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Joan M. Caroon

Hoffmann-La Roche

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Publication

Featured researches published by Joan M. Caroon.

Bioorganic & Medicinal Chemistry Letters | 1995

N,N-6-bis-[2-(3,4-dihydroxybenzyl)pyrrolidinyl]hexane, a potent, selective, orally active dopamine analog with hypotensive and diuretic activity☆

Lawrence E. Fisher; Roberto P. Rosenkranz; Robin D. Clark; Joseph M. Muchowski; Deborah L. McClelland; Anton D. Michel; Joan M. Caroon; Edvige Galeazzi; Richard M. Eglen; Roger L. Whiting

Abstract The D-1 and D-2 affinities, in vivo femoral and renal vasodilatory effects, oral antihypertensive and diuretic effects and syntheses of selected dopamine congeners are described.

Journal of Medicinal Chemistry | 1983

Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones

Robin D. Clark; Joan M. Caroon; Arthur F. Kluge; David Bruce Repke; Adolph P. Roszkowski; Arthur M. Strosberg; Stephen J. Baker; Susan M. Bitter; Marlys D. Okada

Journal of Organic Chemistry | 1993

O-Methylarenehydroxamates as ortho-lithiation directing groups. Titanium(III)-mediated conversion of O-methyl hydroxamates to primary amides

Lawrence E. Fisher; Joan M. Caroon; Jahangir; S. Russell Stabler; Scott Lundberg; Joseph M. Muchowski

Journal of Medicinal Chemistry | 1981

Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4.5]decan-2-ones.

Joan M. Caroon; Robin Douglas Clark; Arthur F. Kluge; Janis T. Nelson; Arthur M. Strosberg; Stefan H. Unger; Anton D. Michel; Roger L. Whiting

Archive | 2004

Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs

Richard Schumacher; Allen Hopper; Robert Dunn; Erik Kuester; Ashok Tehim; Thomas E. Renau; Joan M. Caroon; Francisco Xavier Talamas; Sharada Shenvie Labadie

Journal of Medicinal Chemistry | 1982

Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists.

Joan M. Caroon; Robin Douglas Clark; Arthur F. Kluge; Ronald Olah; David Bruce Repke; Stefan H. Unger; Anton D. Michel; Roger L. Whiting

Journal of Medicinal Chemistry | 1983

Synthesis and antihypertensive activity of a series of spiro[1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizine-2,5'-oxazolidin-2'-one]s.

Joan M. Caroon; Robin D. Clark; Arthur F. Kluge; Chi-Ho Lee; Arthur M. Strosberg

Canadian Journal of Chemistry | 1994

Mild hydrolysis or alcoholysis of amides. Ti(IV) catalyzed conversion of primary carboxamides to carboxylic acids or esters

Lawrence E. Fisher; Joan M. Caroon; S. Russell Stabler; Scott Lundberg; Shahid Zaidi; Carole M. Sorensen; Mark L. Sparacino; Joseph M. Muchowski

Archive | 2006

Trisubstituted amines as phosphodiesterase 4 inhibitors

Francisco Xavier Talamas; Joan M. Caroon; Robert Dunn; Allen Hopper; Eric Kuester; Richard Schumacher; Ashok Tehim

Archive | 1999

2-arylethyl-(piperidin-4-ylmethyl)amine derivatives

Joan M. Caroon; Robin D. Clark; Michael Patrick Dillon; Ralph New Harris; Sharathchandra Surendra Hegde; Clara Jeou Jen Lin; Hans Maag; David B. Repke

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Robin D. Clark

University of California

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David Bruce Repke

Hoffmann-La Roche

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Anton D. Michel

University of Hertfordshire

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Stefan H. Unger

Pomona College

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Lawrence E. Fisher

Hoffmann-La Roche

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Robin Douglas Clark

Hoffmann-La Roche

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Clara Jeou Jen Lin

Hoffmann-La Roche

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Dov Nitzan

Hoffmann-La Roche

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Francisco Javier Lopez-Tapia

Hoffmann-La Roche

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Francisco Xavier Talamas

Hoffmann-La Roche

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