Kazuyuki Kamata

1-(2-Oxazolinyl) indoles

Utilization of 1-(2-oxazolinyl) indoles, prepared from 1-cyano compounds, to the synthesis of 2-substituted indoles was investigated

Synthesis via oxazolines. A highly stereoselective synthesis of (±)-cis-2-methyl cyclopentanecarboxylic acid, via a kinetically controlled cyclization

A kinetically controlled cyclization using the lithio-salt of an oxazoline and 1,4-di-iodopentane gave cis- and trans-2-methyl cyclopentanecarboxylic acid in the ratio 9 : 1.

Rearrangement of 2-(arylmethoxy)methyl-2-oxazolines via lithium azaenolates: a facile synthetic route of ortho-methylmandelic acid derivatives

2-(Arylmethoxy)methyl-2-oxazolines, on treatment with LDA in THF at low temperature, rearrange to afford products which are hydrolysed to ortho-methylmandelic acids or α-(1-methyl-2-naphthyl)glycolic acid.

Synthesis and reaction of N-methyl-N-tosylpyrrolidinium perchlorate, a selective tosylating reagent

Reaction of N-methylpyrrolidine and tosyl chloride in the presence of AgClO4 afforded N-methyl-N-tosylpyrrolidinium perchlorate (II) as a stable, crystalline salt, which can be used for the selective tosylation of an amino-group in the presence of a hydroxy-group.