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Dive into the research topics where Ikuyo Miyake is active.

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Featured researches published by Ikuyo Miyake.


Diabetic Medicine | 2006

IL‐18 gene polymorphism confers susceptibility to the development of anti‐GAD65 antibody in Graves’ disease

Yuji Hiromatsu; Tokunori Mukai; Hiroo Kaku; Ikuyo Miyake; Michiko Ichimura; Tomoka Fukutani; Hitomi Nakayama; K. Takata; Y. Imamura; Shingo Shoji; Kentaro Yamada; Yoshiro Koda; Tomasz Bednarczuk

Aims  This study aimed to investigate whether interleukin‐18 (IL‐18) gene polymorphisms are associated with the development of antibody against the 65‐kDa isoform of recombinant human glutamic acid decarboxylase (GAD65Ab) in patients with Graves’ disease.


European Journal of Nuclear Medicine and Molecular Imaging | 1998

Technetium-99m tetrofosmin imaging in patients with subacute thyroiditis

Yuji Hiromatsu; Masatoshi Ishibashi; Ikuyo Miyake; Kyohei Nonaka

Abstract. We studied the significance of technetium-99m tetrofosmin scintigraphy in patients with subacute thyroiditis (SAT). Six patients with SAT, who had painful goitre with thyrotoxicosis, underwent 99mTc-pertechnetate scintigraphy and 99mTc-tetrofosmin imaging during the acute and recovery stages of SAT. The thyroid uptake ratio of tetrofosmin was compared with the clinical parameters associated with SAT. 99mTc-pertechnetate scintigraphy showed markedly reduced uptake in the thyroid during the acute stage of SAT, suggesting that the appropriate metabolic pathway is not functioning. Conversely, 99mTc-tetrofosmin images showed diffuse increased uptake in the thyroid region on early and delayed imaging. Tetrofosmin images in the acute stage and in the recovery stage of SAT showed different clearance curves for tetrofosmin uptake. The uptake ratio assessed as thyroid uptake/background (T/B) correlated with the serum C-reactive protein concentration. In conclusion, 99mTc-tetrofosmin uptake may reflect the inflammatory process associated with SAT, and thus this tracer may have potential as a marker of disease activity and severity.


The Journal of Clinical Endocrinology and Metabolism | 2007

Cytotoxic T-Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease: A Meta-Analysis

Fotini K. Kavvoura; Takashi Akamizu; Takuya Awata; Yoshiyuki Ban; Dimitry A. Chistiakov; Irena Frydecka; Abbas Ghaderi; S. C. L. Gough; Yuji Hiromatsu; Rafał Płoski; Pei-Wen Wang; Yoshio Ban; Tomasz Bednarczuk; Emma I. Chistiakova; Marcin Chojm; Joanne M. Heward; Hitomi Hiratani; Suh-Hang Hank Juo; Lidia Karabon; Shigehiro Katayama; Susumu Kurihara; Rue-Tsuan Liu; Ikuyo Miyake; Gholamhossein Ranjbar Omrani; Edyta Pawlak; Matsuo Taniyama; Teruaki Tozaki; John P. A. Ioannidis


The Journal of Clinical Endocrinology and Metabolism | 2000

Cytokine profiles in eye muscle tissue and orbital fat tissue from patients with thyroid-associated ophthalmopathy.

Yuji Hiromatsu; Dame Yang; Tomasz Bednarczuk; Ikuyo Miyake; Kyohei Nonaka; Yoichi Inoue


Endocrine Journal | 2005

A C/T polymorphism in the 5' untranslated region of the CD40 gene is associated with later onset of Graves' disease in Japanese.

Tokunori Mukai; Yuji Hiromatsu; Tomoka Fukutani; Michiko Ichimura; Hiroo Kaku; Ikuyo Miyake; Kentaro Yamada


Annals of Nuclear Medicine | 2007

Diffuse and diffuse-plus-focal uptake in the thyroid gland identified by using FDG-PET: prevalence of thyroid cancer and Hashimoto's thyroiditis

Seiji Kurata; Masatoshi Ishibashi; Yuji Hiromatsu; Hayato Kaida; Ikuyo Miyake; Masafumi Uchida; Naofumi Hayabuchi


The Journal of Clinical Endocrinology and Metabolism | 2005

Interleukin-13 Gene Polymorphisms Confer the Susceptibility of Japanese Populations to Graves’ Disease

Yuji Hiromatsu; Tomoka Fukutani; Michiko Ichimura; Tokunori Mukai; Hiroo Kaku; Hitomi Nakayama; Ikuyo Miyake; Shingo Shoji; Yoshiro Koda; Tomasz Bednarczuk


Thyroid | 2008

Associations of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene Polymorphisms with Susceptibility to Graves' Disease in a Japanese Population

Michiko Ichimura; Hiroo Kaku; Tomoka Fukutani; Hirohisa Koga; Tokunori Mukai; Ikuyo Miyake; Kentaro Yamada; Yoshiro Koda; Yuji Hiromatsu


Thyroid | 1999

Color Doppler Ultrasonography in Patients with Subacute Thyroiditis

Yuji Hiromatsu; Masatoshi Ishibashi; Ikuyo Miyake; Eri Soyejima; Kimiko Yamashita; Norimasa Koike; Kyohei Nonaka


Thyroid | 1996

Localization and Clinical Significance of Thyrotropin Receptor mRNA Expression in Orbital Fat and Eye Muscle Tissues from Patients with Thyroid-Associated Ophthalmopathy

Yuji Hiromatsu; Masayuki Sato; Yoichi Inoue; Mari Koga; Ikuyo Miyake; Junko Kameo; Shiro Tokisawa; Damu Yang; Kyohei Nonaka

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Tomasz Bednarczuk

Medical University of Warsaw

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