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James M. Kress

Hoffmann-La Roche

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Publication

Featured researches published by James M. Kress.

Bioorganic & Medicinal Chemistry Letters | 2010

Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism.

Ralph New Harris; Russel Stephen Stabler; David Bruce Repke; James M. Kress; Keith Adrian Murray Walker; Renee Sharon Martin; Mariola Ilnicka; Simon W. Lee; Tara Mirzadegan

A series of 5-HT(6) ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several non-basic analogs having sub-nanomolar affinity. Ligand structure-activity relationships, receptor point mutation studies, and molecular modeling of these novel ligands all combined to reveal a new alternative binding mode to 5-HT(6) for antagonism.

Bioorganic & Medicinal Chemistry Letters | 2004

Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors

Jeffrey Allen Campbell; Viola Bordunov; Chris Allen Broka; Michelle F. Browner; James M. Kress; Tara Mirzadegan; Chakk Ramesha; Bong F. Sanpablo; Russell Stephen Stabler; Patricia Takahara; Armando G. Villaseñor; Keith Adrian Murray Walker; Jin-Hai Wang; Mary Welch; Paul Weller

Tetrahedron Letters | 2004

Preparation of 3-arylmethylindoles as selective COX-2 inhibitors

Jeffrey Allen Campbell; Viola Bordunov; Chris Allen Broka; John W. Dankwardt; Robert Than Hendricks; James M. Kress; Keith Adrian Murray Walker; Jin-Hai Wang

Archive | 2005

Tetralin and indane derivatives and uses thereof

Ralph New Harris; Nancy Elisabeth Krauss; James M. Kress; David Bruce Repke; Russell Stephen Stabler

Archive | 2006

Dibenzoxazepinone derivatives and uses thereof

Ralph New Harris; James M. Kress; David Bruce Repke; Russell Stephen Stabler

Archive | 2007

Arylsulfonamidyl tetralin derivatives and uses thereof

Ralph New Harris; James M. Kress; David Bruce Repke; Russell Stephen Stabler

Archive | 2006

4-aryloxy quinoline derivatives as 5-ht6 modulators

Iii Ralph New Harris; James M. Kress; David Bruce Repke; Russel Stephen Stabler

Archive | 2006

Aryloxy quinolines and uses thereof

Ralph New Harris; James M. Kress; David Bruce Repke; Russell Stephen Stabler

Archive | 2006

Aryloxy quinolines et leur utilisation en tant que 5-ht6

Iii Ralph New Harris; James M. Kress; David B. Repke; Russel Stephen Stabler

Archive | 2006

4-aryloxy-chinolin-derivate als 5-ht6-modulatoren

Iii Ralph New Harris; James M. Kress; David Bruce Repke; Russel Stephen Stabler

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Collaboration

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Ralph New Harris

Hoffmann-La Roche

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Russel Stephen Stabler

Hoffmann-La Roche

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David Bruce Repke

Hoffmann-La Roche

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Nancy Elisabeth Krauss

Hoffmann-La Roche

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Russell Stephen Stabler

Hoffmann-La Roche

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Keith Adrian Murray Walker

Hoffmann-La Roche

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Chris Allen Broka

Hoffmann-La Roche

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Iii Ralph New Harris

Hoffmann-La Roche

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Jeffrey Allen Campbell

Hoffmann-La Roche

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Jin-Hai Wang

Hoffmann-La Roche

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