ihara; Hiroyuki Ogata
American Journal of Medical Genetics Part A | 2014
Hiroshi Ihara; Hiroyuki Ogata; Masayuki Sayama; Aya Kato; Masao Gito; Nobuyuki Murakami; Yasuhiro Kido; Toshiro Nagai
The international journal of risk and safety in medicine | 2012
Hiroshi Ihara
Dokkyo journal of medical sciences | 2010
Hiroshi Ihara; Hiroyuki Ogata; Aya Inuzuka; Noriko Ohta; Toshiro Nagai
Research in Developmental Disabilities | 2018
Hiroyuki Ogata; Hiroshi Ihara; Masao Gito; Masayuki Sayama; Nobuyuki Murakami; Tadayuki Ayabe; Yuji Oto; Toshiro Nagai; Kazutaka Shimoda