Kotaro Sugiyama

Respiratory involvement in polychlorinated biphenyls poisoning

Abstract Clinical, laboratory, and pathological findings on respiratory involvement in polychlorinated biphenyl (PCB) poisoning were studied in 401 patients and their pathological changes were produced in rats given PCBs orally. Respiratory symptoms included expectoration in 40% of the 289 nonsmoking patients with PCB poisoning and mild wheezing in 2%. The incidence and severity of the respiratory symptoms correlated well with the concentration of PCBs in the blood and sputa. Chest roentgenographic findings, pulmonary function tests, and pathological findings revealed bronchiolitis in many, and pneumonia or atelectasis in about one-tenth of the patients with reticulo-linear shadows. Peribronchiolar changes may be primarily due to either PCB poisoning or associated infection. Respiratory distress was often exacerbated by viral or bacterial infection persisting for more than a half year in about half of the patients examined. The IgA and IgM levels in the serum decreased considerably within 2 years after the onset of the disease and definite decreases in IgA levels may correlate well with the bacterial infection. PCBs found in sputa may have been present in association with lipid in type II cells of the lung (or with excretion from bronchial cells) and may have been phagocytosed in alveolar macrophages and may change their phagocytic function.

Ultrastructural study of pulmonary plasma cell granuloma--report of a case.

Electron microscopy of a tumour diagnosed as a pulmonary plasma cell granuloma showed that the tumour was composed of plasma cells, fibroblasts, histiocytes and other inflammatory cells. The plasma cells were mature, with abundant endoplasmic reticulum. Fibroblasts contained multiple lipid droplets and intracytoplasmic inclusions. The relationship between plasma cell granuloma and lesions believed to be related is discussed.

Immunological adjuvants IV. Relationship between adjuvant activity and antigenicity in mycobacterial adjuvant

Während sich bei Endotoxinen der Adjuvanseffekt proportional zur Antigenität verhält, ist diese Beziehung bei dem aus Tuberkelbazillen isolierten Wachs D nicht der Fall.

Adjuvant activity of ricin as measured by Jerne's plaque technique

Es wird gezeigt, dass Injektion von Rizinus-Extrakt die Plaque-Bildung im Jerne-Test fördert, was dafür spricht, dass die zytostatische Wirkung des Rizinus mit der Adjuvansfähigkeit gekoppelt ist.

Cholecystobronchial fistula with report of a case

SummaryA case of direct cholecystobronchial fistula was presented. It must be the second case of the disease reported in literatures and the first case diagnosed by means of endoscopic cholangiography. The present case was probably caused by gallbladder penetration with a gallstone after inflammatory adhesions occurring between the gallbladder and the diaphragm as well as the diaphragm and the lung. A radical operation was performed with a complete recovery. The etiology, diagnosis and treatment of the biliobronchial fistula were discussed.A case of direct cholecystobronchial fistula was presented. It must be the second case of the disease reported in literatures and the first case diagnosed by means of endoscopic cholangiography. The present case was probably caused by gallbladder penetration with a gallstone after inflammatory adhesions occurring between the gallbladder and the diaphragm as well as the diaphragm and the lung. A radical operation was performed with a complete recovery. The etiology, diagnosis and treatment of the biliobronchial fistula were discussed.