Lawrence Joseph Heinz
Eli Lilly and Company
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Publication
Featured researches published by Lawrence Joseph Heinz.
Bioorganic & Medicinal Chemistry Letters | 1996
Celia A. Whitesitt; Richard Lee Simon; Jon K. Reel; Sandra Kay Sigmund; Michael Leroy Phillips; J. Kevin Shadle; Lawrence Joseph Heinz; Gary A. Koppel; David C. Hunden; Sherryl Lynn Lifer; Dennis R. Berry; Judy Ray; Sheila P. Little; Xiadong Liu; Winston S. Marshall; Jill Ann Panetta
Abstract Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in many disease states including Alzheimers disease, were prepared and evaluated. The most potent inhibitor of cathepsin D in this series was found to be (Z)-5-[[4-(4-benzoyl-3-hydroxy-2-propylphenoxy) methylphenyl]methylene]-2-thioxo-4-thiazolidinone ( 3f , IC 50 = 210 nM).
Bioorganic & Medicinal Chemistry Letters | 1998
Paul L. Ornstein; M. Brian Arnold; William Henry Walker Lunn; Lawrence Joseph Heinz; J. David Leander; David Lodge; Darryle D. Schoepp
We report the synthesis and characterization of compounds that are competitive NMDA receptor antagonists. Significant increases in affinity and potency were obtained by incorporation of a heteroatom into the substructure of the tetrazole-substituted amino acid LY233053.
Archive | 2003
Jochen Ammenn; James Ronald Gillig; Lawrence Joseph Heinz; Philip Arthur Hipskind; Michael Dean Kinnick; Yen-Shi Lai; John Michael Morin; James Arthur Nixon; Carsten Ott; Kenneth Allen Savin; Theo Schotten; Lawrence J. Slieker; Nancy June Snyder; Michael Alan Robertson
Archive | 1995
Lawrence Joseph Heinz; Jill Ann Panetta; Michael Leroy Phillips; Jon K. Reel; John Kevin Shadle; Richard Lee Simon; Celia A. Whitesitt
Journal of Medicinal Chemistry | 1992
William Henry Walker Lunn; Darryle D. Schoepp; David O. Calligaro; R. T. Vasileff; Lawrence Joseph Heinz; Craig R. Salhoff; Patrick J. O'Malley
Archive | 2002
Sandra Ann Filla; Michael Edward Flaugh; James Ronald Gillig; Lawrence Joseph Heinz; Joseph H. Krushinski; Bin Liu; Marta Maria Pineiro-Nunez; John Mehnert Schaus; John S. Ward
Archive | 1997
Lawrence Joseph Heinz; Jill Ann Panetta; Michael Leroy Phillips; John Kevin Shadle
Journal of Organic Chemistry | 1996
Lawrence Joseph Heinz; William Henry Walker Lunn; R. E. Murff; Jonathan W. Paschal; Larry A. Spangle
Analytical Biochemistry | 2004
Xiaoying Gao; Chiun-King Hsu; Lawrence Joseph Heinz; John Michael Morin; Yuguang Shi; Nikhil K Shukla; David L. Smiley; Jie Xu; Boyu Zhong; Lawrence J. Slieker
Archive | 1997
Lawrence Joseph Heinz; William Henry Walker Lunn; Paul L. Ornstein
