Jeffrey B. Stambough

Acute cauda equina syndrome after total knee arthroplasty as a result of epidural anesthesia and spinal stenosis.

An unusual complication of epidural anesthesia performed for routine total knee arthroplasty is presented. Epidural catheter placement or removal resulted in an acute cauda equina syndrome in a patient with asymptomatic high-grade lumbar spinal stenosis at L3-4. The case is presented along with a literature review.

Increased risk of failure following revision total knee replacement in patients aged 55 years and younger

The aims of this retrospective study were to compare the mid-term outcomes following revision total knee replacement (TKR) in 76 patients (81 knees) < 55 years of age with those of a matched group of primary TKRs based on age, BMI, gender and comorbid conditions. We report the activity levels, functional scores, rates of revision and complications. Compared with patients undergoing primary TKR, those undergoing revision TKR had less improvement in the mean Knee Society function scores (8.14 (-55 to +60) vs 23.3 points (-40 to +80), p < 0.001), a similar improvement in UCLA activity level (p = 0.52), and similar minor complication rates (16% vs 13%, p = 0.83) at a mean follow-up of 4.6 years (2 to 13.4). Further revision surgery was more common among revised TKRs (17% vs 5%, p = 0.02), with deep infection and instability being the most common reasons for failure. As many as one-third of patients aged < 55 years in the revision group had a complication or failure requiring further surgery. Young patients undergoing revision TKR should be counselled that they can expect somewhat less improvement and a higher risk of complications than occur after primary TKR.

Long-Term Results of Total Hip Arthroplasty with 28-Millimeter Cobalt-Chromium Femoral Heads on Highly Cross-Linked Polyethylene in Patients 50 Years and Less

Highly cross-linked polyethylene (HXLPE) is the most commonly used bearing surface in total hip arthroplasty (THA) because of its superior wear properties, but long-term results in young patients are limited. We report on the clinical outcome, radiographic wear patterns and survivorship of 72 patients ≤50 years old who had a 28-millimeter cobalt-chromium femoral head on HXLPE acetabular liner. Mean and median true linear wear rates at average ten-year follow-up were 0.0104 and 0.01 mm per year ± 0.07 mm. Mean and median two-dimensional volumetric wear rates were 12.79 mm(3) and 5.834 mm(3) per year ± 26.1mm(3) as determined by Martell analysis. As a result of the minimal wear profile, there was no evidence of radiographic osteolysis and no wear-related revisions.

The Inadequacy of Short Knee Radiographs in Evaluating Coronal Alignment After Total Knee Arthroplasty.

BACKGROUND Prior studies have associated coronal alignment after total knee arthroplasty (TKA) with implant survivorship. Results have been based on either the femorotibial angle (FTA) on a short knee film or the hip-knee-ankle angle (HKA) on a full-length radiograph. The purpose of this study was to determine if the FTA on short knee radiographs can accurately predict the true HKA alignment after TKA. METHODS Two orthopedic surgeons measured the FTA, HKA, medial proximal tibial angle, and lateral distal femoral angle in 262 patients who had both short and full-length standing radiographs before and/or after primary TKA. Overall coronal alignment was considered neutral if the FTA was between 2.4° and 7.2° on short knee x-rays or if the HKA was between -3° and 3° on full-length films. RESULTS Preoperatively, 13.9% (26/187) of knees had a neutral FTA on short films, but 50% (13/26) of those were in varus or valgus on full-length films. Postoperatively, 51.4% (106/206) of knees had a neutral FTA on short films, but 27.4% (29/106) of those knees were in varus or valgus on full-length films. When comparing alignment classifications (neutral, varus, or valgus) based on the short vs full-length images, 13.9% (26/187) of patients had discordant classifications on preoperative imaging, and 33.0% (68/206) had discordant classifications on postoperative imaging. CONCLUSION A significant proportion of patients were misclassified as varus, valgus, or neutral based on the FTA when compared to the HKA. Short knee x-rays serve as an inaccurate proxy for full-length films when assessing coronal alignment after TKA.

Contemporary Surgical Indications and Referral Trends in Revision Total Hip Arthroplasty: A 10-Year Review

BACKGROUND Revision total hip arthroplasty (THA) represents nearly 15% of all hip arthroplasty procedures in the United States and is projected to increase. The purpose of our study was to summarize the contemporary indications for revision THA surgery at a tertiary referral medical center. We also sought to identify the indications for early and late revision surgery and define the prevalence of outside institution referral for revision THA. METHODS Using our institutions arthroplasty registry, we identified a retrospective cohort of 870 consecutive patients who underwent revision THA at our hospital from 2004 to 2014. Records were reviewed to collect data on patients primary and revision THA procedures, and the interval between primary THA and revision surgery was determined. RESULTS Aseptic loosening (31.3%), osteolysis (21.8%), and instability (21.4%) were the overall most common indications for revision THA and the most common indications for revision surgery within 5 years of primary THA. Aseptic loosening and osteolysis were the most common indications for revision greater than 5 years from primary THA. Only 16.4% of revised hips had their index arthroplasty performed at our hospital, whereas 83.6% were referred to our institution. CONCLUSIONS Aseptic loosening, osteolysis, and instability remain the most common contemporary indications for revision THA in an era of alternative bearings and modular components. Most of our revisions were referred from outside institutions, which highlights the transfer of a large portion of the revision THA burden to tertiary referral centers, a pattern that could be exacerbated under future bundled payment models.

Instrumented one and two level posterolateral fusions with recombinant human bone morphogenetic protein-2 and allograft: a computed tomography study.

Study Design. Prospective analysis of patients fused with freeze-dried corticancellous allograft, local bone graft, and recombinant human bone morphogenetic protein (rhBMP-2) (Infuse) studied for a minimum follow-up of 24 months. Objectives. To assess the fusion rates of the allograft and Infuse using plain radiographs and reconstructed computed tomography (CT) scans. Outcome measures included Oswestry Disability Index, Verbal Rating Pain Scale for back and leg pain, and SF-36 Health Survey as well as complications. Summary of Background Data. The “gold standard” for arthrodesis of the lumbar spine includes the use of autogenous iliac crest bone graft. Morbidity associated with this harvest is well established. Alternatives to autogenous iliac crest bone graft harvest are being sought both to improve and match arthrodesis rate and secondarily to decrease donor site morbidity. Methods. A prospective consecutive series of 36 patients treated for lumbar acquired spinal stenosis and degenerative disc disease leading to instrumented 1 and 2 level fusions were studied. These patients were arthrodesed with rhBMP-2 and freeze-dried corticancellous allograft and limited amounts of local autogenous bone graft. Results. Fusion by reconstructed coronal and saggittal CT analysis occurred in 97.2% of the cases. The Oswestry Disability Index, Verbal Rating Pain Scale, and SF-36 Health Survey were statistically improved (P < 0.05) from preoperative to final postoperative values. Complications were limited and unrelated to rhBMP-2 and the absorbable collagen sponge. Conclusion. rhBMP-2 (Infuse) at a dose of 12 mg/1.5 mg/mL combined with freeze-dried corticancellous allograft and local autogenous spinous process and lamina bone resulted in new bone formation (fusion) as determined by CT scan. In this preliminary study, fusion rates were 97.2% with consistent posterolateral bone formation. Outcomes and complications are consistent with other studies of this type.

Comparison of contemporary periacetabular osteotomy for hip dysplasia with total hip arthroplasty for hip osteoarthritis

We report patient-reported outcomes and complications associated with contemporary periacetabular osteotomy (PAO) surgery in treating symptomatic acetabular dysplasia and compare these outcomes with total hip arthroplasty (THA) in patients with similar demographic details. Two consecutive cohorts included patients between aged 18 to 40 years who had undergone either PAO (100 hips; 24 male, 76 female) or THA (55 hips; 18 male, 37 female). At a mean follow-up of 5.9 years (2 to 13), there was significant improvement in the modified Harris hip pain (p < 0.001, PAO and p < 0.001, THA), function (p < 0.001, PAO and p = 0.001, THA), and total scores (p < 0.001, PAO and p < 0.001, THA) within each cohort. There were no significant differences in the clinical outcome scores between the groups. Complication rates were low and similar in each cohort (p = 0.68). Similar to THA, contemporary PAO surgery is a clinically effective procedure that improves function and activity levels, provides pain relief and is associated with an acceptable complication rate.

Conversion of a failed hip resurfacing arthroplasty to total hip arthroplasty: pearls and pitfalls.

Surface replacement arthroplasty (SRA) remains a viable alternative to total hip arthroplasty (THA) in appropriately selected, active adults with degenerative hip disease. However, orthopedic surgeons are facing a number of scenarios where revision of one or both components of an SRA is indicated. Indications for revision vary and impact the potential outcomes of conversion of a SRA to THA. While clinical outcomes are generally favorable, a growing body of data illustrates patients who undergo conversion of a SRA to THA to be at increased risk of requiring a repeat revision surgery and experiencing functional outcomes inferior to that of a primary THA. The results of patients undergoing conversion of a SRA to THA highlight the need for careful patient selection, thorough preoperative counseling, and technical precision when performing a SRA. Furthermore, a systematic approach to the failed SRA is necessary to ensure optimal clinical results.

T1rho Magnetic Resonance Imaging at 3T Detects Knee Cartilage Changes After Viscosupplementation.

Viscosupplementation may affect cartilage. Changes in T1rho magnetic resonance imaging (MRI) relaxation times correlate with proteoglycan changes in cartilage. The authors hypothesized that T1rho MRI will show an improvement in proteoglycan content at 6 weeks and 3 months after viscosupplementation and that this improvement will correlate with functional outcome scores. Ten patients (mean age, 56 years; Kellgren-Lawrence grade 1 or 2) underwent T1rho MRI at baseline, 6 weeks, and 3 months after viscosupplementation. Volumetric T1rho means were calculated by depth and region. Visual analog scale (VAS), International Knee Documentation Committee (IKDC), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were obtained. Mean T1rho values decreased in the superficial patella at 6 weeks (10.3%, P=.002) and 3 months (7.9%, P=.018) and in the middle patella at 6 weeks (7.0%, P=.014) compared with baseline values. Deep patella T1rho values increased at 3 months compared with 6 weeks (9.9%, P=.033), returning to values similar to baseline. Mean T1rho values increased in the deep tibia at 6 weeks (4.7%, P=.048) and in the middle tibia (5.2%, P=.004) and deep tibia (11.2%, P=.002) at 3 months compared with baseline. At 6 weeks, improvement was seen in VAS (5.9 to 3.9, P<.01), IKDC-9 (55.3 to 63.7, P=.03), and WOMAC (43.9 to 32.8, P=.03) scores. Functional VAS (4.0, P=.02), IKDC-9 (67.8, P=.04), and WOMAC (30.0, P=.04) scores remained better at 3 months. T1rho MRI is a feasible noninvasive method of studying molecular changes in cartilage. Some segments improved after viscosupplementation, and others worsened, possibly reflecting natural history or symptom relief and subsequent increase in activity-related wear.

Knee Pain and Activity Outcomes After Femoral Derotation Osteotomy for Excessive Femoral Anteversion.

Background: Excessive femoral anteversion is a developmental condition that can become symptomatic into adolescence and manifest as anterior knee pain, tripping, and or problems with sports. Femoral derotational osteotomy about an antegrade intramedullary nail (IMN) is an accepted option to treat this condition. This is the first report of the clinical and functional outcomes of treatment of excessive anteversion with femoral derotational osteotomy stabilized with an IMN. Methods: We prospectively enrolled 28 consecutive patients between 2013 and 2014 who underwent derotational osteotomy. Physical examination measures were used to calculate the amount of angular correction with focus on internal and external rotation of the hip, as well as the trochanteric prominence angle test of femoral anteversion. The International Knee Documentation Committee-9, Marx, and Tegner activity scales were 3 patient-reported outcomes recorded. Results: After femoral derotation osteotomy over an IMN, femoral anteversion, as measured by the trochanteric prominence angle, improved an average of 29 degrees (P<0.0001). At 1-year minimum follow-up, 22 of 28 subjects (78.5%) demonstrated a mean significant improvement of 13 points for International Knee Documentation Committee-9 (SD=15.4, P=0.0007), which surpassed the level of minimal clinically important change. Furthermore, the Tegner inventory scores for the cohort improved by an average of 1.9 activity levels (SD=2.4, P=0.0012). Conclusions: For adolescents with symptomatic excessive femoral anteversion, derotational osteotomy over an IMN offers a reliable surgical option that provides predictable deformity correction and significant improvements in both function and pain scales. Levels of Evidence: Level II—prospective, consecutive, nonrandomized, internally controlled cohort study.