Li-Zhen Xu

Triterpenoid saponins from the stems of Clematis parviloba

Sixteen triterpenoid saponins (1–16) were isolated from the stems of Clematis parviloba, including a new compound, parvilobaside A (1), which was established as 23-O-acetyl-hederagenin-3-O-β-d-ribopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranoside on the basis of various spectroscopic techniques and chemical evidences. Among the isolated compounds, clematoside S (2) and α-hederin (4) showed moderate cytotoxic activities against four human tumor cell lines (HCT-8, Bel-7402, BGC-823, and A-2780) with IC50 values in the range of 1.44–6.86 μg/ml.

Inositol angelates from the whole herb of Inula cappa

A new inositol derivative, cis-1,2,3,5-trans-4,6-inositol-2,3,6-triangelate(1) along with the known l-inositol-1,2,3,5-tetra angelate(2), was isolated from the ethanolic extract of the whole plant Inula cappa and identified on the spectroscopic analysis.

Two new macrocyclic compounds from the stems of Clematis armandii

Phytochemical investigation of Clematis armandii (Ranunculaceae) has resulted in the isolation of two new macrocyclic compounds named clemoarmanosides A (1) and B (2), along with two known macrocyclic compounds berchemolide (3) and clemochinenoside B (4). The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical methods. In addition, several 13 C-NMR data of 4 were amended by 2D-NMR spectra analysis in this paper.

27-nor-triterpenoid glycosides from the barks of Zygophyllum fabago L.

From the bark of Zygophyllum fabago L., a new 27-nor-triterpenoid glycoside, 3-O-β-d-glucopyranosyl-pyrocincholate (1), together with five known compounds, 3-O-6-deoxy-β-d-glucopyranosyl-pyrocincholate (2), quinovic acid (3), 3-O-6-deoxy-β-d-glucopyranosyl-quinovic acid (4), 3-O-β-d-glucopyranosyl- quinovic acid (5) and 3-O-6-deoxy-β-d-glucopyranosyl-cincholic acid (6), were isolated and their structures elucidated on the basis of spectroscopic data. Compounds 1, 2 and 3 showed some anti-tumour activities by MTT assay.

A new sterol glycoside from Securidaca inappendiculata

From the roots of Securidaca inappendiculata, one new sterol glycoside securisteroside (1) has been isolated, along with two known sterols, spinasterol (2) and 3-O-β-D-glucopyranosyl-spinasterol (3). The new sterol was characterized by chemical and spectrometric methods, including EIMS, FABMS and one- and two-dimensional NMR experiments.

New Lignans from Kadsura coccinea and Their Nitric Oxide Inhibitory Activities

In vitro anti-allergic screening of medicinal herbal extracts revealed that the chloroform extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-y (IFN-y) activated murine macrophage like cell line, RAW264.7. Further fractionation of the chloroform extract led to the isolation of two new lignans kadsuralignans D (1) and E (2) with other two known dibenzocyclooctadiene lignans kadsulignan N (3) and neokadsuranin (4).

New antitumor triterpene saponin from Lysimachia capillipes

One new saponin, named capilliposide D (1), and a known saponin, candidoside (2), were isolated from the whole plants of Lysimachia capillipes. Their structures were determined by 1D and 2D NMR, MS techniques, and chemical methods.

One new triterpenoid saponin from Lysimachia davurica

One new saponin named davuricoside N (1) was isolated from the whole plants of Lysimachia davurica, the structure was determined by 1D and 2D NMR, ESI-MS techniques, and chemical methods.

Two new triterpene saponins from Lysimachia davurica.

Two new saponins, named davuricoside L (1) and davuricoside O (2), have been isolated from the whole plants of Lysimachia davurica. Their structures were determined by 1D and 2D NMR, FAB-MS techniques, and chemical methods.

A New Anthraquinone from Capparis himalayensis

A new anthraquinone, cappariquinone A (1), along with four known compounds, 2-hydroxy-1-methoxy-3-methylanthraquinone (2), vanillic acid (3), pyrogallic acid (4), and ergosterol (5), were isolated from the whole plant of Capparis himalayensis. The compounds 2, 4, and 5 are reported from this species for the first time.