Kamran J. Naquvi

Two new aliphatic lactones from the fruits of Coriandrum sativum L.

Background The present paper describes the isolation and characterization of two new aliphatic δ-lactones along with three glycerides and n-nonadecanyl cetoleate from the fruits of Coriandrum sativum L. (Apiaceae). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical reactions. Results Phytochemical investigation of the methanolic extract of C. sativum L. (Apiaceae) fruits resulted in the isolation of two new aliphatic δ-lactones characterized as 2α-n-heptatriacont-(Z)-3-en-1,5-olide (1) (coriander lactone) and 2α-n-tetracont-(Z,Z)-3,26-dien-18α-ol-1,5-olide (2) (hydroxy coriander lactone) together with glyceryl-1,2-dioctadec-9,12-dienoate-3-octadec-9-enoate (3); glyceryl-1,2,3-trioctadecanoate (4); n-nonadecanyl-n-docos-11-enoate (5) and oleiyl glucoside (6). Conclusions Phytochemical investigation of the methanolic extract of C. sativum gave coriander lactone and hydroxy coriander lactone as the new phytoconstituents.

PHYSICO-CHEMICAL AND PHYTOCHEMICAL EVALUATION OF CARICA PAPAYA LINN. UNRIPE FRUITS

Present study was performed for the development of quality standards of Carica papaya Linn. commonly known as Papita belonging to family Caricaceae is well known for its exceptional nutritional and medicinal properties. The study comprises of physico-chemical and phytochemical evaluation to confirm purity and authenticity of Carica papaya L. unripe fruit using WHO guidelines. Microscopy of the fruit showed presence thick cuticle, parenchyma, epicarp, mesocarp endocarp, calcium oxalate crystals, laticifers, etc. Successive extractive value and hot extractive value was found highest in alcoholic extract 48.34 % and 44.90 % respectively (on dry weight basis). Mean ash values (%) are 8.63 (total), 0.79 (acid insoluble ash), and 5.30 (water soluble ash) and moisture content was found to be 9.41 % and the phytochemical analysis revealed the presence of carbohydrates, terpenoids, flavonoids, phenolic compounds in different extracts of Carica papaya L. fruit. TLC fingerprinting profile of different extracts were also developed and quantification of β-carotene was also done by using nhexane:acetone (8.5:1.5) as a mobile phase at 415 nm and found to be higher in pet ether Carica papaya L. fruit extract 1.55 % w/w.

ISOFLAVONE GLYCOSIDES FROM AERIAL PARTS OF Artemisia absinthium

Two new isoflavone glycosides, designated as artemisia bis-isoflavonyl dirhamnoside and artemisia isoflavonyl glucosyl diester, have been isolated from the aerial parts of A. absinthium and their structures established as 7a,7b-bis-[(5a-hydroxy-3′a,4′a-dimethoxyisoflavonyl) (5b,4′b-dihydroxy-3′b-methoxyisoflavonyl)]-4′b-α-Drhamnopyranosyl-(4 → 1)-α-D-rhamnopyranoside and 7,4′-dihydroxyisoflavonyl-7-β-D-glucopyranosyl-(2 → 1)-β-D-glucopyranosyl-(2 → 1)-β-D-glucopyranosyl-(2 → 1)-β-D-glucopyranosyl-6d-(octadec-9′″-enoate)-2d-7″,11″,15″-trimethylpentadecan-3″,15″-dioic acid-1″-oate on the basis of chemical reactions and spectral data analysis.