Tomoka Fukutani
Kurume University
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Featured researches published by Tomoka Fukutani.
PLOS ONE | 2013
Nobuhiko Wada; Toshihiko Hashinaga; Shuichi Otabe; Xiaohong Yuan; Yayoi Kurita; Satomi Kakino; Tsuyoshi Ohoki; Hitomi Nakayama; Tomoka Fukutani; Yuji Tajiri; Kentaro Yamada
Background Adiponectin-transgenic mice had many small adipocytes in both subcutaneous and visceral adipose tissues, and showed higher sensitivity to insulin, longer life span, and reduced chronic inflammation. We hypothesized that adiponectin regulates Wnt signaling in adipocytes and thereby modulates adipocyte proliferation and chronic inflammation in adipose tissue. Materials and Methods We examined the expression of all Wnt ligands and their receptors and the activity of Wnt signaling pathways in visceral adipose tissue from wild-type mice and two lines of adiponectin-transgenic mice. The effects of adiponectin were also investigated in cultured 3T3-L1 cells. Results The Wnt5b, Wnt6, Frizzled 6 (Fzd6), and Fzd9 genes were up-regulated in both lines of transgenic mice, whereas Wnt1, Wnt2, Wnt5a, Wnt9b, Wnt10b, Wnt11, Fzd1, Fzd2, Fzd4, Fzd7, and the Fzd coreceptor low-density-lipoprotein receptor-related protein 6 (Lrp6) were reduced. There was no difference in total β-catenin levels in whole-cell extracts, non-phospho-β-catenin levels in nuclear extracts, or mRNA levels of β-catenin target genes, indicating that hyperadiponectinemia did not affect canonical Wnt signaling. In contrast, phosphorylated calcium/calmodulin-dependent kinase II (p-CaMKII) and phosphorylated Jun N-terminal kinase (p-JNK) were markedly reduced in adipose tissue from the transgenic mice. The adipose tissue of the transgenic mice consisted of many small cells and had increased expression of adiponectin, whereas cyclooxygenase-2 expression was reduced. Wnt5b expression was elevated in preadipocytes of the transgenic mice and decreased in diet-induced obese mice, suggesting a role in adipocyte differentiation. Some Wnt genes, Fzd genes, and p-CaMKII protein were down-regulated in 3T3-L1 cells cultured with a high concentration of adiponectin. Conclusion Chronic hyperadiponectinemia selectively modulated the expression of Wnt ligands, Fzd receptors and LRP coreceptors accompanied by the inhibition of the Wnt/Ca2+ and JNK signaling pathways, which may be involved in the altered adipocyte cellularity, endogenous adiponectin production, and anti-inflammatory action induced by hyperadiponectinemia.
Diabetic Medicine | 2006
Yuji Hiromatsu; Tokunori Mukai; Hiroo Kaku; Ikuyo Miyake; Michiko Ichimura; Tomoka Fukutani; Hitomi Nakayama; K. Takata; Y. Imamura; Shingo Shoji; Kentaro Yamada; Yoshiro Koda; Tomasz Bednarczuk
Aims This study aimed to investigate whether interleukin‐18 (IL‐18) gene polymorphisms are associated with the development of antibody against the 65‐kDa isoform of recombinant human glutamic acid decarboxylase (GAD65Ab) in patients with Graves’ disease.
European Journal of Endocrinology | 2003
Tomasz Bednarczuk; Yuji Hiromatsu; Tomoka Fukutani; Krystian Jażdżewski; Piotr Miskiewicz; Maria Osikowska; Janusz Nauman
American Journal of Physiology-endocrinology and Metabolism | 2007
Shuichi Otabe; Xiaohong Yuan; Tomoka Fukutani; Nobuhiko Wada; Toshihiko Hashinaga; Hitomi Nakayama; Naotoshi Hirota; Kentaro Yamada
Metabolism-clinical and Experimental | 2007
Hitomi Nakayama; Shuichi Otabe; Takato Ueno; Naotoshi Hirota; Xiaohong Yuan; Tomoka Fukutani; Toshihiko Hashinaga; Nobuhiko Wada; Kentaro Yamada
Endocrine Journal | 2005
Tokunori Mukai; Yuji Hiromatsu; Tomoka Fukutani; Michiko Ichimura; Hiroo Kaku; Ikuyo Miyake; Kentaro Yamada
Human Immunology | 2004
Tomasz Bednarczuk; Yuji Hiromatsu; Naoko Seki; Rafał Płoski; Tomoka Fukutani; Alina Kurylowicz; Krystian Jażdżewski; Krzysztof Chojnowski; Kyogo Itoh; Janusz Nauman
The Journal of Clinical Endocrinology and Metabolism | 2005
Yuji Hiromatsu; Tomoka Fukutani; Michiko Ichimura; Tokunori Mukai; Hiroo Kaku; Hitomi Nakayama; Ikuyo Miyake; Shingo Shoji; Yoshiro Koda; Tomasz Bednarczuk
Thyroid | 2008
Michiko Ichimura; Hiroo Kaku; Tomoka Fukutani; Hirohisa Koga; Tokunori Mukai; Ikuyo Miyake; Kentaro Yamada; Yoshiro Koda; Yuji Hiromatsu
Endocrine Journal | 2006
Yuji Hiromatsu; Tomoka Fukutani; Michiko Ichimura; Tokunori Mukai; Hiroo Kaku; Ikuyo Miyake; Kentaro Yamada