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Junya Imai

Kyoto Pharmaceutical University

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Featured researches published by Junya Imai.

Chemical & Pharmaceutical Bulletin | 1992

Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine.

Tsutomu Mimoto; Junya Imai; Sumitsugu Kisanuki; Hiroshi Enomoto; Naoko Hattori; Kenichi Akaji; Yoshiaki Kiso

Chemical & Pharmaceutical Bulletin | 1991

KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic.

Tsutomu Mimoto; Junya Imai; Shigeki Tanaka; Naoko Hattori; Sumitsugu Kisanuki; Kenichi Akaji; Yoshiaki Kiso

Chemical & Pharmaceutical Bulletin | 1991

Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic

Tsutomu Mimoto; Junya Imai; Shigeki Tanaka; Naoko Hattori; Osamu Takahashi; Sumitsugu Kisanuki; Yuichi Nagano; Makoto Shintani; Hideya Hayashi; Hiroshi Sakikawa; Kenichi Akaji; Yoshiaki Kiso

Chemical & Pharmaceutical Bulletin | 2000

Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere

Tsutomu Mimoto; Naoko Hattori; Haruo Takaku; Sumitsugu Kisanuki; Tominaga Fukazawa; Keisuke Terashima; Ryohei Kato; Satoshi Nojima; Satoru Misawa; Takamasa Ueno; Junya Imai; Hiroshi Enomoto; Shigeki Tanaka; Hiroshi Sakikawa; Makoto Shintani; Hideya Hayashi; Yoshiaki Kiso

Chemical & Pharmaceutical Bulletin | 1990

Fluoren-9-ylmethyloxycarbonyl (Fmoc) Amino Acid Chloride as an Efficient Reagent for Anchoring Fmoc Amino Acid to 4-Alkoxybenzyl Alcohol Resin

Kenichi Akaji; Hideo Tanaka; Hisatomi Itoh; Junya Imai; Yoichi Fujiwara; Tooru Kimura; Yoshiaki Kiso

Archive | 1993

Structure-activity relationships of HIV protease inhibitors containing allophenylnorstatine as a transition-state mimic

Sumitsugu Kisanuki; Tsutomu Mimoto; Junya Imai; Hiroshi Enomoto; Naoko Hattori; Osamu Takahashi; Ryohei Katoh; Shigeki Tanaka; Hiroshi Sakikawa; Tooru Kimura; Kenichi Akaji; Yoshiaki Kiso

Archive | 1993

Design of HIV protease inhibitors with effective antiviral activity: Use of allophenylnorstatine as a transition-state mimic

Yoshiaki Kiso; Tsutomu Mimoto; Junya Imai; Sumitsugu Kisanuki; Naoko Hattori; Hiroshi Enomoto; Kenichi Akaji; Seiji Kageyama; Hiroaki Mitsuya

Archive | 1993

Design and activity of protease active site-targeted anti-HIV agents containing allophenylnorstatine

Tsutomu Mimoto; Sumitsugu Kisanuki; Junya Imai; Hiroshi Enomoto; Naoko Hattori; Seiji Kageyama; Hiroaki Mitsuya; Kenichi Akaji; Yoshiaki Kiso

Archive | 1993

Structure-activity relationships of HIV protease inhibitors containing hydroxymethylcarbonyl isostere as a transition state mimic

Tsutomu Mimoto; Junya Imai; Sumitsugu Kisanuki; Naoko Hattori; Osamu Takahashi; Hiroshi Enomoto; Kenichi Akaji; Yoshiaki Kiso

Journal of pharmacobio-dynamics | 1992

Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept

Tsutomu Mimoto; Junya Imai; Sumitsugu Kisanuki; Shigeki Tanaka; Naoko Hattori; Osamu Takahashi; Ryohei Katoh; Takuya Yumisaki; Hiroshi Sakikawa; Kenichi Akaji; Yoshiaki Kiso

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