Jennifer S. Gillespie

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Featured researches published by Jennifer S. Gillespie.

Clinical Pharmacology & Therapeutics | 2005

Effect of Tadalafil on Cytochrome P450 3A4–mediated Clearance: Studies in Vitro and in Vivo

Barbara J. Ring; Beverley E. Patterson; Malcolm I. Mitchell; Mark Vandenbranden; Jennifer S. Gillespie; Alun Bedding; Hayley Jewell; Christopher D. Payne; S. Thomas Forgue; James A. Eckstein; Steven A. Wrighton; Diane L. Phillips

Tadalafil was examined in vitro and in vivo for its ability to affect human cytochrome P450 (CYP) 3A‐mediated metabolism.

Journal of Pharmacology and Experimental Therapeutics | 1998

Further Characterization of the Expression in Liver and Catalytic Activity of CYP2B6

Sean Ekins; Mark Vandenbranden; Barbara J. Ring; Jennifer S. Gillespie; Tian J. Yang; Harry V. Gelboin; Steven A. Wrighton

Journal of Pharmacology and Experimental Therapeutics | 1999

Three- and Four-Dimensional Quantitative Structure Activity Relationship Analyses of Cytochrome P-450 3A4 Inhibitors

Sean Ekins; Shelly N. Binkley; Jennifer S. Gillespie; Barbara J. Ring; James H. Wikel; Steven A. Wrighton

Drug Metabolism and Disposition | 2002

Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism

Barbara J. Ring; Jennifer S. Gillespie; James A. Eckstein; Steven A. Wrighton

Drug Metabolism and Disposition | 2000

Three- and Four-Dimensional-Quantitative Structure Activity Relationship (3D/4D-QSAR) Analyses of CYP2C9 Inhibitors

Sean Ekins; Shelly N. Binkley; Jennifer S. Gillespie; Barbara J. Ring; James H. Wikel; Steven A. Wrighton

Journal of Pharmacology and Experimental Therapeutics | 1999

Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6.

Sean Ekins; Barbara J. Ring; Todd A. Gillespie; Jennifer S. Gillespie; Mark Vandenbranden; Steven A. Wrighton; James H. Wikel

Pharmacogenetics | 1999

Three and four dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2D6 inhibitors.

Sean Ekins; Shelly N. Binkley; Jennifer S. Gillespie; Barbara J. Ring; James H. Wikel; Steven A. Wrighton

Journal of Pharmacology and Experimental Therapeutics | 2001

Identification of the Human Cytochromes P450 Responsible for in Vitro Formation of R- and S-Norfluoxetine

Barbara J. Ring; James A. Eckstein; Jennifer S. Gillespie; Shelly N. Binkley; Mark Vandenbranden; Steven A. Wrighton

Journal of Pharmacology and Experimental Therapeutics | 2003

Atomoxetine Hydrochloride: Clinical Drug-Drug Interaction Prediction and Outcome

John-Michael Sauer; Amanda J. Long; Barbara J. Ring; Jennifer S. Gillespie; Nathan P. Sanburn; Karl A. DeSante; David M. Petullo; Mark Vandenbranden; Charles B. Jensen; Steven A. Wrighton; Brian P. Smith; Holly A. Read; Jennifer Witcher

Drug Metabolism and Disposition | 1998

Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices

Mark Vandenbranden; Steven A. Wrighton; Sean Ekins; Jennifer S. Gillespie; Shelly N. Binkley; Barbara J. Ring; Gadberry Mg; Mullins Dc; Stephen C. Strom; Jensen Cb

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