Linh T. Tran

3D-Mesa “Bridge” Silicon Microdosimeter: Charge Collection Study and Application to RBE Studies in

Microdosimetry is an extremely useful technique, used for dosimetry in unknown mixed radiation fields typical of space and aviation, as well as in hadron therapy. A new silicon microdosimeter with 3D sensitive volumes has been proposed to overcome the shortcomings of the conventional Tissue Equivalent Proportional Counter. In this article, the charge collection characteristics of a new 3D mesa microdosimeter were investigated using the ANSTO heavy ion microprobe utilizing 5.5 MeV He2+ and 2 MeV H+ ions. Measurement of the microdosimetric characteristics allowed for the determination of the Relative Biological Effectiveness of the 12C heavy ion therapy beam at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan. Well-defined sensitive volumes of the 3D mesa microdosimeter have been observed and the microdosimetric RBE obtained showed good agreement with the TEPC. The new 3D mesa “bridge” microdosimeter is a step forward towards a microdosimeter with fully free-standing 3D sensitive volumes.

^{12}{\rm C}

Silicon microdosimetry is a promising technology for heavy ion therapy (HIT) quality assurance, because of its sub-mm spatial resolution and capability to determine radiation effects at a cellular level in a mixed radiation field. A drawback of silicon is not being tissue-equivalent, thus the need to convert the detector response obtained in silicon to tissue. This paper presents a method for converting silicon microdosimetric spectra to tissue for a therapeutic 12C beam, based on Monte Carlo simulations. The energy deposition spectra in a 10 μm sized silicon cylindrical sensitive volume (SV) were found to be equivalent to those measured in a tissue SV, with the same shape, but with dimensions scaled by a factor κ equal to 0.57 and 0.54 for muscle and water, respectively. A low energy correction factor was determined to account for the enhanced response in silicon at low energy depositions, produced by electrons. The concept of the mean path length [Formula: see text] to calculate the lineal energy was introduced as an alternative to the mean chord length [Formula: see text] because it was found that adopting Cauchys formula for the [Formula: see text] was not appropriate for the radiation field typical of HIT as it is very directional. [Formula: see text] can be determined based on the peak of the lineal energy distribution produced by the incident carbon beam. Furthermore it was demonstrated that the thickness of the SV along the direction of the incident 12C ion beam can be adopted as [Formula: see text]. The tissue equivalence conversion method and [Formula: see text] were adopted to determine the RBE10, calculated using a modified microdosimetric kinetic model, applied to the microdosimetric spectra resulting from the simulation study. Comparison of the RBE10 along the Bragg peak to experimental TEPC measurements at HIMAC, NIRS, showed good agreement. Such agreement demonstrates the validity of the developed tissue equivalence correction factors and of the determination of [Formula: see text].

Radiation Therapy

This paper presents a new version of the 3D mesa Bridge microdosimeter comprised of an array of 4248 silicon cells fabricated on 10 μm thick n-type silicon-on-insulator substrate. This microdosimeter has been designed to overcome limitations existing in previous generation silicon microdosimeters and it provides well-defined sensitive volumes and high spatial resolution. The charge collection characteristics of the new 3D mesa microdosimeter were investigated using the ANSTO heavy ion microprobe, utilizing 5.5 MeV He2 + ions. Measurement of microdosimetric quantities allowed for the determination of the relative biological effectiveness of 290 MeV/u and 350 MeV/u 12C heavy ion therapy beams at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan. The microdosimetric RBE obtained showed good agreement with the tissue-equivalent proportional counter. Utilizing the high spatial resolution of the SOI microdosimeter, the LET spectra for 70 MeV 12C+6 ions, like those present at the distal edge of 290 and 350 MeV/u beams, were obtained as the ions passed through thin layers of polyethylene film. This microdosimeter can provide useful information about the lineal energy transfer (LET) spectra downstream of the protective layers used for shielding of electronic devices for single event upset prediction.

Correction factors to convert microdosimetry measurements in silicon to tissue in 12C ion therapy

A 4th generation silicon microdosimeter has been designed by the Centre for Medical Radiation Physics (CMRP) at the University of Wollongong using three dimensional (3D) Sensitive Volumes (SVs). This new microdosimeter design has the advantage of well-defined 3D SVs as well as the elimination of lateral charge diffusion by removal of silicon laterally adjacent to the 3D SVs. The gaps between the sensitive volumes are to be backfilled with PolyMethyl MethAcrylate (PMMA) to produce a surrounding tissue equivalent medium. The advantage of this design avoids the generation of secondary particles from inactive silicon lateral to SVs. The response of the microdosimeter to the neutron field from 252Cf, Pu-Be sources and an avionic radiation environment were simulated using the Geant4 Monte Carlo toolkit for design optimisation. The simulated energy deposition in the SVs from the neutron fields and microdosimetric spectra is presented. The simulation study shows a significant reduction in silicon nuclear recoil contribution to the energy deposition for the novel microdosimeter design. The reduction of silicon recoil events from outside of the SVs will consequently reduce the uncertainty in the calculated dose equivalent. The simulations have demonstrated that a 3D silicon microdosimeter surrounded by PMMA can produce microdosimetric spectra similar to those of a tissue equivalent microdosimeter.

3D Silicon Microdosimetry and RBE Study Using

A study of charge collection in SINTEF 3D active edge silicon detectors was carried out at ANSTO using Ion Beam Induced Charge (IBIC) technique. An IBIC study has shown that several different geometries of 3D detectors have full depletion under low applied bias. The effect of fast neutron and gamma radiation on their charge collection efficiency was also investigated. A 3D active edge silicon detector technology has demonstrated extremely promising performance for application of the 3D Sensitive Volumes (SVs) fabrication methods to SOI microdosimetry.

^{12}{\rm C}

Purpose: This work aims to characterize a proton pencil beam scanning (PBS) and passive double scattering (DS) systems as well as to measure parameters relevant to the relative biological effectiveness (RBE) of the beam using a silicon on insulator (SOI) microdosimeter with well‐defined 3D sensitive volumes (SV). The dose equivalent downstream and laterally outside of a clinical PBS treatment field was assessed and compared to that of a DS beam. Methods: A novel silicon microdosimeter with well‐defined 3D SVs was used in this study. It was connected to low noise electronics, allowing for detection of lineal energies as low as 0.15 keV/μm. The microdosimeter was placed at various depths in a water phantom along the central axis of the proton beam, and at the distal part of the spread‐out Bragg peak (SOBP) in 0.5 mm increments. The RBE values of the pristine Bragg peak (BP) and SOBP were derived using the measured microdosimetric lineal energy spectra as inputs to the modified microdosimetric kinetic model (MKM). Geant4 simulations were performed in order to verify the calculated depth‐dose distribution from the treatment planning system (TPS) and to compare the simulated dose‐mean lineal energy to the experimental results. Results: For a 131 MeV PBS spot (124.6 mm R90 range in water), the measured dose‐mean lineal energy Symbol increased from 2 keV/μm at the entrance to 8 keV/μm in the BP, with a maximum value of 10 keV/μm at the distal edge. The derived RBE distribution for the PBS beam slowly increased from 0.97 ± 0.14 at the entrance to 1.04 ± 0.09 proximal to the BP, then to 1.1 ± 0.08 in the BP, and steeply rose to 1.57 ± 0.19 at the distal part of the BP. The RBE distribution for the DS SOBP beam was approximately 0.96 ± 0.16 to 1.01 ± 0.16 at shallow depths, and 1.01 ± 0.16 to 1.28 ± 0.17 within the SOBP. The RBE significantly increased from 1.29 ± 0.17 to 1.43 ± 0.18 at the distal edge of the SOBP. Symbol. No Caption available. Conclusions: The SOI microdosimeter with its well‐defined 3D SV has applicability in characterizing proton radiation fields and can measure relevant physical parameters to model the RBE with submillimeter spatial resolution. It has been shown that for a physical dose of 1.82 Gy at the BP, the derived RBE based on the MKM model increased from 1.14 to 1.6 in the BP and its distal part. Good agreement was observed between the experimental and simulation results, confirming the potential application of SOI microdosimeter with 3D SV for quality assurance in proton therapy.

Ion of Different Energies

An ultra-thin 3-D detector (U3DTHIN) with a 10- μm-thick active region has been proposed to apply for microdosimetry in heavy ion therapy where the ion beam incidence is normal to the detector. The advantage of the detector is that the detector substrate below the silicon-on-insulator layer has been etched away. Extremely small columnar 3-D electrodes allow the detector to be fully depleted at very low biases with a minimum dead region due to their size. In this paper, a charge collection study of the U3DTHIN detector carried out using an ion beam-induced charge collection (IBICC) technique is presented. The IBICC study utilized a microbeam of 5.5 MeV He2 + and 20 MeV 12C ions focused to approximately 1- μm diameter. Full charge collection was observed from a bias as low as -10 V. A comparison of the detector response when irradiated from the front and rear side is also presented.

A novel silicon microdosimeter using 3D sensitive volumes: modeling the response in neutron fields typical of aviation

Purpose: Microdosimetry is a vital tool for assessing the microscopic patterns of energy deposition by radiation, which ultimately govern biological effect. Solid‐state, silicon‐on‐insulator microdosimeters offer an approach for making microdosimetric measurements with high spatial resolution (on the order of tens of micrometers). These high‐resolution, solid‐state microdosimeters may therefore play a useful role in characterizing proton radiotherapy fields, particularly for making highly resolved measurements within the Bragg peak region. In this work, we obtain microdosimetric measurements with a solid‐state microdosimeter (MicroPlus probe) in a clinical, spot‐scanning proton beam of small spot size. Methods: The MicroPlus probe had a 3D single sensitive volume on top of silicon oxide. The sensitive volume had an active cross‐sectional area of 250 μm × 10 μm and thickness of 10 μm. The proton facility was a synchrotron‐based, spot‐scanning system with small spot size (σ ≈ 2 mm). We performed measurements with the clinical beam current (≈1 nA) and had no detected pulse pile‐up. Measurements were made in a water‐equivalent phantom in water‐equivalent depth (WED) increments of 0.25 mm or 1.0 mm along pristine Bragg peaks of energies 71.3 MeV and 159.9 MeV, respectively. For each depth, we measured lineal energy distributions and then calculated the dose‐weighted mean lineal energy, Symbol. The measurements were repeated for two field sizes: 4 × 4 cm2 and 20 × 20 cm2. Symbol. No Caption available. Results: For both 71.3 MeV and 159.9 MeV and for both field sizes, Symbol increased with depth toward the distal edge of the Bragg peak, a result consistent with Monte Carlo calculations and measurements performed elsewhere. For the 71.3 MeV, 4 × 4 cm2 beam (range at 80% distal falloff, R80 = 3.99 cm), we measured Symbol keV/μm at WED = 2 cm, and Symbol keV/μm at WED = 3.95 cm. For the 71.3 MeV, 20 × 20 cm2 beam, we measured Symbol keV/μm at WED = 2.6 cm, and Symbol keV/μm at WED = 3 cm. For the 159.9 MeV, 4 × 4 cm2 beam (R80 = 17.7 cm), Symbol keV/μm at WED = 5 cm, and Symbol keV/μm at WED = 17.6 cm. For the 159.9 MeV, 20 × 20 cm2 beam, Symbol keV/μm at WED = 5 cm, and Symbol keV/μm at WED = 17.6 cm. Symbol. No Caption available. Symbol. No Caption available. Symbol. No Caption available. Symbol. No Caption available. Symbol. No Caption available. Symbol. No Caption available. Symbol. No Caption available. Symbol. No Caption available. Symbol. No Caption available. Conclusions: We performed microdosimetric measurements with a novel solid‐state, silicon‐on‐insulator microdosimeter in a clinical spot‐scanning proton beam of small spot size and unmodified beam current. For all of the proton field sizes and energies considered, the measurements of Symbol were in agreement with expected trends. Furthermore, we obtained measurements with a spatial resolution of 10 μm in the beam direction. This spatial resolution greatly exceeded that possible with a conventional gaseous tissue‐equivalent proportional counter and allowed us to perform a high‐resolution investigation within the Bragg peak region. The MicroPlus probe is therefore suitable for applications in proton radiotherapy. Symbol. No Caption available.

3D Radiation Detectors: Charge Collection Characterisation and Applicability of Technology for Microdosimetry

An n-SOI microdosimeter which has been proposed as a device for predicting the occurrence of single event effects in semiconductor electronics in the high-energy, mixed heavy ion space radiation environment has been investigated to better understand the charge collection geometry and charge collection mechanisms. Ion beam induced charge collection studies using 20 MeV 12C ions, 5.5 MeV 4He ions, and 2 MeV H ions were carried out, and the effects of different bias conditions, angles of ion incidence, and coincidence analysis were observed to understand the sensitive volume geometry. The energy response of the n-SOI microdosimeter has been observed to exhibit an over-response of 56%, 113%, and 23% for the above ions compared to expected energy depositions calculated using SRIM 2008. No relationship between particle LET AU: Please provide spelling for “LET” and the enhance energy response was apparent. A comparison of experimentally measured and simulated spectra suggest a cylindrical charge collection geometry despite the physical rectangular parallelepiped geometry of the p-i-n diode. This was supported by observing the response of the microdosimeter to ions at oblique ion incidence. A simplified model of diffusion charge collection found that diffusion charge collection contributes to the low-energy tail observed in experimental spectra, but does not account for the observed enhanced energy response. This supports the current theory that the enhanced energy response is a result of a displacement current produced when charge carriers in the substrate induce charge in the SOI layer due to the parasitic capacitance of the buried SiO2 insulating layer.

Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

Heavy-particle therapy such as carbon ion therapy is currently very popular because of its superior conformality in terms of dose distribution and higher Relative Biological Effectiveness (RBE). However, carbon ion beams produce a complex mixed radiation field, which needs to be fully characterised. In this study, the fragmentation of a 290 MeV/u primary carbon ion beam was studied using the Geant4 Monte Carlo Toolkit. When the primary carbon ion beam interacts with water, secondary light charged particles (H, He, Li, Be, B) and fast neutrons are produced, contributing to the dose, especially after the distal edge of the Bragg peak.