Ho Song Kang
Hanyang University
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International Journal of Dermatology | 2014
Ho Song Kang; Min Won Lee; Jun Oh Paek; Hee Joon Yu; Joung Soo Kim
Immunotherapy has been used for many years in the treatment of warts. Diphenylcyclopropenone is frequently used as an immunotherapeutic agent.
Annals of Dermatology | 2012
Hyun Chul Park; Ho Song Kang; Kyoung Tae Park; Young Ha Oh; Hee Joon Yu; Joung Soo Kim
Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen disease. A 75-year-old woman presented with a 6-month history of an irregularly shaped erythematous patch on the left mandibular angle. Three months later, a 1.5×1.0 cm sized painless and rapidly growing erythematous nodule developed on the patch. Microscopically, the patch lesion was consistent with that of Bowen disease. The nodular lesion showed a number of small uniform hyperchromatic cells with scanty cytoplasm. It showed dense small-cell like nodular infiltration in the dermis. Immunohistochemical staining for cytokeratin 20 showed a positive result with a dot-like perinuclear pattern. Additionally, the result for thyroid transcription factor-1 was negative, which is positive in small cell neuroendocrine carcinoma. From these findings, we diagnosed this lesion as MCC concurrent with Bowen disease.
Annals of Dermatology | 2011
Jun Oh Paek; Ho Song Kang; Kwang Yeoll Yeo; Hee Joon Yu; Joung Soo Kim
Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless firm mass. A 45-year-old woman presented with a 2-year history of a painless, slowly growing 0.9×0.7 cm sized firm mass in the subcutaneous tissue of the posterior side of the right lower leg. We presumed this lesion to be an epidermal cyst, pilomatricoma or calcinosis cutis and performed an excisional biopsy. The histologic examination showed that it was composed of spindle-shaped myoid-appearing cells in a concentric arrangement, intimately associated with thin-walled vascular channels. Lesional spindle cells were diffusely positive for smooth muscle actin and were negative for CD34, desmin and S100 protein. From these findings, we diagnosed this lesion as a myopericytoma.
Annals of Dermatology | 2014
Ho Song Kang; Jun Oh Paek; Min Won Lee; Hee Joon Yu; Joung Soo Kim
Dear Editor: Anetoderma is a rare cutaneous disorder characterized by localized depressions or the outpouchings of the skin caused by laxity and the weakening of the dermal connective tissue as a result of the focal loss of elastic fibers1. Anetoderma has two forms: primary and secondary. Primary anetoderma develops on clinically normal skin without any preceding dermatoses. Secondary anetoderma develops on exactly the same area as a previous specific pathology1. A 3-month-old girl presented with an increasing number of multiple atrophic and brownish scaly macules on her trunk and both extremities, which had begun to develop 3 weeks previously. She had erythematous asymptomatic papules that changed to brownish scaly macules. On clinical examination, the otherwise healthy-looking girl was presented with 40 to 50 atrophic and round-to-oval shaped brownish macules on her trunk and both extremities (Fig. 1). The lesions were 2 to 10 mm in diameter and were relatively well circumscribed, presenting as depressions below the level of the normal skin. A biopsy was taken from a typical-looking lesion on her leg. Since the clinical features including the lesions and the patients age closely resembled primary anetoderma and looked just like a case we had previously reported, we presumed that this was a case of primary anetoderma. However, a histopathological examination revealed degenerated collagen bundles along with histiocytes, lymphocytes and Touton giant cells in the dermis (Fig. 2A). An alcian blue staining was positive in the degenerated collagen fibers. Fig. 1 Multiple atrophic and brownish scaly macules (black arrows) can be seen on the abdomen (A) and left leg (B). Fig. 2 (A) Skin biopsy showing pale-staining, well-circumscribed, haphazardly arranged degenerated collagen bundles surrounded by inflammatory cells in the dermis (H&E, ×100). (B) Loss of elastic fibers in the superficial and mid dermis (elastic ... The diagnosis was therefore granuloma annulare. The elastic stain also revealed a complete elastolysis or fragmented elastic fibers in the superficial and the mid dermis (Fig. 2B). These findings were consistent with anetoderma. Thus, histopathologic features of granuloma annulare and anetoderma coexisted in this patient. Anetoderma occurs mainly in women aged 20 to 40 years, but is occasionally reported in younger and older patients of both sexes1. It has also occasionally been described/reported in premature infants, which may be related to the use of cutaneous monitoring leads or adhesives1. Granuloma annulare generally resolves spontaneously without leaving any atrophic scars2. However, there are some reported cases manifesting the development of mid-dermal elastolysis and anetoderma following granuloma annulare3,4. Gunes et al.2 found that elastic fiber damage is one of the main accompanying features of granuloma annulare, which may develop from delayed type hypersensitivity. Thus, elastic fiber destruction may be intrinsic to granuloma annulare and can be severe enough to cause visible skin atrophy like anetoderma2,4. In addition, elastolytic enzymes released from inflammatory cells are thought to be responsible for the fragmentation of elastic fibers. Vibronectin and decay acceleration factor have also been implicated5. Anetoderma should be distinguished from several elastolytic disorders including acquired cutis laxa, mid-dermal elastolysis, and perifollicular elastolysis4. Acquired cutis laxa differs from anetoderma by its generally widespread sagging or lax skin. Mid-dermal elastolysis is characterized by wrinkly patches and follicular papules, and the selective loss of elastic fibers limited to the mid dermis. Perifollicular elastolysis are presented as small papules centered around the follicles on the face or the upper back. We report an interesting case of anetoderma developing in generalized granuloma annulare, with the earliest known age of onset and displaying coexisting histopathologic features of granuloma annulare and anetoderma.
Annals of Dermatology | 2011
Ho Song Kang; Jae Hur; Jung Woo Lee; Dae Heon Oh; Kwang Yeoll Yeo; Joung Soo Kim; Hee Joon Yu
Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis and this disease is a genetically determined disturbance of epidermal proliferation. It is characterized by acquired, slowly progressive pigmented lesions that primarily involve the great skin folds and flexural areas such as the axilla, neck, limb flexures, the inframammary area and the inguinal folds. The vulva is an unusual location for DDD. A 41-year-old woman presented with a 10-year history of multiple, small, reticulated and brownish macules distributed symmetrically on the bilateral external genital regions. We found no other similarly pigmented skin lesions on her body, including the flexural areas. There was no known family history of similar eruptions or pigmentary changes. The histologic examination showed irregular rete ridge elongation with a filiform or antler-like pattern and basilar hyperpigmentation on the tips. Fontana-Masson staining showed increased pigmentation of the rete ridges and the S100 protein staining did not reveal an increased number of melanocytes in the epidermis. From these findings, we diagnosed this lesion as DDD.
Annals of Dermatology | 2012
Ho Song Kang; Ha Eun Lee; Young Suck Ro; Chang Woo Lee
Morsicatio labiorum is a form of tissue alteration caused by self-induced injury, mostly occurring on the lips, and is considered to be a rarely encountered mucocutaneous disorder. Clinically, it is a macerated grey-white patch and plaque of the mucosa caused by external stimuli (self-induced injury) such as habitual biting, chewing, or sucking of the lip. It is often confused with other dermatological disorders involving the oral mucosa, which can lead to a misdiagnosis. We herein report three cases of morsicatio labiorum; two cases were misdiagnosed as exfoliative cheilitis at the time of the first visit.
Cutis | 2014
Joung Soo Kim; Jun Oh Paek; Ho Song Kang; Hee Joon Yu
Cutis | 2016
Joung Soo Kim; Min Won Lee; Jun Oh Paek; Ho Song Kang; Hee Joon Yu
Cutis | 2014
Joung Soo Kim; Jeong Mg; Ho Song Kang; Hee Joon Yu
Cutis | 2013
Park Hc; Ho Song Kang; Joung Soo Kim