Is this you? Create Your Porfile
Avatar

David Bruce Repke

Hoffmann-La Roche

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where David Bruce Repke is active.

Explore More

Publication

Featured researches published by David Bruce Repke.

Bioorganic & Medicinal Chemistry Letters | 2010

Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism.

Ralph New Harris; Russel Stephen Stabler; David Bruce Repke; James M. Kress; Keith Adrian Murray Walker; Renee Sharon Martin; Mariola Ilnicka; Simon W. Lee; Tara Mirzadegan

A series of 5-HT(6) ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several non-basic analogs having sub-nanomolar affinity. Ligand structure-activity relationships, receptor point mutation studies, and molecular modeling of these novel ligands all combined to reveal a new alternative binding mode to 5-HT(6) for antagonism.

Heterocycles | 1984

THE LEIMGRUBER-BATCHO INDOLE SYNTHESIS

Robin D. Clark; David Bruce Repke

Journal of Medicinal Chemistry | 1983

Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones

Robin D. Clark; Joan M. Caroon; Arthur F. Kluge; David Bruce Repke; Adolph P. Roszkowski; Arthur M. Strosberg; Stephen J. Baker; Susan M. Bitter; Marlys D. Okada

Archive | 2002

New indole derivatives with 5-HT6 receptor affinity

Colin Charles Beard; Robin Douglas Clark; Lawrence E. Fisher; Ralph New Harris; David Bruce Repke

Journal of Medicinal Chemistry | 1982

Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists.

Joan M. Caroon; Robin Douglas Clark; Arthur F. Kluge; Ronald Olah; David Bruce Repke; Stefan H. Unger; Anton D. Michel; Roger L. Whiting

Archive | 2003

4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity

Robin Douglas Clark; Ralph New Harris; David Bruce Repke

Archive | 2005

Tetralin and indane derivatives and uses thereof

Ralph New Harris; Nancy Elisabeth Krauss; James M. Kress; David Bruce Repke; Russell Stephen Stabler

Journal of Medicinal Chemistry | 1985

Psychotomimetic N-Methyl-N-isopropyltryptamines. Effects of Variation of Aromatic Oxygen Substituents

David Bruce Repke; Douglas B. Grotjahn; Alexander T. Shulgin

Archive | 2001

Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists

Charles Alois Dvorak; Lawrence E. Fisher; Keena Lynn Green; Ralph New Harris; Hans Maag; Anthony Prince; David Bruce Repke; Russell Stephen Stabler

ChemInform | 1984

Antihypertensive 9‐Substituted l‐Oxa‐4,9‐diazaspiro[5.5]undecan‐3‐ones.

Robin D. Clark; Joan M. Caroon; David Bruce Repke; Arthur M. Strosberg; Susan M. Bitter; Marlys D. Okada; Anton D. Michel; Roger L. Whiting

Explore More

Collaboration

Dive into the David Bruce Repke's collaboration.

Top Co-Authors
Avatar

Ralph New Harris

Hoffmann-La Roche

View shared research outputs
Top Co-Authors
Avatar

Russell Stephen Stabler

Hoffmann-La Roche

View shared research outputs
Top Co-Authors
Avatar

James M. Kress

Hoffmann-La Roche

View shared research outputs
Top Co-Authors
Avatar

Joan M. Caroon

Hoffmann-La Roche

View shared research outputs
Top Co-Authors
Avatar

Robin D. Clark

University of California

View shared research outputs
Top Co-Authors
Avatar

Robin Douglas Clark

Hoffmann-La Roche

View shared research outputs
Top Co-Authors
Avatar

Russel Stephen Stabler

Hoffmann-La Roche

View shared research outputs
Top Co-Authors
Avatar

Anton D. Michel

University of Hertfordshire

View shared research outputs
Top Co-Authors
Avatar

Hans Maag

Hoffmann-La Roche

View shared research outputs
Top Co-Authors
Avatar

Keith Adrian Murray Walker

Hoffmann-La Roche

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge