Irene Pina Vaz

Antimicrobial Effect and Transdentinal Diffusion of New Intracanal Formulations Containing Nitrofurantoin or Doxycycline

The aim of this study was to investigate in vitro the antimicrobial effect and diffusion against E. faecalis of new intracanal medications on the external root surface. The medications tested were a placebo gel (PC); the new formulations with either 3% nitrofurantoin (NIT) or 3% doxycycline hydrochloride (DX) and 2% chlorhexidine (CHX) gel as positive control. The new formulations were tested using the traditional agar diffusion test (ADT) and an adapted agar diffusion method (AADM), where the teeth were filled with the medications and left to diffuse on agar surface seeded with E. faecalis. In the ADT, the larger zones of microbial growth inhibition were seen in DX, followed by CHX and NIT. In the AADM test only DX and CHX showed antimicrobial effect. Statistically significant differences between groups were observed by the Kruskal-Wallis test (2=47.126; p<0.001). The new intracanal formulations with DX and NIT have demonstrated antimicrobial effect against E. faecalis, but only DX was able to diffuse through the dentinal tubules and exert antimicrobial effect outside the roots.

Complicações que podem surgir durante o Uso do Hipoclorito de Sódio no Tratamento Endodôntico

Resumo A solucao de hipoclorito de sodio, em diferentes concentracoes, e o irrigante mais utilizado durante o tratamento endodontico. Embora a sua utilizacao seja geralmente segura, sequelas graves podem ocorrer quando da sua extrusao para alem do apex do canal radicular, afectando os tecidos periapicais. Neste artigo procura-se alertar o Medico Dentista (e outros profissionais de Saude Oral) para os principais acidentes que podem ocorrer com o uso do hipoclorito de sodio durante o tratamento endodontico.