Jacqueline Elizabeth Shea
Hammersmith Hospital
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Featured researches published by Jacqueline Elizabeth Shea.
Molecular Microbiology | 1997
Michael Hensel; Jacqueline Elizabeth Shea; Bärbel Raupach; Denise M. Monack; Stanley Falkow; Colin Gleeson; Toru Kubo; David William Holden
We have investigated the structure and transcriptional organization of 13 genes of Salmonella Pathogenicity Island 2 (SPI2) that encode components of the second type III secretion apparatus of Salmonella typhimurium. ssaK, L, M, V, N, O, P, Q, R, S, T, U constitute one operon of 10 kb. ssaJ lies upstream of ssaK and is the terminal gene of another operon. The deduced products of ssaJ, ssaK, ssaV, ssaN, ssaO, ssaQ, ssaR, ssaS, ssaT, and ssaU show greatest similarity to the Yersinia spp. genes yscJ, yscL, lcrD, yscN, yscO, yscQ, yscR, yscS, yscT, and yscU, respectively. The products of the ssaL, ssaM and ssaP genes do not have significant similarity to products of other type III secretion systems, and might be important for the specific function of the SPI2 type III secretion system. Bacterial strains carrying different ssa mutations display minor alterations in terms of serum sensitivity when compared with the wild‐type strain, but none are defective in replication within macrophage‐like RAW 264.7 cells. However, some of the ssa mutant strains invade HEp2 cells less efficiently and are less cytotoxic to RAW 264.7 macrophages than the wild‐type strain. We show that the invasion defect is correlated with a lack of SipC in culture supernatants of these mutant strains. SipC is a product of the SPI1 type III secretion system of S. typhimurium, and is important for epithelial cell invasion. Therefore, mutations in SPI2 can affect the SPI1 secretion system, which raises the possibility of an interaction between the two type III secretion systems.
Proceedings of the National Academy of Sciences of the United States of America | 1996
Jacqueline Elizabeth Shea; Michael Hensel; Colin Gleeson; David W. Holden
Infection and Immunity | 1999
Jacqueline Elizabeth Shea; Carmen R. Beuzón; Colin Gleeson; Rosanna Mundy; David W. Holden
Journal of Bacteriology | 1997
Michael Hensel; Jacqueline Elizabeth Shea; Andreas J. Bäumler; Colin Gleeson; Frederick R. Blattner; David W. Holden
Archive | 2001
Enda Elizabeth Clarke; Liqing Zhou; Jacqueline Elizabeth Shea; Robert Feldman; David William Holden
Archive | 2000
Robert Feldman; Gordon Dougan; Joseph David Santangelo; David William Holden; Jacqueline Elizabeth Shea; Zoë Hindle
Archive | 1995
David William Holden; Jacqueline Elizabeth Shea; Michael Hensel
Archive | 1999
Helen Rachel Crooke; Enda Elizabeth Clarke; Paul Everest; Gordon Dougan; David William Holden; Jacqueline Elizabeth Shea; Robert Feldman
Archive | 1999
Enda Elizabeth Clarke; Helen Rachel Crooke; Gordon Dougan; Paul Everest; Robert Feldman; David William Holden; Jacqueline Elizabeth Shea
Archive | 1999
Michael Hensel; Carlos A. Guzmán; Eva Medina; Heiko Apfel; Christoph Hueck; David William Holden; Jacqueline Elizabeth Shea