John Robert Rizzo | Researchain

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Featured researches published by John Robert Rizzo.

Tetrahedron | 2000

Enantioselective Syntheses of 1-Carbacephalosporins from Chemoenzymically Derived β-Hydroxy-α-Amino Acids: Applications to the Total Synthesis of Carbacephem Antibiotic Loracarbef

Billy Grinnell Jackson; Steve W Pedersen; Jack W. Fisher; Jerry Wayne Misner; John P. Gardner; Michael A. Staszak; Christopher W. Doecke; John Robert Rizzo; James Abraham Aikins; Eugene Farkas; Kristina L Trinkle; Jeffrey T. Vicenzi; Matt R. Reinhard; Eugene Paul Kroeff; Chris A Higginbotham; Robert James Gazak; Tony Y. Zhang

Abstract Serine hydroxymethyltransferase (SHMT) derived from recombinant E. coli was found to be able to catalyze the condensation between glycine and 4-pentenaldehyde, affording enantiopure l -erythro-2-amino-3-hydroxy-6-heptenoic acid (AHHA) in high yield and throughput. Conversion of this chiral intermediate of biosynthetic origin to the oral carbacephalosporin antibiotic loracarbef (Lorabid®) via β-lactam forming reactions and subsequent Dieckmann cyclization was achieved.

Archive | 2009

Inhibitors of diacylglycerol acyltransferase

Macklin Brian Arnold; Thomas James Beauchamp; Emily J. Canada; Erik James Hembre; Jianliang Lu; John Robert Rizzo; John Mehnert Schaus; Qing Shi

Archive | 1997

Non-peptidyl vasopressin V1a antagonists

Robert F. Bruns; Robin D. G. Cooper; Bruce A. Dressman; David C. Hunden; Stephen W. Kaldor; Gary A. Koppel; John Robert Rizzo; Jeffrey J. Skelton; Mitchell I. Steinberg

Bioorganic & Medicinal Chemistry Letters | 2005

2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.

Jose Alfredo Martin; Dawn A. Brooks; Lourdes Prieto; Rosario Gonzalez; Alicia Torrado; Isabel Rojo; Beatrriz Lopez De Uralde; Carlos Lamas; Rafael Ferritto; María Martín-Ortega; Javier Agejas; Francisco Parra; John Robert Rizzo; Gary A. Rhodes; Roger L. Robey; Charles A. Alt; Samuel R. Wendel; Tony Y. Zhang; Anne Reifel-Miller; Chahrzad Montrose-Rafizadeh; Joseph T. Brozinick; Eric Hawkins; Elizabeth A. Misener; Daniel A. Briere; Robert Ardecky; James D. Fraser; Alan M. Warshawsky

Tetrahedron Letters | 2008

An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones

John Robert Rizzo; Charles A. Alt; Tony Y. Zhang

Archive | 2000

Preparation of substituted piperidin-4-ones

John Robert Rizzo; Michael A. Staszak; Tony Y. Zhang

Archive | 2000

Compounds useful as neuro-protective agents

Jill Ann Panetta; John Kevin Shadle; Lawrence Joseph Heinz; Michael Leroy Phillips; John Robert Rizzo; Benjamin Alan Anderson; John Allan Rieck; David L. Varie

Archive | 1997