Junji Yamamoto

Repeat liver resection for recurrent colorectal liver metastases

BACKGROUNDnThis study aimed to delineate the role of surgery for recurrent colorectal cancer in the liver and to identify prognosticators for better patient selection and outcome.nnnMETHODSnData from 90 repeat hepatectomies (second = 75; third = 12; fourth = 3) for recurrent colorectal cancer were collected.nnnRESULTSnAfter the second hepatectomy, the 3-and 5-year survival rates were 48% and 31%, respectively. Twenty-seven percent (20 of 75) of patients are alive without recurrence after a median follow-up of 27 months, and 9 survived more than 5 years. Four or more tumors, positive regional lymph node metastases, concomitant extrahepatic disease, and residual tumor were independent poor prognostic factors after the second hepatectomy.nnnCONCLUSIONSnRepeat hepatectomy should be applied for recurrent colorectal cancer, when curative removal of the tumor is possible, although the benefit from treatment was limited in a patient with regional lymph node metastases, 4 or more metastases, or extrahepatic disease.

Clinicopathological features of recurrent primary liver cancer in Japan

In this chapter, the clinicopathological features of recurrent hepatocellular carcinoma (HCC), especially after hepatectomy, are described along with a review of some articles and the author’s experiences.