Jurema Freire Lisboa de Castro

Effect of Low-Level Laser Therapy in the Treatment of Burning Mouth Syndrome: A Case Series

OBJECTIVE The aim of this study was evaluate the effect of low-level laser therapy (LLLT) in the treatment of burning mouth syndrome (BMS) patients. BACKGROUND DATA BMS is a clinical condition characterized by a burning sensation in a morphologically normal oral mucosa, without association with systemic disorders. METHODS Ten patients with oral burning sensation were included in the study. After careful evaluation of medical history and oral examination, the diagnosis of BMS was established. All patients were submitted to one weekly session of LLLT for 10 weeks. A continuous wavelength of 660 nm, power 40 mW, 20 J/cm(2), 0.8 J/point, with each point irradiated for 10 sec. In all sessions the burning intensity was evaluated with a 10-cm visual analogue scale (VAS), with 0 indicating no symptoms and 10 indicating the worst burning possible. The burning intensity evaluation by VAS was performed immediately before (VAS baseline) and immediately after each LLLT session. The nonparametric Wilcoxon test was used for statistical analysis, considering significance of 5%. RESULTS All patients reported improvement in all sessions, with reduction in VAS scores by up to 58% in the tenth session. When only the VAS baseline of the first session was compared with the other sessions, there was a statistically significant reduction in VAS scores in the fourth (p=0.03), fifth (p=0.03), sixth (p=0.009), seventh (p=0.003), eighth, ninth, and tenth (all p=0.002) sessions. CONCLUSIONS LLLT may be an alternative treatment for the relief of oral burning in patients with BMS.

Ação da laserterapia no processo de proliferação e diferenciação celular: revisão da literatura

Low energy laser has been used as an adjuvant therapy or as a therapeutic tool in many different areas of Dentistry. It is recognized by its anti-inflammatory and analgesic properties, and also as a tissue repair inductor. Low intensity laser property in stimulate cell proliferation during wound healing and its biomodulation mechanisms are discussed in this paper. These properties have already been established for cultured benign cells, but there is a controversy when extended to the spectrum of the malignant neoplastic process, normally generating great discussions. The objective of this work was to perform a literature review about the low intensity laser capacity in induce cell proliferation. The discussion is specially concerned about its effects on malignant cells.

Abnormal transcranial magnetic stimulation in a patient with presumed psychogenic paralysis

Conversion disorders (CD) are frequently related to the locomotor system (paresis, abnormal movements) but also to the somatosensory system (positive and negative symptoms) or visual system (tunnel vision, blindness).1 2 CD is classified within the group of “somatoform disorders” in the Diagnostic and Statistical Manual of Mental Disorders-IV and its definition implies that the patient has no voluntary control over the production of symptoms (unlike factitious disorder or malingering). The reported rate of misdiagnosis of conversion symptoms has, on average, been 4% since 1970.1 Psychogenic paralysis (PP) is generally a diagnostic challenge for the neurologist, usually leading to an expensive work-up to exclude organic lesions. There are several theories explaining CD. There are, however, few methods that are able to highlight the mechanisms underlying this disorder.1 2 Some reports suggest that functional brain imaging3 and neurophysiological studies may prove to be a useful approach. We report a case of PP where changes in transcranial magnetic stimulation (TMS) were found. A 25-year-old married healthy woman was referred to the neurology department with a 3 …

Solitary peripheral osteomas of the jaws

Osteoma is a benign osteogenic tumor composed of cancellous or compact bone, classified as peripheral, central, or extraskeletal. Peripheral osteomas are uncommon. Excluding the maxillary sinuses, the maxilla is a rare site for osteomas. The purpose of this report was to describe clinicopathological and radiological features of two peripheral osteomas occurring in the jaws, one located in the mandible and another in the edentulous maxillary alveolar ridge. The tumors were asymptomatic and were fully excised without any complications or recurrence. The lesions were submitted to histopathological analysis and diagnosed as peripheral osteoma, compact type.

Head and neck solitary infantile myofibroma: Clinicopathological and immunohistochemical features of a case series

Infantile myofibroma is a rare mesenchymal benign tumor mostly found in the head and neck region. The aim of this study was to describe a small case series of head and neck solitary infantile myofibroma, emphasizing the importance of the histopathological and immunohistochemical features, and the potential diagnostic challenges. For the study, clinical and imaging data were obtained from the medical records. All cases were histologically reviewed, and immunohistochemical analyses were performed to confirm the diagnosis. Four cases of head and neck solitary infantile myofibroma were identified. All patients were females and presented a mean age of 3 years old (ranging from 2 to 6 years). The site of the tumors were the mandible, right cheek, subcutaneous tissue adjacent to basal cortical of the mandible and upper anterior gingiva. No symptoms, such as pain or paresthesia, were reported. Computerized tomography revealed well-delimited tumors. All tumors were positive for vimentin and alpha-smooth muscle actin. All patients underwent surgical excision and no signs of recurrence were observed after long-term follow-up. In summary, head and neck solitary infantile myofibromas are rare and present excellent prognosis. The correlation between clinical, histopathological and immunohistochemical features are essential for a correct diagnosis.

Prevalência das anomalias dentárias em pacientes submetidos a tratamento ortodôntico

O presente estudo teve como objetivo avaliar a prevalencia das disgenesias dentarias em pacientes submetidos a tratamento ortodontico na cidade do Recife, no periodo de 1991 a 1999, por meio da observacao de dados contidos em prontuarios e do exame radiografico. Foram examinados 551 prontuarios, dos quais 124 (22,5%) apresentaram essas alteracoes.Os resultados demonstraram que 44 (7,99%) das disgenesias estavam presentes no genero masculino e que dois pacientes deste grupo apresentaram mais de um tipo das mesmas. Outras 80 (14,52%) pertenciam ao genero feminino, sendo que 3 pacientes deste grupo apresentaram tambem mais de uma alteracao; dessa forma ocorreram 130 disgenesias. A hipodontia foi a mais prevalente com (86,92%). As disgenesias diagnosticadas nao mostraram diferencas de ocorrencias entre os generos e localizacao nos arcos superior e inferior. O presente estudo mostra a importância da observacao radiografica para deteccao de disgenesias e elaboracao de um plano de tratamento baseado na ocorrencia delas.

Evaluation of viral load in saliva from patients with chronic hepatitis C infection

Hepatitis C virus can be detected in blood and other bodily fluids, such as saliva. The aim of this study was to detect and quantify the HCV-RNA in saliva and plasma from patients with chronic hepatitis C infections, as well as check the level of viral load in sex groups (age, ethnicity and virus subtypes). Whole saliva and blood from 70 patients with chronic hepatitis C infections attended at the department of gastroenterology from University Hospital. The HCV-RNA load was performed by qRT-PCR using Sybr Green I master mix. HCV-RNA was detected in 80% (56/70) of patients in saliva and 92.85% (65/70) in plasma. The median of the viral load in the plasma was of 4.87 log10, and in saliva, it was 3.32log10, (p = 0.0005). Female patients and black patients exhibited a negative correlation between the HCV-RNA load in saliva vs. the HCV-RNA load in plasma (r = -0.3172, CI95% -0.6240 to -0.03736, p = 0.0491) and (r = -0.3141; IC95% -0.6069 to -0.05926; p = 0.0209), respectively. HCV-RNA was detected and quantified in saliva samples, and according to the quantification levels, saliva may be a possible transmission source of HCV, particularly in women and people of black ethnicity who develop chronic HCV infections.

Análise Morfológica da Mucosa Oral de Ratos Submetida à Carcinogênese Experimental pelo Óxido de Nitroquinolina (4NQO)

Resumen pt: Objetivo: Induzir a carcinogenese na mucosa lingual de ratos Wistar atraves do oxido de nitroquinolina (4NQO), relacionando as alteracoes clinicas e micr...

Pigmented Oral Squamous Cell Carcinoma: A Case Report and Brief Review of the Literature

Melanin impregnation in squamous cell carcinoma (SCC) is an uncommon histological finding. Rare nonmelanocytic entities were previously described as having melanocyte colonization. A 57-year-old Brazilian woman was referred with a pigmented lesion in the lower lip and alveolar ridge with a prior clinical diagnosis of melanoma. The incisional biopsy of the tumor revealed an SCC with strong colonization of melanocytes in the stroma. The authors report a case of an unusual SCC variant and a brief review of the literature.

Oral squamous cell carcinoma: a clinicopathological study on 194 cases in northeastern Brazil. A cross-sectional retrospective study

BACKGROUND Only a few studies have evaluated the clinicopathological features of oral squamous cell carcinoma (SCC) in Brazil, and most were conducted in the most industrialized region of the country, i.e. the southeastern region. The aim of this study was to evaluate the clinicopathological features of this malignant neoplasm in northeastern Brazil. DESIGN AND SETTING Retrospective study performed in an oral pathology laboratory in Recife, Brazil. METHODS All cases of oral SCC that occurred between 2000 and 2015 were studied. Clinical data were recorded and histological slides were reviewed. Statistical analysis was performed using the chi-square test (P ≤ 0.05). RESULTS A total of 194 cases were evaluated. The male-to-female ratio was 1.5:1. The mean age was 65.4 years, and only 6.6% of the cases occurred in patients younger than 41 years. Most tumors consisted of well-differentiated SCC (54.6%). CONCLUSIONS The findings of this study highlight the higher prevalence of oral SCC among women and the increasing number of cases among young patients. Thus there is no specific risk group for oral SCC, as in the past. This fact needs to be taken into consideration in clinical routine care, so that apparently innocuous malignant lesions do not go unnoticed in these individuals.