Ralph New Harris
Hoffmann-La Roche
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Publication
Featured researches published by Ralph New Harris.
Bioorganic & Medicinal Chemistry Letters | 2010
Ralph New Harris; Russel Stephen Stabler; David Bruce Repke; James M. Kress; Keith Adrian Murray Walker; Renee Sharon Martin; Mariola Ilnicka; Simon W. Lee; Tara Mirzadegan
A series of 5-HT(6) ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several non-basic analogs having sub-nanomolar affinity. Ligand structure-activity relationships, receptor point mutation studies, and molecular modeling of these novel ligands all combined to reveal a new alternative binding mode to 5-HT(6) for antagonism.
Archive | 2002
Colin Charles Beard; Robin Douglas Clark; Lawrence E. Fisher; Ralph New Harris; David Bruce Repke
Archive | 2002
Andrew John Briggs; Robin D. Clark; Ralph New Harris; David B. Repke; Douglas Leslie Wren
Archive | 2003
Robin Douglas Clark; Ralph New Harris; David Bruce Repke
Archive | 2005
Ralph New Harris; Nancy Elisabeth Krauss; James M. Kress; David Bruce Repke; Russell Stephen Stabler
Archive | 2001
Charles Alois Dvorak; Lawrence E. Fisher; Keena Lynn Green; Ralph New Harris; Hans Maag; Anthony Prince; David Bruce Repke; Russell Stephen Stabler
Archive | 1999
Joan M. Caroon; Robin D. Clark; Michael Patrick Dillon; Ralph New Harris; Sharathchandra Surendra Hegde; Clara Jeou Jen Lin; Hans Maag; David B. Repke
Archive | 2002
Colin Charles Beard; Robin D. Clark; Lawrence E. Fisher; Ralph New Harris; David B. Repke; David George Putman
Archive | 1999
Joan M. Caroon; Robin Douglas Clark; Michael Patrick Dillon; Ralph New Harris; Sharathchandra Surendra Hegde; Clara Jeou Jen Lin; Hans Maag; David Bruce Repke
Archive | 2003
Robin Douglas Clark; Ralph New Harris; David Bruce Repke
