Jun Yamagata

Cytologic Studies of Nipple Discharges

Cytologic findings of nipple discharges from 71 histologically confirmed breast cases (29 malignant and 42 benign) were analyzed. Papillary clusters composed of more than 30 ductal cells were found in the discharges from 18 of the malignant cases (62%) and 6 of the benign cases (14%); all 6 benign cases with papillary clusters were papillomas. Erythrocytes were detected in the discharges from 15 of the malignant cases (52%) and 5 of the benign cases (12%); 4 of the 5 benign cases with bloody discharge were papillomas. Both erythrocytes and papillary clusters were observed in the discharges from 14 of the malignant cases (48%) and 2 of the benign cases (5%).

Morphologic Characteristics of Mammary Carci noma Cells

Cytologic findings of mammary carcinoma of histologictypes were analyzed in this paper. In the cytologic study, 20 cases with medullary carcinoma, 20 cases with papillarycarcinoma and 20 cases with scirrhous carcinomas wereselected from about 200 cases with mammary cancer. Smears were prepared with carcinomatous tissues obtainedfrom these cases by use of excised surgical materials.The smears obtained from medullary carcinoma were themost hypercellular among those three cancer types, and thecells were found tending to remarkably scatter and separatefrom each other. The smears obtained from papillarycarcinomas were characterized by the papillary or tubularcell arrangement in the cluster. The smears obtained fromtypical scirrhous carcinomas were different from those of other two cancer types. The cell size was commonly small, and the cells with picnotic nucleus were often observed inthe smears. The cell clusters were usually composed of less than 50 cells, so the majority of the clusters were smallin size.

Cytologic Studies on Duct Papillomatosis of the Breast with Special Reference to Borderline Lesions

For the review of the results of cytologic evaluation, eighteen cases histologically diagnosed as intraductal papillloma and duct papillomatosis were classified into three groups; cases of typical duct papillomatosis, borderline cases between malignancy and benigncy, and cases with cancer lesions.In typical duct papillomatosis cellular atypism was not so striking either in nipple discharge or aspiration smear.In borderline cases and cases with cancer lesions, some degree of cellular atypism was not infrequently observed; e. g.nuclear enlargement, abnormal nuclear shape and irregular piling of nuclei etc., so the majo rity of such cases were diagnosed cytologically as cancer cell positive, especially in touch smear speci mens of surgical materials.

Cytological studies on mammary fibroadenoma

The cell pattern of fibroadenoma was observed by aspiration and operation smears obtained from 13 cases.All these were diagnosed histologically as fibroadenhma.The preparations were stained by M-G-G method.Usually, each cell from fibroadenoma case was round or oval in shape and small in size.It was rare to find nuclei over 20μ.Regular piling of cells was commonly found in these cases.Sometimes, the smears of fibroadenoma with remarkable epithelial proliferation had abundant cell materials and mild loose cohesion similar to the smears of cancer cases.Large and variable size of nuclei, irregular piling of cells, fusion of cell border and cell inclusion were common observations in cancer cases. But these findings were scarcely observed in fibroadenoma cases.