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Dive into the research topics where Jacqueline Elizabeth Shea is active.

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Featured researches published by Jacqueline Elizabeth Shea.


Molecular Microbiology | 1997

FUNCTIONAL ANALYSIS OF SSAJ AND THE SSAK/U OPERON, 13 GENES ENCODING COMPONENTS OF THE TYPE III SECRETION APPARATUS OF SALMONELLA PATHOGENICITY ISLAND 2

Michael Hensel; Jacqueline Elizabeth Shea; Bärbel Raupach; Denise M. Monack; Stanley Falkow; Colin Gleeson; Toru Kubo; David William Holden

We have investigated the structure and transcriptional organization of 13 genes of Salmonella Pathogenicity Island 2 (SPI2) that encode components of the second type III secretion apparatus of Salmonella typhimurium. ssaK, L, M, V, N, O, P, Q, R, S, T, U constitute one operon of 10 kb. ssaJ lies upstream of ssaK and is the terminal gene of another operon. The deduced products of ssaJ, ssaK, ssaV, ssaN, ssaO, ssaQ, ssaR, ssaS, ssaT, and ssaU show greatest similarity to the Yersinia spp. genes yscJ, yscL, lcrD, yscN, yscO, yscQ, yscR, yscS, yscT, and yscU, respectively. The products of the ssaL, ssaM and ssaP genes do not have significant similarity to products of other type III secretion systems, and might be important for the specific function of the SPI2 type III secretion system. Bacterial strains carrying different ssa mutations display minor alterations in terms of serum sensitivity when compared with the wild‐type strain, but none are defective in replication within macrophage‐like RAW 264.7 cells. However, some of the ssa mutant strains invade HEp2 cells less efficiently and are less cytotoxic to RAW 264.7 macrophages than the wild‐type strain. We show that the invasion defect is correlated with a lack of SipC in culture supernatants of these mutant strains. SipC is a product of the SPI1 type III secretion system of S. typhimurium, and is important for epithelial cell invasion. Therefore, mutations in SPI2 can affect the SPI1 secretion system, which raises the possibility of an interaction between the two type III secretion systems.


Proceedings of the National Academy of Sciences of the United States of America | 1996

Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium

Jacqueline Elizabeth Shea; Michael Hensel; Colin Gleeson; David W. Holden


Infection and Immunity | 1999

Influence of the Salmonella typhimurium Pathogenicity Island 2 Type III Secretion System on Bacterial Growth in the Mouse

Jacqueline Elizabeth Shea; Carmen R. Beuzón; Colin Gleeson; Rosanna Mundy; David W. Holden


Journal of Bacteriology | 1997

Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12.

Michael Hensel; Jacqueline Elizabeth Shea; Andreas J. Bäumler; Colin Gleeson; Frederick R. Blattner; David W. Holden


Archive | 2001

Virulence genes proteins and their use

Enda Elizabeth Clarke; Liqing Zhou; Jacqueline Elizabeth Shea; Robert Feldman; David William Holden


Archive | 2000

Attenuated microorganisms for the treatment of infection

Robert Feldman; Gordon Dougan; Joseph David Santangelo; David William Holden; Jacqueline Elizabeth Shea; Zoë Hindle


Archive | 1995

Virulence genes in the VGC2 cluster of Salmonella

David William Holden; Jacqueline Elizabeth Shea; Michael Hensel


Archive | 1999

Virulence genes and proteins, and their use

Helen Rachel Crooke; Enda Elizabeth Clarke; Paul Everest; Gordon Dougan; David William Holden; Jacqueline Elizabeth Shea; Robert Feldman


Archive | 1999

Virulenzgene und -proteine und deren Verwendung Virulence genes and proteins and their use

Enda Elizabeth Clarke; Helen Rachel Crooke; Gordon Dougan; Paul Everest; Robert Feldman; David William Holden; Jacqueline Elizabeth Shea


Archive | 1999

Attenuated cells comprising sp12 mutants, carriers and compositions containing same, methods of production and uses thereof

Michael Hensel; Carlos A. Guzmán; Eva Medina; Heiko Apfel; Christoph Hueck; David William Holden; Jacqueline Elizabeth Shea

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Gordon Dougan

Wellcome Trust Sanger Institute

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