Kenji Nakaya | Researchain

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Featured researches published by Kenji Nakaya.

Bioorganic & Medicinal Chemistry | 1999

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): a potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist.

Kazumi Kondo; Hidenori Ogawa; Hiroshi Yamashita; Hisashi Miyamoto; Michinori Tanaka; Kenji Nakaya; Kazuyoshi Kitano; Yoshitaka Yamamura; Shigeki Nakamura; Toshiyuki Onogawa; Toyoki Mori; Michiaki Tominaga

We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent.

Journal of Medicinal Chemistry | 1996

Orally Active, Nonpeptide Vasopressin V2 Receptor Antagonists: A Novel Series of 1-[4-(Benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and Related Compounds

Hidenori Ogawa; Hiroshi Yamashita; Kazumi Kondo; Yoshitaka Yamamura; Hisashi Miyamoto; Keizo Kan; Kazuyoshi Kitano; Michinori Tanaka; Kenji Nakaya; Shigeki Nakamura; Toyoki Mori; Michiaki Tominaga; Youichi Yabuuchi

Archive | 1992

Benzazepin derivatives as vasopressin antagonists

Hidenori Ogawa; Kazumi Kondo; Hiroshi Yamashita; Kenji Nakaya; Hajime Komatsu; Michinori Tanaka; Kazuyoshi Kitano; Michiaki Tominaga; Yoichi Yabuuchi

Journal of Medicinal Chemistry | 1993

Orally active, nonpeptide vasopressin V1 antagonists. A novel series of 1-(1-substituted 4-piperidyl)-3,4-dihdyro-2(1H)-quinolinone.

Hidenori Ogawa; Yoshitaka Yamamura; Hisashi Miyamoto; Kazumi Kondo; Hiroshi Yamashita; Kenji Nakaya; Tomihiko Chihara; Toyoki Mori; Michiaki Tominaga; Youichi Yabuuchi

Archive | 1993

Vasopressin antagonist and oxytocin antagonist

Hidenori Axa Nakase Nishinokoshi Ogawa; Kazumi Aza Inamoto Kondo; Hiroshi Yamashita; Kenji Nakaya; Hajime Komatsu; Michinori Tanaka; Kazuyoshi Nishiyamada Hinoki Kitano; Michiaki Tominaga; Yoichi Yabuuchi

Archive | 1991

Vasopressin antagonistic agent

Hajime Komatsu; Kazumi Kondo; Hisashi Miyamoto; Kenji Nakaya; Hidenori Ogawa; Shinya Takara; Michinori Tanaka; Michiaki Tominaga; Yoichi Yabuuchi; Hiroshi Yamashita

Archive | 1997

Thiazole derivative as protein kinase c inhibitors

Toyoki Mori; Michiaki Tominaga; Fujio Tabusa; Kazuyoshi Nagami; Kaoru Abe; Kenji Nakaya; Isao Takemura; Tomoichi Shinohara; Yoshihisa Tanada; Takahito Yamauchi

Archive | 1993

Benzoheterocyclic compounds and vasopressin antagonist and oxytocin antagonist compositions containing a benzoheterocyclic compound

Hidenori Ogawa; Kazumi Kondo; Hiroshi Yamashita; Kenji Nakaya; Hajime Komatsu; Michinori Tanaka; Kazuyoshi Kitano; Michiaki Tominaga; Yoichi Yabuuchi

Archive | 1991

Carbostyryl derivative and vasopressin antagonistic agent

Takafumi Fujioka; Kazuyoshi Kitano; Hajime Komatsu; Kazumi Kondo; Hisashi Miyamoto; Kenji Nakaya; Hidenori Ogawa; Michinori Tanaka; Shuji Teramoto; Michiaki Tominaga; Yoichi Yabuuchi; Hiroshi Yamashita; 賢治中矢; 和良北野; 寿宮本; 道明富永; 修二寺本; 英則小川; 一小松; 博司山下; 理紀田中; 洋一薮内; 孝文藤岡; 一見近藤

Archive | 1997

Thiazole derivate als protein kinase c inhibitoren Thiazoles derivatives as protein kinase inhibitors c

Toyoki Mori; Michiaki Tominaga; Fujio Tabusa; Kazuyoshi Nagami; Kaoru Abe; Kenji Nakaya; Isao Takemura; Tomoichi Shinohara; Yoshihisa Tanada; Takahito Yamauchi

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