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Lawrence E. Fisher

Hoffmann-La Roche

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Publication

Featured researches published by Lawrence E. Fisher.

Bioorganic & Medicinal Chemistry Letters | 1995

N,N-6-bis-[2-(3,4-dihydroxybenzyl)pyrrolidinyl]hexane, a potent, selective, orally active dopamine analog with hypotensive and diuretic activity☆

Lawrence E. Fisher; Roberto P. Rosenkranz; Robin D. Clark; Joseph M. Muchowski; Deborah L. McClelland; Anton D. Michel; Joan M. Caroon; Edvige Galeazzi; Richard M. Eglen; Roger L. Whiting

Abstract The D-1 and D-2 affinities, in vivo femoral and renal vasodilatory effects, oral antihypertensive and diuretic effects and syntheses of selected dopamine congeners are described.

Drugs in R & D | 1999

Matrix metalloprotease inhibitors

Steven Lee Bender; Chris Allen Broka; Jeffrey Allen Campbell; Arlindo L. Castelhano; Lawrence E. Fisher; Robert Than Hendricks; Keshab Sarma

Journal of Medicinal Chemistry | 1990

1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor.

Robin D. Clark; Klaus K. Weinhardt; Jacob Berger; Lawrence E. Fisher; Christine M. Brown; Alison C. MacKinnon; Andrew T. Kilpatrick; Michael Spedding

Archive | 2002

New indole derivatives with 5-HT6 receptor affinity

Colin Charles Beard; Robin Douglas Clark; Lawrence E. Fisher; Ralph New Harris; David Bruce Repke

Journal of Organic Chemistry | 1992

Heteroatom-directed metalation. Lithiation of N-propenylbenzamides and N-propenyl-o-toluamides. Novel routes to ortho-substituted primary benzamide derivatives and N-unsubstituted isoquinolin-1(2H)-ones

Lawrence E. Fisher; Joseph M. Muchowski; Robin D. Clark

Journal of Organic Chemistry | 1993

O-Methylarenehydroxamates as ortho-lithiation directing groups. Titanium(III)-mediated conversion of O-methyl hydroxamates to primary amides

Lawrence E. Fisher; Joan M. Caroon; Jahangir; S. Russell Stabler; Scott Lundberg; Joseph M. Muchowski

Synthesis | 1991

Preparation of Indoles and Oxindoles from N-(tert-Butoxycarbonyl)-2-alkylanilines

Robin D. Clark; Joseph M. Muchowski; Lawrence E. Fisher; Lee A. Flippin; David B. Repke; Michel Souchet

Archive | 2000

Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative

Charles Alois Dvorak; Douglas L. Wren; Lawrence E. Fisher; Steven D. Axt; Eric R. Humphreys; Humberto Bartolome Arzeno; Colin Charles Beard; Sam Linh Nguyen; Yeun-Kwei Han; Christopher R. Roberts; Jan P. Lund; Paul R. Fatheree

Organic Preparations and Procedures International | 1990

SYNTHESIS OF α-AMINOALDEHYDES AND α-AMINOKETONES. A REVIEW

Lawrence E. Fisher; Joseph M. Muchowski

Canadian Journal of Chemistry | 1994

Mild hydrolysis or alcoholysis of amides. Ti(IV) catalyzed conversion of primary carboxamides to carboxylic acids or esters

Lawrence E. Fisher; Joan M. Caroon; S. Russell Stabler; Scott Lundberg; Shahid Zaidi; Carole M. Sorensen; Mark L. Sparacino; Joseph M. Muchowski

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Joseph M. Muchowski

Stanford University

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Charles Alois Dvorak

Hoffmann-La Roche

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Anthony Prince

Hoffmann-La Roche

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Jeffrey Allen Campbell

Hoffmann-La Roche

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Ralph New Harris

Hoffmann-La Roche

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Hans Maag

Hoffmann-La Roche

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Keena Lynn Green

Hoffmann-La Roche

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Alam Jahangir

Hoffmann-La Roche

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Colin Charles Beard

Hoffmann-La Roche

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Joan M. Caroon

Hoffmann-La Roche

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