Ho-Fung Chan

Whole lung morphometry with 3D multiple b-value hyperpolarized gas MRI and compressed sensing

To demonstrate three‐dimensional (3D) multiple b‐value diffusion‐weighted (DW) MRI of hyperpolarized 3He gas for whole lung morphometry with compressed sensing (CS).

Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5T: 3He and 129Xe Lung MRI at 1.5T

To support translational lung MRI research with hyperpolarized 129Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from 3He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of 129Xe functional metrics have not been reported.

3D diffusion‐weighted 129Xe MRI for whole lung morphometry

To obtain whole lung morphometry measurements from 129Xe in a single breath‐hold with 3D multiple b‐value 129Xe diffusion‐weighted MRI (DW‐MRI) with an empirically optimized diffusion time and compressed sensing for scan acceleration.

Imaging Collateral Ventilation in Patients With Advanced Chronic Obstructive Pulmonary Disease: Relative Sensitivity of 3He and 129Xe MRI: Letter to the Editor

LEVEL OF EVIDENCE 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

Hyperpolarised Helium-3 (3He) MRI: Physical Methods for Imaging Human Lung Function

Hyperpolarised gas imaging has opened up the possibility of direct imaging of pulmonary ventilation by MRI. The use of hyperpolarised helium-3 (3He) gas for MRI of the lung has been pioneered by a number of groups worldwide. Due to the enormous progress in the fields of hyperpolarisation technology, administration of hyperpolarised 3He, MR hardware, and MR pulse sequences, translation into the clinical arena has been accomplished. This chapter gives an overview of the technical methods for hyperpolarised 3He MRI for human lung imaging, focusing on gas polarisation methods, MR physics, hardware and software considerations, safety considerations for inhaled 3He, and pulse sequence design for probing several aspects of lung physiology and anatomy. Where possible, the methods will be highlighted with reference to the literature and illustrated with clinical examples of images from the authors’ home group. We conclude the chapter with an appraisal of how 3He methods can be translated to the more clinically scalable gas isotope 129Xe and provide preliminary evidence of how the MRI techniques compare between the two gases, in order to lead into the following chapter on hyperpolarised 129Xe techniques.