J. Druey

Eine neue Gruppe blutdrucksenkender Substanzen von besonderem Wirkungscharakter

Several new basic substituted derivatives of phthalazine show a potent depressive action on blood-pressure which is characterized by a gradual beginning and a very long duration. This action is limited to a narrow range of dosages. The substances produce an increase in the renal blood-flow and have “adrenolytic” properties of a special character. This combination effects a mode of action not common to other blood-pressure depressing substances.

Heilmittelchemische Studien in der heterocyclischen Reihe. 6. Mitteilung. Pyridazine III. Derivate des cyclischen Maleinsäure‐ und Citraconsäure‐phenylhydrazids

The reaction of phenylhydrazine with maleic acid anhydride and with citraconic acid anhydride was studied. The cyclic phenylhydrazides (1-phenyl-3-hydroxy-6-pyridazones) obtained in this way served as starting materials for the preparation of substituted 1-phenyl-6-pyridazones. Some of them show analgesic and antipyretic activity.

Wirksamkeit schilddrüsenhemmender Stoffe auf die Xenopusmetamorphose

A number of the compounds which had been shown byAstwood, in experiments on the rat, to have an action on the thyroid, were investigated for their inhibitory effect on the metamorphosis of Xenopus. The same compounds which had been proved to be active in the rat, were also shown, with few exceptions (e. g. p-amino-benzoic acid), to be active in Xenopus. On the other hand several substances which were not active in the rat (e. g. ammonium thiocyanate, thioacetamide) were active in Xenopus. Several of the compounds whichAstwood had described as not especially active or even inactive, proved to be particularly active. N-allylthiourea is about 10–20 times, and N-benzoylthiourea up to 200 times more active than thiourea or thiouracil. Ammonium thiocyanate and thioacetamide, which were found byAstwood to be inactive, showed a higher activity in Xenopus than potassium thiocyanate, which is active in the rat. The possible reasons for these big differences in activity in the rat and in Xenopus are discussed.

Bakteriostatisch wirksame Trichloräthylidenketone

The bacteriostatic action of a series of trichloroethylidene-ketones R-CO-CH=CH-CCl3 is described. Certain compounds, wherein R is a halogen-substituted aromatic ring, are active in a dilution up to 1:4 millions (0.25 mg in a liter) againstStrept. hœm.