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Current Opinion in Endocrinology, Diabetes and Obesity | 2008

Diabetes mellitus and inflammatory periodontal diseases

Brian L. Mealey; Louis F. Rose

PURPOSE OF REVIEW Periodontal diseases are inflammatory conditions that were once thought to have manifestations localized to the oral cavity alone, and were therefore considered the concern of only dentists and other oral health professionals. Emerging evidence has changed this view and now suggests that periodontal diseases may play a role in numerous conditions that impact systemic well being, including diabetes mellitus. This review examines the relationships that exist between periodontal diseases and diabetes mellitus, with a focus on potential common pathophysiologic pathways including those associated with inflammation, altered host responses, and insulin resistance. RECENT FINDINGS Periodontal inflammation is associated with an elevated systemic inflammatory state and an increased risk of major cardiovascular events such as myocardial infarction and stroke, adverse pregnancy outcomes such as preeclampsia, low birth weight and preterm birth, and altered glycemic control in people with diabetes. Intervention trials suggest that periodontal therapy, which decreases the intraoral bacterial bioburden and reduces periodontal inflammation, can have a significant impact on systemic inflammatory status. Evidence suggests that periodontal therapy is associated with improved glycemic control in many patients with both diabetes and periodontal diseases. SUMMARY Recognition of the bilateral relationships between oral and systemic health will challenge physicians and dentists to work together closely in the future when managing patients with diabetes and periodontal disease.Purpose of reviewPeriodontal diseases are inflammatory conditions that were once thought to have manifestations localized to the oral cavity alone, and were therefore considered the concern of only dentists and other oral health professionals. Emerging evidence has changed this view and now suggests that periodontal diseases may play a role in numerous conditions that impact systemic well being, including diabetes mellitus. This review examines the relationships that exist between periodontal diseases and diabetes mellitus, with a focus on potential common pathophysiologic pathways including those associated with inflammation, altered host responses, and insulin resistance. Recent findingsPeriodontal inflammation is associated with an elevated systemic inflammatory state and an increased risk of major cardiovascular events such as myocardial infarction and stroke, adverse pregnancy outcomes such as preeclampsia, low birth weight and preterm birth, and altered glycemic control in people with diabetes. Intervention trials suggest that periodontal therapy, which decreases the intraoral bacterial bioburden and reduces periodontal inflammation, can have a significant impact on systemic inflammatory status. Evidence suggests that periodontal therapy is associated with improved glycemic control in many patients with both diabetes and periodontal diseases. SummaryRecognition of the bilateral relationships between oral and systemic health will challenge physicians and dentists to work together closely in the future when managing patients with diabetes and periodontal disease.


Annals of Emergency Medicine | 1980

Interdisciplinary training: Hospital dental general practice/emergency medicine

James T. Amsterdam; David K. Wagner; Louis F. Rose

The interaction between the residency training program in hospital dental general practice and emergency medicine at The Medical College of Pennsylvania is discussed. The contribution by the emergency medicine resident to the training of the dental resident and the role of the dental resident in the education of the emergency medicine resident are described in detail. Methods for enhancing this unique relationship between two departments are presented.


Journal of Esthetic and Restorative Dentistry | 2015

Advanced Esthetic Management of Dental Implants: Surgical and Restorative Considerations to Improve Outcomes

Barry P. Levin; Sergio Rubinstein; Louis F. Rose

OBJECTIVE Successful dental implant therapy in the maxillary anterior dentition requires meticulous attention to surgical and prosthodontic measures. CLINICAL CONSIDERATIONS Proper diagnosis, extraction technique, implant selection, and placement significantly impact outcomes. Respect of hard and soft tissue physiology following tooth loss and implant placement requires specific steps be taken. Management tissue contours properly, via regenerative therapy, results in successful framing of the restoration. Provisionalization and definitive restorative therapy also impacts the level of esthetic success. The contours of the temporary abutment and crown develop soft tissue contours for the final restoration. Overcontouring can lead to soft tissue recession and mucosal asymmetry. Design of the definitive crown(s) is crucial for long-term maintenance of esthetically acceptable results. CONCLUSION Visualizing the outcome of treatment prior to its inception, following specific surgical and restorative guidelines, increases the likelihood of success. CLINICAL SIGNIFICANCE This article demonstrates the importance of proper surgical and prosthetic principles in achieving esthetic implant results.Objective Successful dental implant therapy in the maxillary anterior dentition requires meticulous attention to surgical and prosthodontic measures. Clinical Considerations Proper diagnosis, extraction technique, implant selection, and placement significantly impact outcomes. Respect of hard and soft tissue physiology following tooth loss and implant placement requires specific steps be taken. Management tissue contours properly, via regenerative therapy, results in successful framing of the restoration. Provisionalization and definitive restorative therapy also impacts the level of esthetic success. The contours of the temporary abutment and crown develop soft tissue contours for the final restoration. Overcontouring can lead to soft tissue recession and mucosal asymmetry. Design of the definitive crown(s) is crucial for long-term maintenance of esthetically acceptable results. Conclusion Visualizing the outcome of treatment prior to its inception, following specific surgical and restorative guidelines, increases the likelihood of success. Clinical Significance This article demonstrates the importance of proper surgical and prosthetic principles in achieving esthetic implant results.


Clinical Implant Dentistry and Related Research | 2000

A Prospective Multicenter Clinical Trial Comparing One‐ and Two‐Stage Titanium Screw‐Shaped Fixtures with One‐Stage Plasma‐Sprayed Solid‐Screw Fixtures

William Becker; Burton E. Becker; Andrea Ricci; Oded Bahat; Edwin S. Rosenberg; Louis F. Rose; Mark Handelsman; Hilton Israelson


Journal of the American Dental Association | 2002

Oral care for patients with cardiovascular disease and stroke.

Louis F. Rose; Brian Mealey; Laura Minsk; D. Walter Cohen


Compendium of continuing education in dentistry | 2008

Diabetes mellitus and inflammatory periodontal diseases.

Brian L. Mealey; Louis F. Rose


Journal of Periodontology | 1976

A Quantitative Measurement of Bacteremia and Its Relationship to Plaque Control

Harvey A. Wank; Matthew E. Levison; Louis F. Rose; D. Walter Cohen


Journal of Periodontology | 1976

Vitamin E and Periodontal Disease

Edwin Walter Slade; Doris Bartuska; Louis F. Rose; D. Walter Cohen


Compendium of continuing education in dentistry | 2000

The periodontal-medical risk relationship.

Cohen W; Louis F. Rose; Laura Minsk


Journal of the American Dental Association | 1975

Common medical emergencies: a dilemma in dental education

Barry H. Hendler; Louis F. Rose

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Brian L. Mealey

University of Texas Health Science Center at San Antonio

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D. Walter Cohen

University of Pennsylvania

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Laura Minsk

University of Pennsylvania

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Jeffrey Ganeles

Nova Southeastern University

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Alan L. Rosenfeld

University of Illinois at Chicago

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Barry H. Hendler

University of Pennsylvania

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Barry P. Levin

University of Pennsylvania

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Brian Mealey

University of Pennsylvania

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Burton E. Becker

University of Southern California

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