Keriann Little

The longitudinal prediction of alcohol consumption-related harms among young adults

This study explores the longitudinal pathways by which risk and protective factors influence the development of alcohol-related harms in a representative community sample of 941 young adults (19–20 years) from Victoria, Australia, focusing on the role of concurrent risky drinking. Impulsivity at 15–16 years, alcohol-related harms at 15–16 years and 17–18 years, frequency of intoxication at 17–18 years, and antisocial behavior, friends’ drinking and living arrangements at 19–20 years were directly related to alcohol-related harms, as well as indirectly related to harms through increased risky drinking. Paternal drinking at 17–18 years was directly related to alcohol-related harms. Friends’ drinking at 19–20 years and alcohol-related harms at age 17–18 interacted with risky drinking to increase the likelihood of alcohol-related harms. Implications for intervention efforts are discussed.

Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study

The extent to which brain structural abnormalities might serve as neurobiological endophenotypes that mediate the link between the variation in the promoter of the serotonin transporter gene (5-HTTLPR) and depression is currently unknown. We therefore investigated whether variation in hippocampus, amygdala, orbitofrontal cortex (OFC) and anterior cingulate cortex volumes at age 12 years mediated a putative association between 5-HTTLPR genotype and first onset of major depressive disorder (MDD) between age 13–19 years, in a longitudinal study of 174 adolescents (48% males). Increasing copies of S-alleles were found to predict smaller left hippocampal volume, which in turn was associated with increased risk of experiencing a first onset of MDD. Increasing copies of S-alleles also predicted both smaller left and right medial OFC volumes, although neither left nor right medial OFC volumes were prospectively associated with a first episode of MDD during adolescence. The findings therefore suggest that structural abnormalities in the left hippocampus may be present prior to the onset of depression during adolescence and may be partly responsible for an indirect association between 5-HTTLPR genotype and depressive illness. 5-HTTLPR genotype may also impact upon other regions of the brain, such as the OFC, but structural differences in these regions in early adolescence may not necessarily alter the risk for onset of depression during later adolescence.

Psychosocial profiles of adolescents from dissolved families: Differences in depressive symptoms in emerging adulthood

BACKGROUND When parents separate, on average, children are at greater risk for concurrent and subsequent depression; however, mean outcomes mask substantial variation in depressive risk. This study aimed to (1) identify multivariate risk profiles (classes) in adolescents from separated families and (2) prospectively estimate class risk for depressive symptoms in emerging adulthood. METHODS The sample comprised 449 participants with separated parents from an Australian population based longitudinal cohort study established in 1983. Classes were explored using 17, theoretically germane, self- and parent-reported indicators of adolescent risk assessed at three points in adolescence (13-14, 15-16 and 17-18 years), spanning three domains of assessment: individual, relational, contextual. Distinct profiles of adolescents were identified using Latent Class Analysis. Class differences on depressive symptoms in emerging adult (19-20 years) were then examined. RESULTS Three multivariate profiles, differentiated by patterns of risk severity, were observed: Adjusted (n = 253), Moderate Risk (n = 156), and High Risk (n = 40). Compared to the Adjusted class, participants in the Moderate Risk, but not High Risk class had notably elevated depressive symptomatology in emerging adulthood (d = 0.35). In contrast, High Risk class membership in adolescence predicted antisocial behavior in emerging adulthood. LIMITATIONS Risk for depressive symptoms in emerging adulthood may be under-estimated due to a disproportionate loss of participants from low socio-economic backgrounds. CONCLUSIONS We found most adolescents from dissolved families to be well-adjusted. Differences between Moderate Risk and High Risk adolescents signal differentiated pathways to subsequent mental health problems. Our findings are relevant for targeted therapeutic strategies for adolescents from dissolved families.