Katsuya Kuwata

Inhibitory Effect of (—)‐Epigallocatechin Gallate on Carcinogenesis with N‐Ethyl‐N′‐nitro‐N‐nitrosoguanidine in Mouse Duodenum

(—)‐Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two‐stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N‐ethyl‐N′‐nitro‐N‐nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.

Inhibitory Effect of Green Tea Extract Against Azoxymethane-Induced Colon Carcinogenesis in Rat

We investigated the effect of green tea polyphenol (GTP) on azoxymethane(AOM)-induced colon carcinogenesis in male Fisher rats. AOM was given (7.4mg/kg body weight) s.c. once a week for ten weeks. A week after the treatment, they were divided into three groups. AOM-GTP1 and AOM-GTP2 groups received 0.01 and 0.1% GTP in drinking water respectively from weeks 11 to 26. The AOM-control group received tap water. The tumor incidence in the AOM-GTP1 and AOM-GTP2 groups was significandy lower than that of the AOM-control group. We concluded that GTP supprssed AOM-induced colon carcinogenesis.

Adrenal myelolipoma discovered incidentally on abdominal CT and MR imaging

SummaryThis report describes an adrenal myelolipoma occurring in a 39-year-old man first noted incidentally by computed tomography (CT). The radiographic findings of this neoplasm are briefly discussed and magnetic resonance (MR) imaging of myelolipoma is also described. Myelolipomas can be distinguished from nonfunctioning adenomas by differences in signal intensity on T2-weighted images.