Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Michael Hensel is active.

Publication


Featured researches published by Michael Hensel.


Cancer Gene Therapy | 2002

Salmonella pathogenicity island-2 and anticancer activity in mice

John M. Pawelek; Stefano Sodi; Ashok K. Chakraborty; James T. Platt; Samuel Miller; David W Holden; Michael Hensel; K. Brooks Low

Salmonella enterica servovar Typhimurium is capable of targeting, colonizing, and eliciting growth suppression of tumors in mice. We examined the effects of mutations on this anticancer phenotype in two Salmonella virulence gene clusters. Salmonella pathogenicity island (SPI)-1 genes promote systemic invasion from the intestine, whereas SPI-2 genes support systemic survival within macrophages and other cells. Disabling SPI-1 (prgH−) strongly reduced invasion in vitro, but had no effect on tumor growth suppression in vivo. However, disabling SPI-2 (ssaT−) ablated tumor growth suppression. In addition to ssaT−, mutations in SPI-2 genes sseA, sseB, sseC, sscA, and ssrA also eliminated antitumor activity, whereas mutations in sseF or sseG yielded partial loss of function. Impaired tumor amplification was seen in three SPI-2 mutants tested after intravenous or intratumoral injection. A SPI-2− strain was unable to suppress tumor growth in CD18-deficient mice with defective macrophages and neutrophils, suggesting that loss of tumor growth suppression in wild-type mice by SPI-2 mutants was not solely a function of increased susceptibility to immune attack. Thus, SPI-2 is essential for the Salmonella antitumor effects, perhaps by aiding bacterial amplification within tumors, and is the first identified genetic system for this Salmonella phenotype.


Archive | 1995

Virulence genes in the VGC2 cluster of Salmonella

David William Holden; Jacqueline Elizabeth Shea; Michael Hensel


Archive | 1999

Attenuated cells comprising sp12 mutants, carriers and compositions containing same, methods of production and uses thereof

Michael Hensel; Carlos A. Guzmán; Eva Medina; Heiko Apfel; Christoph Hueck; David William Holden; Jacqueline Elizabeth Shea


Archive | 1999

Abgeschwächte Salmonella SP12 Mutante als Antigen-Träger. Attenuated Salmonella mutant SP12 as antigen carriers.

Michael Hensel; Carlos A. Guzmán; Eva Medina; Heiko Apfel; Christoph Hueck; David William Holden; Jacqueline Elizabeth Shea


Archive | 1999

Attenuierte salmonella spi2 mutante als antigen-träger

Michael Hensel; Carlos A. Guzmán; Eva Medina; Heiko Apfel; Christoph Hueck; David William Holden; Jacqueline Elizabeth Shea


Archive | 1999

Attenuierte salmonella spi2 mutante als antigen-träger Attenuated salmonella spi2 mutant as antigen-carrier

Michael Hensel; Carlos A. Guzmán; Eva Medina; Heiko Apfel; Christoph Hueck; David William Holden; Jacqueline Elizabeth Shea


Archive | 1999

Attenuated Salmonella mutant SP12 as antigen carriers.

Michael Hensel; Carlos A. Guzmán; Eva Medina; Heiko Apfel; Christoph Hueck; David William Holden; Jacqueline Elizabeth Shea


Archive | 1996

Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium (bacterial pathogenesisypathogenicity islandymurine typhoidysecretionysignature-tagged mutagenesis)

Jacqueline Elizabeth Shea; Michael Hensel; Colin Gleeson; David William Holden


Archive | 1995

Virulenzgene in der VGC2-Region von Salmonella

David William Holden; Jacqueline Elizabeth Shea; Michael Hensel


Archive | 1995

Virulenzgene in der VGC2-Region von Salmonella Virulence genes in the VGC2 region of Salmonella

David William Holden; Jacqueline Elizabeth Shea; Michael Hensel

Collaboration


Dive into the Michael Hensel's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge